Abstract：
:Hospitals worldwide are facing an increasing incidence of hard-to-treat infections. Limiting infections and providing patients with optimal drug regimens require timely strain identification as well as virulence and drug-resistance profiling. Additionally, prophylactic interventions based on the identification of environmental sources of recurrent infections (e.g., contaminated sinks) and reconstruction of transmission chains (i.e., who infected whom) could help to reduce the incidence of nosocomial infections. WGS could hold the key to solving these issues. However, uptake in the clinic has been slow. Some major scientific and logistical challenges need to be solved before WGS fulfils its potential in clinical microbial diagnostics. In this review we identify major bottlenecks that need to be resolved for WGS to routinely inform clinical intervention and discuss possible solutions.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Balloux F,Brønstad Brynildsrud O,van Dorp L,Shaw LP,Chen H,Harris KA,Wang H,Eldholm Vdoi
10.1016/j.tim.2018.08.004subject
Has Abstractpub_date
2018-12-01 00:00:00pages
1035-1048issue
12eissn
0966-842Xissn
1878-4380pii
S0966-842X(18)30176-8journal_volume
26pub_type
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