Microbial endocrinology: how stress influences susceptibility to infection.


:A holistic approach to understanding the mechanisms by which stress influences the pathogenesis of infectious disease has resulted in the development of the field of microbial endocrinology. This transdisciplinary field represents the intersection of microbiology with mammalian endocrinology and neurophysiology, and is based on the tenet that microorganisms have evolved systems for using neurohormones, which are widely distributed throughout nature, as environmental cues to initiate growth and pathogenic processes. This review reveals that responsiveness to human stress hormones is widespread in the microbial world and documents recent advances in microbial endocrinology.


Trends Microbiol


Trends in microbiology


Freestone PP,Sandrini SM,Haigh RD,Lyte M




Has Abstract


2008-02-01 00:00:00














  • Quantifying Current Events Identifies a Novel Endurance Regulator.

    abstract::In nongrowing microbes, proteome turnover is reduced and identification of newly synthesized, low-abundance proteins is challenging. Babin and colleagues recently utilized bio-orthogonal noncanonical amino acid tagging (BONCAT) to identify actively synthesized proteins in nongrowing Pseudomonas aeruginosa, discovering...

    journal_title:Trends in microbiology

    pub_type: 杂志文章


    authors: Henry TC,Brynildsen MP

    更新日期:2016-05-01 00:00:00

  • Challenging the trade-off model for the evolution of virulence: is virulence management feasible?

    abstract::Progress in understanding the evolution of infectious diseases has inspired proposals to manage the evolution of pathogen (including parasite) virulence. A common view is that social interventions that lower pathogen transmission will indirectly select lower virulence because of a trade-off between transmission and vi...

    journal_title:Trends in microbiology

    pub_type: 杂志文章


    authors: Ebert D,Bull JJ

    更新日期:2003-01-01 00:00:00

  • Life in grasses: diazotrophic endophytes.

    abstract::N2-fixing bacteria such as Azoarcus spp., Herbaspirillum spp, and Acetobacter diazotrophicus can infect the interior of gramineous plants without causing symptoms of plant disease but do not survive in soil. Like phytopathogens, they can penetrate into central tissues and spread systemically. There is no evidence for ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Reinhold-Hurek B,Hurek T

    更新日期:1998-04-01 00:00:00

  • Mechanisms of retroviral mutation.

    abstract::Retroviruses, like other RNA viruses, mutate at very high rates (0.05-1 mutations per genome per replication cycle) and exist as complex genetically heterogeneous populations ('quasispecies') that are ever changing. De novo mutations are generated by inherently error-prone steps in the retroviral life cycle that intro...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Preston BD,Dougherty JP

    更新日期:1996-01-01 00:00:00

  • Influenza H3N2 Vaccines: Recent Challenges.

    abstract::H3N2-subtype influenza A viruses are major causes of seasonal influenza epidemics. Emerging H3N2 variants require the annual adjustment of the vaccine strain. Recently, studies addressing the reduced effectiveness of current H3N2 vaccines have identified production-related substitutions in the viral hemagglutinin anti...

    journal_title:Trends in microbiology

    pub_type: 评论,杂志文章


    authors: Mostafa A,Pleschka S

    更新日期:2018-02-01 00:00:00

  • The rumen microbial ecosystem--some recent developments.

    abstract::The rumen of sheep and cattle represents a mobile, self-sustaining fermentation system for plant material. Analysis of the rumen flora continues to provide fundamental knowledge of anaerobic microbiology and is now yielding microbial genes that have potential in biotechnology. Recent research has provided fascinating ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Flint HJ

    更新日期:1997-12-01 00:00:00

  • Health Disparities and the Microbiome.

    abstract::An individual's microbiome is likely to be an important contributor to certain health disparity diseases and conditions. We present a framework to study the role of the microbiome and the multiple factors that are likely to influence differences in disease predisposition, onset, and progression at the individual and p...

    journal_title:Trends in microbiology

    pub_type: 杂志文章


    authors: Findley K,Williams DR,Grice EA,Bonham VL

    更新日期:2016-11-01 00:00:00

  • Diversity and disease pathogenesis in Mycobacterium tuberculosis.

    abstract::The increasing availability of whole-genome sequence (WGS) data for Mycobacterium tuberculosis, the bacterium that causes tuberculosis (TB), suggests that circulating genotypes have been molded by three dominant evolutionary forces: long-term persistence within the human population, which requires a core programme of ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Warner DF,Koch A,Mizrahi V

    更新日期:2015-01-01 00:00:00

  • In Silico Vaccine Strain Prediction for Human Influenza Viruses.

    abstract::Vaccines preventing seasonal influenza infections save many lives every year; however, due to rapid viral evolution, they have to be updated frequently to remain effective. To identify appropriate vaccine strains, the World Health Organization (WHO) operates a global program that continually generates and interprets s...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Klingen TR,Reimering S,Guzmán CA,McHardy AC

    更新日期:2018-02-01 00:00:00

  • How do filovirus filaments bend without breaking?

    abstract::Viruses of the Mononegavirales have helical nucleocapsids containing a single-stranded negative-sense RNA genome complexed with the nucleoprotein and several other virus-encoded proteins. This RNA-protein complex acts as the template for replication and transcription during infection. Recent structural data has advanc...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Booth TF,Rabb MJ,Beniac DR

    更新日期:2013-11-01 00:00:00

  • Acquisition and storage of inorganic iron and hemin by the yersiniae.

    abstract::Pathogenic Yersinia express a complex array of iron-regulated functions and possess mechanisms for inorganic iron and hemin acquisition. These include a unique temperature-regulated hemin storage system, high-affinity transport processes for hemin and inorganic iron, and an iron-responsive regulatory system controllin...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Perry RD

    更新日期:1993-07-01 00:00:00

  • How rolling circle plasmids control their copy number.

    abstract::Rolling circle DNA replication is inherently continuous and unregulated. This 'go-for-broke' strategy works well for lytic phages but is suicidal for plasmids that must coexist with their host. Plasmids have consequently evolved elaborate copy number control systems that operate at the transcriptional, translational a...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Rasooly A,Rasooly RS

    更新日期:1997-11-01 00:00:00

  • The causes and consequences of genetic variation in dengue virus.

    abstract::Despite the fact that dengue is one of the most prevalent viral infections of humans, the mechanisms responsible for its pathogenesis remain uncertain. Evolutionary studies of dengue virus have revealed that its genetic diversity is increasing. This, coupled with evidence that viral strains could naturally differ in v...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Holmes EC,Burch SS

    更新日期:2000-02-01 00:00:00

  • Exploration into the spatial and temporal mechanisms of bacterial polarity.

    abstract::The recognition of bacterial asymmetry is not new: the first high-resolution microscopy studies revealed that bacteria come in a multitude of shapes and sometimes carry asymmetrically localized external structures such as flagella on the cell surface. Even so, the idea that bacteria could have an inherent overall pola...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Ebersbach G,Jacobs-Wagner C

    更新日期:2007-03-01 00:00:00

  • The Molecular Language of the Cnidarian-Dinoflagellate Symbiosis.

    abstract::The cnidarian-dinoflagellate symbiosis is of huge importance as it underpins the success of coral reefs, yet we know very little about how the host cnidarian and its dinoflagellate endosymbionts communicate with each other to form a functionally integrated unit. Here, we review the current knowledge of interpartner mo...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Rosset SL,Oakley CA,Ferrier-Pagès C,Suggett DJ,Weis VM,Davy SK

    更新日期:2020-09-23 00:00:00

  • Gates of Janus: cystic fibrosis and diarrhea.

    abstract::Heat-stable enterotoxin, produced by Escherichia coli, binds to particulate guanylate cyclase to increase cyclic GMP in intestinal cells. This in turn stimulates the cyclic-GMP- or cyclic-AMP-dependent protein kinase, activating the same chloride channel that is defective in cystic fibrosis. It is possible that the re...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Guggino SE

    更新日期:1994-03-01 00:00:00

  • Structural evolution of multisubunit RNA polymerases.

    abstract::Evolutionarily related multisubunit RNA polymerases (RNAPs) facilitate gene transcription throughout the three domains of life. During the past seven years an increasing number of bacterial and eukaryotic RNAP structures have been solved; however, the archaeal enzyme remained elusive. Two reports from the Murakami and...

    journal_title:Trends in microbiology

    pub_type: 评论,杂志文章


    authors: Werner F

    更新日期:2008-06-01 00:00:00

  • The molecular mechanism of transcription-coupled DNA repair.

    abstract::DNA damage that blocks the transcription of genes is prioritized for repair by transcription-coupled DNA repair pathways. RNA polymerases stalled at DNA lesions obstruct repair enzymes, but this situation is turned to the advantage of the cell by transcription-repair coupling factors that remove the stalled RNA polyme...

    journal_title:Trends in microbiology

    pub_type: 杂志文章


    authors: Savery NJ

    更新日期:2007-07-01 00:00:00

  • The role of microbiota in infectious disease.

    abstract::The intestine harbors an ecosystem composed of the intestinal mucosa and the commensal microbiota. The microbiota fosters development, aids digestion and protects host cells from pathogens - a function referred to as colonization resistance. Little is known about the molecular basis of colonization resistance and how ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Stecher B,Hardt WD

    更新日期:2008-03-01 00:00:00

  • Multifaceted Roles of TIM-Family Proteins in Virus-Host Interactions.

    abstract::To enhance infection, enveloped viruses exploit adhesion molecules expressed on the surface of host cells. Specifically, phosphatidylserine (PS) receptors - including members of the human T cell immunoglobulin and mucin domain (TIM)-family - have gained attention for their ability to mediate the entry of many envelope...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Evans JP,Liu SL

    更新日期:2020-03-01 00:00:00

  • Architectural plan of transcriptional regulation in Mycobacterium tuberculosis.

    abstract::Transcriptional regulation enables adaptation in bacteria. Typically, only a few transcriptional events are well understood, leaving many others unidentified. The recent genome-wide identification of transcription factor binding sites in Mycobacterium tuberculosis has changed this by deciphering a molecular road-map o...

    journal_title:Trends in microbiology

    pub_type: 评论,杂志文章


    authors: Baloni P,Chandra N

    更新日期:2015-03-01 00:00:00

  • Leeches and their microbiota: naturally simple symbiosis models.

    abstract::Strictly blood-feeding leeches and their limited microbiota provide natural and powerful model systems to examine symbiosis. Blood is devoid of essential nutrients and it is thought that symbiotic bacteria synthesize these for the host. In this review, three distinct leech-microbe associations are described: (i) the m...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Graf J,Kikuchi Y,Rio RV

    更新日期:2006-08-01 00:00:00

  • Capturing cellular machines by systematic screens of protein complexes.

    abstract::Two recent studies have provided the most complete screen for protein complexes in yeast to date, in which partners were identified for approximately half of the proteome. A comparison shows that these two datasets are complementary. In addition, one of the analyses points to a modular organization of the cellular pro...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Gagneur J,David L,Steinmetz LM

    更新日期:2006-08-01 00:00:00

  • Thiol-Disulfide Exchange in Gram-Positive Firmicutes.

    abstract::Extracytoplasmic thiol-disulfide oxidoreductases (TDORs) catalyze the oxidation, reduction, and isomerization of protein disulfide bonds. Although these processes have been characterized in Gram-negative bacteria, the majority of Gram-positive TDORs have only recently been discovered. Results from recent studies have ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Davey L,Halperin SA,Lee SF

    更新日期:2016-11-01 00:00:00

  • Evolution of Wolbachia pipientis transmission dynamics in insects.

    abstract::Wolbachia pipientis is an intracellular bacterial parasite of arthropods that enhances its transmission by manipulating host reproduction, most commonly by inducing cytoplasmic incompatibility. The discovery of isolates with modified cytoplasmic incompatibility phenotypes and others with novel virulence properties is ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: McGraw EA,O'Neill SL

    更新日期:1999-07-01 00:00:00

  • Positive Interactions in the Coral Macro and Microbiome.

    abstract::Researchers now recognize the importance of the coral microbiome, but they often overlook other species that live on corals and influence coral-microbe interactions. These 'interstitial associates' should be incorporated into the metaorganism concept for insights into how facilitations between associates, corals, and ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章


    authors: Ainsworth TD,Renzi JJ,Silliman BR

    更新日期:2020-08-01 00:00:00

  • Portrait of Candida Species Biofilm Regulatory Network Genes.

    abstract::Most cases of candidiasis have been attributed to Candida albicans, but Candida glabrata, Candida parapsilosis and Candida tropicalis, designated as non-C. albicans Candida (NCAC), have been identified as frequent human pathogens. Moreover, Candida biofilms are an escalating clinical problem associated with significan...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Araújo D,Henriques M,Silva S

    更新日期:2017-01-01 00:00:00

  • The basis of persistent bacterial infections.

    abstract::Selected bacterial pathogens, such as Helicobacter pylori and Mycobacterium tuberculosis, establish persistent infections in mammalian hosts despite activating inflammatory and antimicrobial responses. The strategies used to overcome host defense responses vary with the anatomical location of the infection but often r...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Rhen M,Eriksson S,Clements M,Bergström S,Normark SJ

    更新日期:2003-02-01 00:00:00

  • How does Staphylococcus aureus escape the bloodstream?

    abstract::Staphylococcus aureus is a major cause of bacteraemia, which frequently leads to infective endocarditis, osteomyelitis, septic arthritis and metastatic abscess formation. The development of these secondary infections is due to bacterial dissemination from the blood into surrounding tissues and is associated with signi...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审


    authors: Edwards AM,Massey RC

    更新日期:2011-04-01 00:00:00

  • On the horizon: a blood test for prions.

    abstract::A recent paper by Castilla et al. reported the detection of prions in the blood of scrapie-infected hamsters using a biochemical amplification method that is conceptually analogous to the polymerase chain reaction. This technological advance raises the possibility that prion diseases in humans and livestock could soon...

    journal_title:Trends in microbiology

    pub_type: 杂志文章


    authors: Supattapone S,Geoghegan JC,Rees JR

    更新日期:2006-04-01 00:00:00