Abstract:
:The polysaccharide-rich wall, which envelopes the fungal cell, is pivotal to the maintenance of cellular integrity and for the protection of the cell from external aggressors - such as environmental fluxes and during host infection. This review considers the commonalities in the composition of the wall across the fungal kingdom, addresses how little is known about the assembly of the polysaccharide matrix, and considers changes in the wall of plant-pathogenic fungi during on and in planta growth, following the elucidation of infection structures requiring cell wall alterations. It highlights what is known about the phytopathogenic fungal wall and what needs to be discovered.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Geoghegan I,Steinberg G,Gurr Sdoi
10.1016/j.tim.2017.05.015subject
Has Abstractpub_date
2017-12-01 00:00:00pages
957-967issue
12eissn
0966-842Xissn
1878-4380pii
S0966-842X(17)30133-6journal_volume
25pub_type
杂志文章,评审abstract::Microbial dormancy is a widespread phenomenon employed by bacteria to evade environmental threats including antibiotics. This intrinsic mechanism of antibiotic tolerance has drawn special attention to the role of dormancy in human disease, particularly in regards to recurrent infections. Two dormancy states, the viabl...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2014.09.004
更新日期:2015-01-01 00:00:00
abstract::Key skills such as communication and critical thinking are essential for today's microbiology graduate. There are many opportunities within the undergraduate curriculum to help students to use, develop and appreciate their own unique set of skills. This article describes personal experiences of research-led teaching a...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2009.12.006
更新日期:2010-02-01 00:00:00
abstract::Persistence of the latent reservoir remains a challenge to curing HIV infection. Using shRNA screening, new insights into the molecular mechanisms underlying latency regulation indicate that the estrogen receptor is a potent repressor of proviral reactivation and may serve as a promising therapeutic target in combinat...
journal_title:Trends in microbiology
pub_type: 评论,杂志文章
doi:10.1016/j.tim.2018.09.005
更新日期:2018-11-01 00:00:00
abstract::Virulence of many bacterial pathogens is based, at least in part, on the action of phospholipases. The consequences may be immediate and direct, as in the action of Clostridium perfringens alpha toxin on red cells or platelets, or subtle, as with phosphatidylinositol-specific phospholipases of Listeria monocytogenes a...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/S0966-842X(97)01005-6
更新日期:1997-04-01 00:00:00
abstract::Nasopharyngeal carcinoma is a human malignancy consistently associated with the Epstein-Barr virus. Exposure to non-viral carcinogens and genetic predisposition are other crucial etiologic factors. Tumor development appears to require the expression of a small subset of transforming viral RNAs and proteins with concom...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2004.06.005
更新日期:2004-08-01 00:00:00
abstract::Bacteria must segregate their DNA and position a septum to grow and divide. In many bacteria, MinD is involved in spatial regulation of the cytokinetic Z ring, and ParAs are involved in chromosome and plasmid segregation. The use of the MinD/ParA family to provide positional information for spatial organization contin...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2012.05.002
更新日期:2012-09-01 00:00:00
abstract::To enhance infection, enveloped viruses exploit adhesion molecules expressed on the surface of host cells. Specifically, phosphatidylserine (PS) receptors - including members of the human T cell immunoglobulin and mucin domain (TIM)-family - have gained attention for their ability to mediate the entry of many envelope...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2019.10.004
更新日期:2020-03-01 00:00:00
abstract::The identification and quantification of the proteins that a whole organism expresses under certain conditions is a main focus of high-throughput proteomics. Advanced proteomics approaches generate new biologically relevant data and potent hypotheses. A practical report of what proteome studies can and cannot accompli...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2006.03.005
更新日期:2006-05-01 00:00:00
abstract::Hepatitis C virus populations in infected individuals consist of quasispecies with diverse mutations. These quasispecies have different biological properties, and the analysis of these variants has led to new interpretations of viral persistence, carcinogenesis and resistance to interferon therapy. ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/s0966-842x(00)89000-9
更新日期:1995-11-01 00:00:00
abstract::The discovery of 'molecular syringes' in several important gastrointestinal pathogens including Escherichia coli, Salmonella, Shigella and Yersinia, together with a better understanding of M cells and the mucosal immune system, has advanced our appreciation of multistage microorganism-host cell interactions. Recent st...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/s0966-842x(00)01828-x
更新日期:2000-10-01 00:00:00
abstract::Pseudomonas aeruginosa (PA) uses several virulence factors to establish chronic respiratory infections in bronchiectasis, chronic obstructive pulmonary disease, and cystic fibrosis (CF) patients. One of its toxins, pyocyanin (PYO), is a redox-active pigment that is required for full virulence in animal models and has ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2012.10.004
更新日期:2013-02-01 00:00:00
abstract::The STING (Stimulator of Interferon Genes) protein connects microorganism cytosolic sensing with effector functions of the host cell by sensing directly cyclic dinucleotides (CDNs), originating from pathogens or from the host upon DNA recognition. Although STING activation favors effective immune responses against vir...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2017.05.008
更新日期:2017-11-01 00:00:00
abstract::DNA vaccines can induce potent humoral and cellular immune responses without any additional adjuvant. Recent studies indicate that unmethylated CpG dinucleotides within DNA vaccines are immune stimulatory and exert an essential endogenous adjuvant activity. These CpG motifs can be added deliberately to DNA or conventi...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/S0966-842X(97)01145-1
更新日期:1998-01-01 00:00:00
abstract::A holistic approach to understanding the mechanisms by which stress influences the pathogenesis of infectious disease has resulted in the development of the field of microbial endocrinology. This transdisciplinary field represents the intersection of microbiology with mammalian endocrinology and neurophysiology, and i...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2007.11.005
更新日期:2008-02-01 00:00:00
abstract::Recently, a new group of multicellular microorganisms was discovered, called 'cable bacteria', which are capable of generating and mediating electrical currents across centimetre-scale distances. By transporting electrons from cell to cell, cable bacteria can harvest electron donors and electron acceptors that are wid...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2017.10.011
更新日期:2018-05-01 00:00:00
abstract::The term 'type III secretion' has seen widespread use. However, problems persist in nomenclature. We propose that the standard abbreviation for this kind of secretion should be 'T3S' and that 'type III secretion system' should be abbreviated to 'T3SS'. There is also a need for a new terminology to distinguish flagella...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2006.02.009
更新日期:2006-04-01 00:00:00
abstract::Hospitals worldwide are facing an increasing incidence of hard-to-treat infections. Limiting infections and providing patients with optimal drug regimens require timely strain identification as well as virulence and drug-resistance profiling. Additionally, prophylactic interventions based on the identification of envi...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2018.08.004
更新日期:2018-12-01 00:00:00
abstract::Pathogenic Yersinia express a complex array of iron-regulated functions and possess mechanisms for inorganic iron and hemin acquisition. These include a unique temperature-regulated hemin storage system, high-affinity transport processes for hemin and inorganic iron, and an iron-responsive regulatory system controllin...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/0966-842x(93)90129-f
更新日期:1993-07-01 00:00:00
abstract::Many proteins are transported to the cell surface of Saccharomyces cerevisiae and Candida albicans to be either integrated into the cell-wall structure or exported to the external medium. Secretion of many of these proteins through the classical endoplasmic reticulum-Golgi pathway is driven by a canonical N-terminal s...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2005.11.009
更新日期:2006-01-01 00:00:00
abstract::The intestine harbors an ecosystem composed of the intestinal mucosa and the commensal microbiota. The microbiota fosters development, aids digestion and protects host cells from pathogens - a function referred to as colonization resistance. Little is known about the molecular basis of colonization resistance and how ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2007.12.008
更新日期:2008-03-01 00:00:00
abstract::Progress in understanding the evolution of infectious diseases has inspired proposals to manage the evolution of pathogen (including parasite) virulence. A common view is that social interventions that lower pathogen transmission will indirectly select lower virulence because of a trade-off between transmission and vi...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/s0966-842x(02)00003-3
更新日期:2003-01-01 00:00:00
abstract::An individual's microbiome is likely to be an important contributor to certain health disparity diseases and conditions. We present a framework to study the role of the microbiome and the multiple factors that are likely to influence differences in disease predisposition, onset, and progression at the individual and p...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2016.08.001
更新日期:2016-11-01 00:00:00
abstract::Staphylococcus aureus is a major cause of bacteraemia, which frequently leads to infective endocarditis, osteomyelitis, septic arthritis and metastatic abscess formation. The development of these secondary infections is due to bacterial dissemination from the blood into surrounding tissues and is associated with signi...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2010.12.005
更新日期:2011-04-01 00:00:00
abstract::Rolling circle DNA replication is inherently continuous and unregulated. This 'go-for-broke' strategy works well for lytic phages but is suicidal for plasmids that must coexist with their host. Plasmids have consequently evolved elaborate copy number control systems that operate at the transcriptional, translational a...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/S0966-842X(97)01143-8
更新日期:1997-11-01 00:00:00
abstract::Toxin production clearly contributes to the pathogenesis of Staphylococcus aureus, but that does not mean it is always in the best interest of the pathogen. Indeed, the ability to limit toxin production may provide an important mechanism for persistence, dissemination, and development of invasive disease within an ind...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2016.07.003
更新日期:2016-09-01 00:00:00
abstract::Rhizobia are soil bacteria that can become endosymbionts, reducing atmospheric nitrogen within nodules formed on the roots of legume plants. During tissue and cell invasion, bacterial cell-surface components adapt the bacterium to survive as an endophyte without eliciting host-defence responses. The structures of many...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/0966-842x(94)90004-3
更新日期:1994-08-01 00:00:00
abstract::The Archaea include microorganisms growing in some of the most extreme environments on earth. Consequently, their cellular components are remarkably stable entities and have considerable potential in the biotechnology industry. Here, we review the structure of archaeal enzymes in the context of their ability to functi...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/s0966-842x(98)01316-x
更新日期:1998-08-01 00:00:00
abstract::The use of β-lactam antibiotics to treat infections caused by Staphylococcus aureus has been severely compromised by the acquisition by horizontal gene transfer of a gene that encodes the β-lactam-insensitive penicillin-binding protein PBP2a. This allows methicillin-resistant S. aureus (MRSA) to proliferate in the pre...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2018.06.005
更新日期:2019-01-01 00:00:00
abstract::Ribosome research has undergone astonishing progress in recent years. Crystal structures have shed light on the functional properties of the translation machinery and revealed how the striking architecture of the ribosome is ingeniously designed as the framework for its unique capabilities: precise decoding, substrate...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2008.05.001
更新日期:2008-07-01 00:00:00
abstract::Two recent studies have provided the most complete screen for protein complexes in yeast to date, in which partners were identified for approximately half of the proteome. A comparison shows that these two datasets are complementary. In addition, one of the analyses points to a modular organization of the cellular pro...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2006.06.002
更新日期:2006-08-01 00:00:00