Abstract:
:Pathogenic viral infections have exerted selection pressure on their hosts to evolve cellular antiviral inhibitors referred to as restriction factors. Examples of such molecules are APOBEC3G, APOBEC3F and TRIM5alpha. APOBEC3G and APOBEC3F are cytidine deaminases that are able to strongly inhibit retroviral replication by at least two mechanisms. They are counteracted by the lentiviral Vif protein. TRIM5alpha binds to sensitive, incoming retroviruses via its C-terminal PRY/SPRY domain and rapidly recruits them to the proteasome before significant viral DNA synthesis can occur. Both of these proteins robustly block retroviral replication in a species-specific way. It remains an open but important question as to whether innate restriction factors such as these can be harnessed to inhibit HIV-1 replication in humans.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Huthoff H,Towers GJdoi
10.1016/j.tim.2008.08.013subject
Has Abstractpub_date
2008-12-01 00:00:00pages
612-9issue
12eissn
0966-842Xissn
1878-4380pii
S0966-842X(08)00224-2journal_volume
16pub_type
杂志文章,评审abstract::As plastic debris in the environment continues to increase, an emerging concern is the potential for microplastic to act as vectors for pathogen transport. With aquaculture the fastest growing food sector, and microplastic contamination of shellfish increasingly demonstrated, understanding any risk of pathogen transpo...
journal_title:Trends in microbiology
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journal_title:Trends in microbiology
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abstract::New, post-genomic analyses are increasing the rate at which information about highly complex processes such as bacterial growth and development can be acquired. The recent use of DNA-microarray and proteomic analysis to study the differentiating bacterium Caulobacter crescentus has provided the first global view of th...
journal_title:Trends in microbiology
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journal_title:Trends in microbiology
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
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journal_title:Trends in microbiology
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doi:10.1016/j.tim.2007.09.001
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journal_title:Trends in microbiology
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journal_title:Trends in microbiology
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2006-12-01 00:00:00
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journal_title:Trends in microbiology
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更新日期:2016-02-01 00:00:00
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2012.09.003
更新日期:2012-12-01 00:00:00
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2007.04.005
更新日期:2007-06-01 00:00:00
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2004.11.010
更新日期:2005-01-01 00:00:00
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journal_title:Trends in microbiology
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doi:10.1016/j.tim.2020.02.009
更新日期:2020-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0966-842x(00)88894-0
更新日期:1995-03-01 00:00:00
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
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更新日期:1994-05-01 00:00:00
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
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journal_title:Trends in microbiology
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更新日期:2014-12-01 00:00:00
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journal_title:Trends in microbiology
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更新日期:2001-01-01 00:00:00
abstract::Ribosome research has undergone astonishing progress in recent years. Crystal structures have shed light on the functional properties of the translation machinery and revealed how the striking architecture of the ribosome is ingeniously designed as the framework for its unique capabilities: precise decoding, substrate...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2008.05.001
更新日期:2008-07-01 00:00:00