Abstract：
:The bacterial type IV pilus (T4P) is a versatile molecular machine with a broad range of functions. Recent advances revealed that the molecular components and the biophysical properties of the machine are well conserved among phylogenetically distant bacterial species. However, its functions are diverse, and include adhesion, motility, and horizontal gene transfer. This review focusses on the role of T4P in surface motility and bacterial interactions. Different species have evolved distinct mechanisms for intracellular coordination of multiple pili and of pili with other motility machines, ranging from physical coordination to biochemical clocks. Coordinated behavior between multiple bacteria on a surface is achieved by active manipulation of surfaces and modulation of pilus-pilus interactions. An emerging picture is that the T4P actively senses and responds to environmental conditions.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Maier B,Wong GCLdoi
10.1016/j.tim.2015.09.002subject
Has Abstractpub_date
2015-12-01 00:00:00pages
775-788issue
12eissn
0966-842Xissn
1878-4380pii
S0966-842X(15)00204-8journal_volume
23pub_type
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