Abstract：
:Nguyen et al. used transposon sequencing analysis and competitive colonization assays to describe how aspartate/malate can trigger initial Salmonella Typhimurium gut-lumen colonization in mice, providing insight into the significance of certain key metabolites beyond the realm of Salmonella life. Metabolite-driven diagnostic and anti-infective strategies for preventing salmonellosis could rapidly emerge from this work.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Jepsen S,Jiang Sdoi
10.1016/j.tim.2020.06.007subject
Has Abstractpub_date
2020-09-01 00:00:00pages
701-703issue
9eissn
0966-842Xissn
1878-4380pii
S0966-842X(20)30186-4journal_volume
28pub_type
评论,杂志文章abstract：:Microbiology has unraveled rich evidence of ongoing reticulate evolutionary processes and complex interactions both within and between cells. These phenomena feature real biological networks, which can logically be analyzed using network-based tools. It is thus not surprising that network sciences, a field independent...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2019.11.006
更新日期：2020-04-01 00:00:00
abstract：:Two-component systems are characterized by phosphotransfer reactions involving histidine and aspartate residues in highly conserved signalling domains. Although the basic principles of signal transduction by these systems have been elucidated, several important aspects, such as their integration into more complex cell...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/s0966-842x(99)01458-4
更新日期：1999-03-01 00:00:00
abstract：:Intestinal epithelial cells secrete a spectrum of chemoattractant and proinflammatory cytokines after invasion by bacteria. We suggest the novel concept that epithelial cells not only act as a mechanical barrier to invasive bacteria, but that they also signal the presence of invasive pathogens to the mucosal immune an...
journal_title：Trends in microbiology
pub_type： 杂志文章
doi：10.1016/s0966-842x(00)88894-0
更新日期：1995-03-01 00:00:00
abstract：:DNA vaccines can induce potent humoral and cellular immune responses without any additional adjuvant. Recent studies indicate that unmethylated CpG dinucleotides within DNA vaccines are immune stimulatory and exert an essential endogenous adjuvant activity. These CpG motifs can be added deliberately to DNA or conventi...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/S0966-842X(97)01145-1
更新日期：1998-01-01 00:00:00
abstract：:In bacteria, Ca(2+) is implicated in a wide variety of cellular processes, including the cell cycle and cell division. Dedicated influx and efflux systems tightly control the low cytoplasmic Ca(2+) levels in prokaryotes. Additionally, the growing number of proteins containing various Ca(2+)-binding motifs supports the...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/s0966-842x(01)02284-3
更新日期：2002-02-01 00:00:00
abstract：:The global emergence of multidrug resistant Acinetobacter baumannii has reduced the number of clinically available antibiotics that retain activity against this pathogen. For this reason, the development of novel prevention and treatment strategies for infections caused by A. baumannii is necessary. Several studies ha...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2012.12.002
更新日期：2013-03-01 00:00:00
abstract：:Quorum sensing is a process of bacterial cell-cell communication that uses small diffusible molecules to coordinate diverse behaviors in response to population density. The only quorum-sensing system shared by Gram-positive and Gram-negative bacteria involves the production of autoinducer-2 (AI-2). The AI-2 synthase L...
journal_title：Trends in microbiology
pub_type： 杂志文章
doi：10.1016/j.tim.2006.01.003
更新日期：2006-03-01 00:00:00
abstract：:To enhance infection, enveloped viruses exploit adhesion molecules expressed on the surface of host cells. Specifically, phosphatidylserine (PS) receptors - including members of the human T cell immunoglobulin and mucin domain (TIM)-family - have gained attention for their ability to mediate the entry of many envelope...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2019.10.004
更新日期：2020-03-01 00:00:00
abstract：:Genome analyses of double strand DNA tailed bacteriophages argue that they evolve by recombinational reassortment of genes and by the acquisition of novel genes as simple genetic elements termed morons. These processes suggest a model for early virus evolution, wherein viruses can be regarded less as having derived fr...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/s0966-842x(00)01863-1
更新日期：2000-11-01 00:00:00
abstract：:Corynebacterium glutamicum, a Gram-positive soil bacterium, is used for the production of l-glutamate and l-lysine, both of which are derived from intermediates of the tricarboxylic acid (TCA) cycle. Recent studies have revealed that this amphibolic pathway is subject to complex regulation not only at the transcriptio...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2007.08.004
更新日期：2007-09-01 00:00:00
abstract：:Progress in understanding the evolution of infectious diseases has inspired proposals to manage the evolution of pathogen (including parasite) virulence. A common view is that social interventions that lower pathogen transmission will indirectly select lower virulence because of a trade-off between transmission and vi...
journal_title：Trends in microbiology
pub_type： 杂志文章
doi：10.1016/s0966-842x(02)00003-3
更新日期：2003-01-01 00:00:00
abstract：:Bacteria have evolved complex regulatory networks to control the activity of transcription and translation, and thus the growth rate, over a range of environmental conditions. Reengineering RNA polymerase and ribosomes allows modifying naturally evolved regulatory networks and thereby profoundly reorganizing the manne...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2016.12.009
更新日期：2017-06-01 00:00:00
abstract：:The interferon-inducible, transmembrane protein BST-2 (CD317, tetherin) directly holds fully formed enveloped virus particles to the cells that produce them, inhibiting their spread. BST-2 inhibits members of the retrovirus, filovirus, arenavirus and herpesvirus families. These viruses encode a variety of proteins to ...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2010.06.010
更新日期：2010-09-01 00:00:00
abstract：:Retroviruses, like other RNA viruses, mutate at very high rates (0.05-1 mutations per genome per replication cycle) and exist as complex genetically heterogeneous populations ('quasispecies') that are ever changing. De novo mutations are generated by inherently error-prone steps in the retroviral life cycle that intro...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/0966-842x(96)81500-9
更新日期：1996-01-01 00:00:00
abstract：:Most membrane-anchored histidine kinases (HKs) of bacterial two-component systems (2CSs) contain an extracellular input domain that is thought to be responsible for sensing an environmental cue. By contrast, intramembrane-sensing HKs (IM-HKs) lack a sensory domain and cannot perceive their stimuli directly. Instead, a...
journal_title：Trends in microbiology
pub_type： 杂志文章
doi：10.1016/j.tim.2014.05.006
更新日期：2014-10-01 00:00:00
abstract：:Although biologists have long recognized the importance of studying evolution to understand the organization of living organisms, only with the development of genomics have evolutionary studies become part of their routine toolkit. Placing genomes into an evolutionary framework has proved useful for understanding the ...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2007.01.007
更新日期：2007-03-01 00:00:00
abstract：:The Third International Symposium on Advancing Science and Elimination of the Use of Laboratory Animals for Development and Control of Vaccines and Hormones, organized by the National Institute of Public Health and the Environment (RIVM, The Netherlands) under the auspices of the International Association for Biologic...
journal_title：Trends in microbiology
pub_type：
doi：10.1016/s0966-842x(01)02295-8
更新日期：2002-02-01 00:00:00
abstract：:During the past few decades, increasing attention has focused on pathogenic fungi both as fascinating research subjects and as the agents of serious illness in diverse patient populations. In particular, opportunistic fungi such as Cryptococcus neoformans command notice as the ranks of their immunocompromised victims ...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/s0966-842x(00)01890-4
更新日期：2000-12-01 00:00:00
abstract：:Hepatitis C virus populations in infected individuals consist of quasispecies with diverse mutations. These quasispecies have different biological properties, and the analysis of these variants has led to new interpretations of viral persistence, carcinogenesis and resistance to interferon therapy. ...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/s0966-842x(00)89000-9
更新日期：1995-11-01 00:00:00
abstract：:Several times in this century, new and sometimes devastating diseases of cereal crops, caused by fungi in the genus Cochliobolus, have suddenly appeared. In many fungal diseases of plants the factors required for pathogenicity are unknown; in contrast, the key elements in each of several Cochliobolus diseases are know...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/0966-842x(93)90019-n
更新日期：1993-04-01 00:00:00
abstract：:Diverse enveloped viruses enter host cells by fusing their envelopes with cell membranes. The mechanisms of merger of lipid bilayers of two membranes mediated by influenza hemagglutinin and other viral fusion proteins apparently involve local lipidic connections that evolve into a bilayer septum in which a pore forms ...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/S0966-842X(97)01107-4
更新日期：1997-09-01 00:00:00
abstract：:Antifungal drug discovery is starting to benefit from the enormous advances in the genomics field, which have occurred in the past decade. As traditional drug screening on existing targets is not delivering the long-awaited potent antifungals, efforts to use novel genetics and genomics-based strategies to aid in the d...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2003.08.008
更新日期：2003-10-01 00:00:00
abstract：:Some viruses have the ability to modulate the development of autoimmune diseases. Virus infections have long been associated with the exacerbation of autoimmune disease, however, there is also evidence that viruses can actually protect against autoimmune disease. Several experimental models have been developed to inve...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/s0966-842x(01)02097-2
更新日期：2001-08-01 00:00:00
abstract：:Across a range of pathogens, resistance to chemotherapy is a growing problem in both public health and animal health. Despite the ubiquity of coinfection, and its potential effects on within-host biology, the role played by coinfecting pathogens on the evolution of resistance and efficacy of antimicrobial chemotherapy...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2015.05.002
更新日期：2015-09-01 00:00:00
abstract：:Seasonal influenza is controlled through vaccination campaigns. Evolution of influenza virus antigens means that vaccines must be updated to match novel strains, and vaccine effectiveness depends on the ability of scientists to predict nearly a year in advance which influenza variants will dominate in upcoming seasons...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2017.09.004
更新日期：2018-02-01 00:00:00
abstract：:The tricorn protease is an archaeal protease that forms massive proteasome-like capsids with a hollow chamber. beta-Propeller and PDZ domains are thought to play a role in substrate selection. By analysis of predicted proteins from novel bacterial genome sequences, we have identified four new bacterial tricorn-like pr...
journal_title：Trends in microbiology
pub_type： 杂志文章
doi：10.1016/s0966-842x(01)02199-0
更新日期：2001-11-01 00:00:00
abstract：:The spectacular ability of Epstein-Barr virus (EBV) to immortalize and morphologically transform human B cells in vitro to lymphoblastoid cell lines (LCLs) is central to most molecular models of viral oncogenesis. However, binding of transcription factor and oncoprotein c-Myc to the major locus control region (LCR) of...
journal_title：Trends in microbiology
pub_type： 杂志文章
doi：10.1016/j.tim.2004.09.006
更新日期：2004-11-01 00:00:00
abstract：:The following pair of articles, the first by Gil Segal and Howard Shuman, and the second by James Kirby and Ralph Isberg (Trends Microbiol. 6, 256-258), explore the genetics and function of the icm/dot genes of Legionella pneumophila. This gene family is implicated in several aspects of virulence and appears to consti...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/s0966-842x(98)01308-0
更新日期：1998-07-01 00:00:00
abstract：:The airways of patients afflicted with cystic fibrosis (CF) are colonized by many pathogens, the most predominant of which is the Gram-negative bacterium Pseudomonas aeruginosa. In the thick CF airway mucus, P. aeruginosa forms antibiotic- and phagocyte-resistant structures known as biofilms, which enable the survival...
journal_title：Trends in microbiology
pub_type： 杂志文章,评审
doi：10.1016/j.tim.2008.12.003
更新日期：2009-03-01 00:00:00
abstract：:An individual's microbiome is likely to be an important contributor to certain health disparity diseases and conditions. We present a framework to study the role of the microbiome and the multiple factors that are likely to influence differences in disease predisposition, onset, and progression at the individual and p...
journal_title：Trends in microbiology
pub_type： 杂志文章
doi：10.1016/j.tim.2016.08.001
更新日期：2016-11-01 00:00:00
