Abstract：
:The actin cytoskeleton plays a key role during the replication cycle of human immunodeficiency virus-1 (HIV-1). HIV-1 infection is affected by cellular proteins that influence the clustering of viral receptors or the subcortical actin cytoskeleton. Several of these actin-adaptor proteins are controlled by the second messenger phosphatidylinositol 4,5-biphosphate (PIP2), an important regulator of actin organization. PIP2 production is induced by HIV-1 attachment and facilitates viral infection. However, the importance of PIP2 in regulating cytoskeletal proteins and thus HIV-1 infection has been overlooked. This review examines recent reports describing the roles played by actin-adaptor proteins during HIV-1 infection of CD4+ T cells, highlighting the influence of the signaling lipid PIP2 in this process.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
Rocha-Perugini V,Gordon-Alonso M,Sánchez-Madrid Fdoi
10.1016/j.tim.2014.03.009subject
Has Abstractpub_date
2014-07-01 00:00:00pages
379-88issue
7eissn
0966-842Xissn
1878-4380pii
S0966-842X(14)00071-7journal_volume
22pub_type
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更新日期：2006-04-01 00:00:00
