Restriction of retroviral replication by APOBEC3G/F and TRIM5alpha.

Abstract:

:Pathogenic viral infections have exerted selection pressure on their hosts to evolve cellular antiviral inhibitors referred to as restriction factors. Examples of such molecules are APOBEC3G, APOBEC3F and TRIM5alpha. APOBEC3G and APOBEC3F are cytidine deaminases that are able to strongly inhibit retroviral replication by at least two mechanisms. They are counteracted by the lentiviral Vif protein. TRIM5alpha binds to sensitive, incoming retroviruses via its C-terminal PRY/SPRY domain and rapidly recruits them to the proteasome before significant viral DNA synthesis can occur. Both of these proteins robustly block retroviral replication in a species-specific way. It remains an open but important question as to whether innate restriction factors such as these can be harnessed to inhibit HIV-1 replication in humans.

journal_name

Trends Microbiol

journal_title

Trends in microbiology

authors

Huthoff H,Towers GJ

doi

10.1016/j.tim.2008.08.013

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

612-9

issue

12

eissn

0966-842X

issn

1878-4380

pii

S0966-842X(08)00224-2

journal_volume

16

pub_type

杂志文章,评审
  • Oceanic Hitchhikers - Assessing Pathogen Risks from Marine Microplastic.

    abstract::As plastic debris in the environment continues to increase, an emerging concern is the potential for microplastic to act as vectors for pathogen transport. With aquaculture the fastest growing food sector, and microplastic contamination of shellfish increasingly demonstrated, understanding any risk of pathogen transpo...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2020.06.011

    authors: Bowley J,Baker-Austin C,Porter A,Hartnell R,Lewis C

    更新日期:2021-02-01 00:00:00

  • p53 and tumour viruses: catching the guardian off-guard.

    abstract::Oncogenic viruses have evolved direct and indirect mechanisms to overcome the tumour suppressor p53. Fortunately, tumour development is limited by the narrow cell tropisms of the viruses concerned and the host immune response. However, such viruses are helping to elucidate the p53 response pathway and may play a futur...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/S0966-842X(96)10083-4

    authors: Neil JC,Cameron ER,Baxter EW

    更新日期:1997-03-01 00:00:00

  • Global analysis of a bacterial cell cycle: tracking down necessary functions and their regulators.

    abstract::New, post-genomic analyses are increasing the rate at which information about highly complex processes such as bacterial growth and development can be acquired. The recent use of DNA-microarray and proteomic analysis to study the differentiating bacterium Caulobacter crescentus has provided the first global view of th...

    journal_title:Trends in microbiology

    pub_type: 新闻

    doi:10.1016/s0966-842x(01)02135-7

    authors: Brun YV

    更新日期:2001-09-01 00:00:00

  • The causes and consequences of genetic variation in dengue virus.

    abstract::Despite the fact that dengue is one of the most prevalent viral infections of humans, the mechanisms responsible for its pathogenesis remain uncertain. Evolutionary studies of dengue virus have revealed that its genetic diversity is increasing. This, coupled with evidence that viral strains could naturally differ in v...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/s0966-842x(99)01669-8

    authors: Holmes EC,Burch SS

    更新日期:2000-02-01 00:00:00

  • Virulence mechanisms and host specificity of gall-forming Pantoea agglomerans.

    abstract::Pantoea agglomerans has been transformed from a commensal bacterium associated with many plants into a host-specific gall-forming pathogen by acquiring a plasmid-borne pathogenicity island. This pathogenicity island harbors the hrp/hrc gene cluster, in addition to genes encoding type III effector proteins, biosynthesi...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2007.10.009

    authors: Barash I,Manulis-Sasson S

    更新日期:2007-12-01 00:00:00

  • Oxygen-utilizing reactions and symbiotic colonization of the squid light organ by Vibrio fischeri.

    abstract::A major goal in microbiology is to understand the processes by which bacteria successfully colonize host tissue. Although a wealth of studies focusing on pathogenic microorganisms has revealed much about the rare interactions that result in disease, far less is known about the regulation of the ubiquitous, long-term, ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/s0966-842x(99)01588-7

    authors: Ruby EG,McFall-Ngai MJ

    更新日期:1999-10-01 00:00:00

  • Cell Death Pathway That Monitors Spore Morphogenesis.

    abstract::The use of quality control mechanisms to stall developmental pathways or completely remove defective cells from a population is a widespread strategy to ensure the integrity of morphogenetic programs. Endospore formation (sporulation) is a well conserved microbial developmental strategy in the Firmicutes phylum wherei...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2017.03.005

    authors: Decker AR,Ramamurthi KS

    更新日期:2017-08-01 00:00:00

  • Supertrees and symbiosis in eukaryote genome evolution.

    abstract::If we took all of the single copy genes in all sequenced genomes, made phylogenetic trees from them individually, and then made the supertree of those trees, what would we get? Recently, David Pisani and colleagues did that experiment and their results are likely to spark much discussion. Their prokaryote tree looks v...

    journal_title:Trends in microbiology

    pub_type: 杂志文章

    doi:10.1016/j.tim.2007.09.001

    authors: Esser C,Martin W

    更新日期:2007-10-01 00:00:00

  • Contribution of the Mucosal Microbiota to Bovine Respiratory Health.

    abstract::Recognizing the respiratory tract as a dynamic and complex ecosystem has enhanced our understanding of the pathophysiology of bovine respiratory disease (BRD). There is widespread evidence showing that disease-predisposing factors often disrupt the respiratory microbial ecosystem, provoking atypical colonization patte...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2019.04.005

    authors: Zeineldin M,Lowe J,Aldridge B

    更新日期:2019-09-01 00:00:00

  • Strategies of the home-team: symbioses exploited for vector-borne disease control.

    abstract::Symbioses between eukaryotes and unicellular organisms are quite common, with examples copiously disseminated throughout the earth's biota. Arthropods, in particular, owe much of their ecological success to their microbial flora, which often provide supplements either lacking in the limited host diet or which the host...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2004.05.001

    authors: Rio RV,Hu Y,Aksoy S

    更新日期:2004-07-01 00:00:00

  • How is the intracellular fate of the Legionella pneumophila phagosome determined?

    abstract::The following pair of articles, the first by Gil Segal and Howard Shuman, and the second by James Kirby and Ralph Isberg (Trends Microbiol. 6, 256-258), explore the genetics and function of the icm/dot genes of Legionella pneumophila. This gene family is implicated in several aspects of virulence and appears to consti...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/s0966-842x(98)01308-0

    authors: Segal G,Shuman HA

    更新日期:1998-07-01 00:00:00

  • Flipping the switch: bringing order to flagellar assembly.

    abstract::The bacterial flagellum is a complex self-assembling nanomachine that contains its own type III protein export apparatus. Upon completion of early flagellar structure, this apparatus switches substrate specificity to export late structural subunits, thereby coupling sequential flagellar gene expression with flagellar ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2006.10.006

    authors: Ferris HU,Minamino T

    更新日期:2006-12-01 00:00:00

  • Household Transmission of Influenza Virus.

    abstract::Human influenza viruses cause regular epidemics and occasional pandemics with a substantial public health burden. Household transmission studies have provided valuable information on the dynamics of influenza transmission. We reviewed published studies and found that once one household member is infected with influenz...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2015.10.012

    authors: Tsang TK,Lau LLH,Cauchemez S,Cowling BJ

    更新日期:2016-02-01 00:00:00

  • Cytopathic effects: virus-modulated manifestations of innate immunity?

    abstract::The capacity to injure infected cells is a widespread property of viruses. Usually, this cytopathic effect (CPE) is ascribed to viral hijacking of cellular resources to fulfill viral needs. However, evidence is accumulating that CPE is not necessarily directly coupled to viral reproduction but may largely be due to ho...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2012.09.003

    authors: Agol VI

    更新日期:2012-12-01 00:00:00

  • Type III secretion à la Chlamydia.

    abstract::Type III secretion (T3S) is a mechanism that is central to the biology of the Chlamydiaceae and many other pathogens whose virulence depends on the translocation of toxic effector proteins to cytosolic targets within infected eukaryotic cells. Biomathematical simulations, using a previously described model of contact-...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2007.04.005

    authors: Peters J,Wilson DP,Myers G,Timms P,Bavoil PM

    更新日期:2007-06-01 00:00:00

  • Survival strategies of infectious biofilms.

    abstract::Modern medicine is facing the spread of biofilm-related infections. Bacterial biofilms are difficult to detect in routine diagnostics and are inherently tolerant to host defenses and antibiotic therapies. In addition, biofilms facilitate the spread of antibiotic resistance by promoting horizontal gene transfer. We rev...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2004.11.010

    authors: Fux CA,Costerton JW,Stewart PS,Stoodley P

    更新日期:2005-01-01 00:00:00

  • Positive Interactions in the Coral Macro and Microbiome.

    abstract::Researchers now recognize the importance of the coral microbiome, but they often overlook other species that live on corals and influence coral-microbe interactions. These 'interstitial associates' should be incorporated into the metaorganism concept for insights into how facilitations between associates, corals, and ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章

    doi:10.1016/j.tim.2020.02.009

    authors: Ainsworth TD,Renzi JJ,Silliman BR

    更新日期:2020-08-01 00:00:00

  • Intestinal epithelial cells as watchdogs for the natural immune system.

    abstract::Intestinal epithelial cells secrete a spectrum of chemoattractant and proinflammatory cytokines after invasion by bacteria. We suggest the novel concept that epithelial cells not only act as a mechanical barrier to invasive bacteria, but that they also signal the presence of invasive pathogens to the mucosal immune an...

    journal_title:Trends in microbiology

    pub_type: 杂志文章

    doi:10.1016/s0966-842x(00)88894-0

    authors: Eckmann L,Kagnoff MF,Fierer J

    更新日期:1995-03-01 00:00:00

  • Herpesvirus genetics has come of age.

    abstract::The genetic analysis of the large and complex herpesviruses has been a constant challenge to herpesvirologists. Elegant methods have been developed to produce mutants in infected cells that rely on the cellular recombination machinery. Bacterial artificial chromosomes (BACs), single copy F-factor-based plasmid vectors...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/s0966-842x(02)02394-6

    authors: Wagner M,Ruzsics Z,Koszinowski UH

    更新日期:2002-07-01 00:00:00

  • Noncoding RNAs: Regulatory Molecules of Host-Microbiome Crosstalk.

    abstract::Recent emerging evidence has revealed that regulatory noncoding RNAs (microRNAs, circular RNAs) modulate host-microbe interactions and they have been proposed as potential biomarkers of the host's response to microbiome-linked pathologies such as cancers, obesity, and neurodegenerative diseases. Interactions between m...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2020.12.003

    authors: Malmuthuge N,Guan LL

    更新日期:2021-01-05 00:00:00

  • Progress in functional genomics approaches to antifungal drug target discovery.

    abstract::Antifungal drug discovery is starting to benefit from the enormous advances in the genomics field, which have occurred in the past decade. As traditional drug screening on existing targets is not delivering the long-awaited potent antifungals, efforts to use novel genetics and genomics-based strategies to aid in the d...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2003.08.008

    authors: De Backer MD,Van Dijck P

    更新日期:2003-10-01 00:00:00

  • Inhibitors of HIV-1 transcription.

    abstract::No curative drug against HIV has yet been found, despite enormous efforts aimed at reverse transcriptase and a variety of other targets. The long terminal repeat (LTR) of HIV-1 has recently become a promising site for antiviral action. This article briefly summarizes information on the nature of this target and potent...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/0966-842x(94)90666-1

    authors: Li CJ,Dezube BJ,Biswas DK,Ahlers CM,Pardee AB

    更新日期:1994-05-01 00:00:00

  • Processing and export of peptide pheromones and bacteriocins in Gram-negative bacteria.

    abstract::Cell-density-dependent gene expression is widespread in bacteria and is mediated by extracellular communication molecules. Gram-negative bacteria often use N-acyl homoserine lactones, whereas cell-cell signaling in Gram-positive bacteria is accomplished using post-translationally processed peptide pheromones. In many ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/s0966-842x(01)01979-5

    authors: Michiels J,Dirix G,Vanderleyden J,Xi C

    更新日期:2001-04-01 00:00:00

  • Structure, function and stability of enzymes from the Archaea.

    abstract::The Archaea include microorganisms growing in some of the most extreme environments on earth. Consequently, their cellular components are remarkably stable entities and have considerable potential in the biotechnology industry. Here, we review the structure of archaeal enzymes in the context of their ability to functi...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/s0966-842x(98)01316-x

    authors: Danson MJ,Hough DW

    更新日期:1998-08-01 00:00:00

  • Demystifying Cell Cycle Arrest by HIV-1 Vif.

    abstract::Although APOBEC3 degradation is the canonical function of HIV-1 Vif, this viral protein also induces potent cell cycle arrest through a newly defined mechanism. Here, we review recent advances in this area and propose that the scope of this activity may go beyond subversion of the host cell cycle. ...

    journal_title:Trends in microbiology

    pub_type: 杂志文章

    doi:10.1016/j.tim.2021.01.001

    authors: Salamango DJ,Harris RS

    更新日期:2021-01-19 00:00:00

  • Candida albicans hyphal initiation and elongation.

    abstract::The fungus Candida albicans is a benign member of the mucosal microbiota, but can cause mucosal infections and life-threatening disseminated invasive infections in susceptible individuals. The ability to switch between yeast, pseudohyphal, and hyphal growth forms (polymorphism) is one of the most investigated virulenc...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2014.09.001

    authors: Lu Y,Su C,Liu H

    更新日期:2014-12-01 00:00:00

  • Antibodies against Candida: potential therapeutics?

    abstract::For many years, there has been controversy over the role of antibodies in immunity to Candida, but recently specific antibodies to mannoproteins and hsp90 have been shown to be protective against murine candidiasis. Combined with technical advances in antibody engineering, this raises the possibility of harnessing suc...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/0966-842x(96)10056-1

    authors: Matthews R,Burnie J

    更新日期:1996-09-01 00:00:00

  • Integrated Signaling Pathways Mediate Bordetella Immunomodulation, Persistence, and Transmission.

    abstract::The mammalian immune system includes a sophisticated array of antimicrobial mechanisms. However, successful pathogens have developed subversive strategies to detect, modulate, and/or evade immune control and clearance. Independent disciplines study host immunology and bacterial pathogenesis, but interkingdom signaling...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2018.09.010

    authors: Gestal MC,Whitesides LT,Harvill ET

    更新日期:2019-02-01 00:00:00

  • Oxygen-dependent anti-Salmonella activity of macrophages.

    abstract::Numerous observations have established a crucial role for phagocytic cells in host resistance to Salmonella. Activated macrophages rely on a complex array of oxygen-dependent antimicrobial molecules to inhibit or kill intracellular Salmonella. An initial oxidative bactericidal phase, which is dependent on the respirat...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/s0966-842x(00)01897-7

    authors: Vazquez-Torres A,Fang FC

    更新日期:2001-01-01 00:00:00

  • Correlating ribosome function with high-resolution structures.

    abstract::Ribosome research has undergone astonishing progress in recent years. Crystal structures have shed light on the functional properties of the translation machinery and revealed how the striking architecture of the ribosome is ingeniously designed as the framework for its unique capabilities: precise decoding, substrate...

    journal_title:Trends in microbiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.tim.2008.05.001

    authors: Bashan A,Yonath A

    更新日期:2008-07-01 00:00:00