Abstract：
:Significant advances have been made in recent years in our understanding of how methicillin resistance is acquired by Staphylococcus aureus. Integration of a staphylococcal cassette chromosome mec (SCCmec) element into the chromosome converts drug-sensitive S. aureus into the notorious hospital pathogen methicilin-resistant S. aureus (MRSA), which is resistant to practically all beta-lactam antibiotics. SCCmec is a novel class of mobile genetic element that is composed of the mec gene complex encoding methicillin resistance and the ccr gene complex that encodes recombinases responsible for its mobility. These elements also carry various resistance genes for non-beta-lactam antibiotics. After acquiring an SCCmec element, MRSA undergoes several mutational events and evolves into the most difficult-to-treat pathogen in hospitals, against which all extant antibiotics including vancomycin are ineffective. Recent epidemiological data imply that MRSA has embarked on another evolutionary path as a community pathogen, as at least one novel SCCmec element seems to have been successful in converting S. aureus strains from the normal human flora into MRSA.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Hiramatsu K,Cui L,Kuroda M,Ito Tdoi
10.1016/s0966-842x(01)02175-8subject
Has Abstractpub_date
2001-10-01 00:00:00pages
486-93issue
10eissn
0966-842Xissn
1878-4380pii
S0966-842X(01)02175-8journal_volume
9pub_type
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