Abstract：
:Strictly lytic phages have been consensually preferred for phage therapy purposes. In contrast, temperate phages have been avoided due to an inherent capacity to mediate transfer of genes between bacteria by specialized transduction - an event that may increase bacterial virulence, for example, by promoting antibiotic resistance. Now, advances in sequencing technologies and synthetic biology are providing new opportunities to explore the use of temperate phages for therapy against bacterial infections. By doing so we can considerably expand our armamentarium against the escalating threat of antibiotic-resistant bacteria.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Monteiro R,Pires DP,Costa AR,Azeredo Jdoi
10.1016/j.tim.2018.10.008subject
Has Abstractpub_date
2019-04-01 00:00:00pages
368-378issue
4eissn
0966-842Xissn
1878-4380pii
S0966-842X(18)30231-2journal_volume
27pub_type
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