Abstract：
:Cell-density-dependent gene expression is widespread in bacteria and is mediated by extracellular communication molecules. Gram-negative bacteria often use N-acyl homoserine lactones, whereas cell-cell signaling in Gram-positive bacteria is accomplished using post-translationally processed peptide pheromones. In many Gram-positive bacteria, export of these peptides requires the activity of a dedicated ATP-binding cassette (ABC) transporter, which cleaves off a typical leader peptide termed the double-glycine leader sequence concomitant with translocation across the membrane. Inspection of bacterial genome sequences has revealed the presence of similar ABC transporters, as well as genes encoding peptides with double-glycine-type leader sequences in Gram-negative bacteria, and it is suggested that the postulated transported peptides could perform a signaling function.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Michiels J,Dirix G,Vanderleyden J,Xi Cdoi
10.1016/s0966-842x(01)01979-5subject
Has Abstractpub_date
2001-04-01 00:00:00pages
164-8issue
4eissn
0966-842Xissn
1878-4380pii
S0966-842X(01)01979-5journal_volume
9pub_type
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