Restriction of retroviral replication by APOBEC3G/F and TRIM5alpha.

Abstract:

:Pathogenic viral infections have exerted selection pressure on their hosts to evolve cellular antiviral inhibitors referred to as restriction factors. Examples of such molecules are APOBEC3G, APOBEC3F and TRIM5alpha. APOBEC3G and APOBEC3F are cytidine deaminases that are able to strongly inhibit retroviral replication by at least two mechanisms. They are counteracted by the lentiviral Vif protein. TRIM5alpha binds to sensitive, incoming retroviruses via its C-terminal PRY/SPRY domain and rapidly recruits them to the proteasome before significant viral DNA synthesis can occur. Both of these proteins robustly block retroviral replication in a species-specific way. It remains an open but important question as to whether innate restriction factors such as these can be harnessed to inhibit HIV-1 replication in humans.

journal_name

Trends Microbiol

journal_title

Trends in microbiology

authors

Huthoff H,Towers GJ

doi

10.1016/j.tim.2008.08.013

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

612-9

issue

12

eissn

0966-842X

issn

1878-4380

pii

S0966-842X(08)00224-2

journal_volume

16

pub_type

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