Abstract:
:Interbacterial communication can be mediated by soluble secreted factors and direct cell-cell contact. Recently, Aoki et al. identified a new contact-dependent communication pathway by which strains of uropathogenic Escherichia coli can inhibit the growth of other microbes within a mixed population. Two novel gene products--CdiA and CdiB, which seem to be members of a two-partner secretion family with homologs in many pathogens--mediate this contact-dependent inhibition (CDI). A third gene product, CdiI, provides immunity to CDI, as does expression of either P or S pili. The interplay between CDI and immunity factors could directly affect the course of an infection and modulate both the dispersion and the chronic persistence of bacterial pathogens within the host.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Slechta ES,Mulvey MAdoi
10.1016/j.tim.2005.12.003subject
Has Abstractpub_date
2006-02-01 00:00:00pages
58-60issue
2eissn
0966-842Xissn
1878-4380pii
S0966-842X(05)00334-3journal_volume
14pub_type
杂志文章abstract::Microbial pathogens possess a diversity of weapons that disrupt host homeostasis and immune defenses, thus resulting in the establishment of infection. The best-characterized system mediating bacterial protein delivery into target eukaryotic cells is the type III secretion system (T3SS) expressed by Gram-negative bact...
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abstract::Bacterial motility relies chiefly on the rotation of a molecular propeller, the flagellar filament, which is constructed from the protein flagellin. Here, flagellin sequence conservation and diversity is examined in the light of the recently determined flagellar filament structure. As expected, the surface-exposed dom...
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abstract::Bacteriophages are viruses of bacteria that are used for controlling bacterial food-borne pathogens and have been proposed for more extensive usage in infection control. Protists are now recognised to harbour viruses and virus-like particles. We propose that investigation of their prevalence in parasites be intensifie...
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journal_title:Trends in microbiology
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abstract::Hospitals worldwide are facing an increasing incidence of hard-to-treat infections. Limiting infections and providing patients with optimal drug regimens require timely strain identification as well as virulence and drug-resistance profiling. Additionally, prophylactic interventions based on the identification of envi...
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journal_title:Trends in microbiology
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journal_title:Trends in microbiology
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abstract::The recent observation of a surge in human monkeypox in the Democratic Republic of the Congo (DRC) prompts the question of whether cessation of smallpox vaccination is driving the phenomenon, and if so, why is re-emergence not universal throughout the historic geographic range of the virus? Research addressing the vir...
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journal_title:Trends in microbiology
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abstract::Cell-density-dependent gene expression is widespread in bacteria and is mediated by extracellular communication molecules. Gram-negative bacteria often use N-acyl homoserine lactones, whereas cell-cell signaling in Gram-positive bacteria is accomplished using post-translationally processed peptide pheromones. In many ...
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abstract::The genetic analysis of the large and complex herpesviruses has been a constant challenge to herpesvirologists. Elegant methods have been developed to produce mutants in infected cells that rely on the cellular recombination machinery. Bacterial artificial chromosomes (BACs), single copy F-factor-based plasmid vectors...
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