Virus-like particles as immunogens.

abstract：:Cervical cancer is the third most common cancer in women with human papillomavirus (HPV) being a key etiologic factor of this devastating disease. In this article, we describe modern advances in the genomics and transcriptomics of cervical cancer that led to uncovering the key gene drivers. We also introduce, herein, ...

journal_title：Trends in microbiology

authors： Shulzhenko N,Lyng H,Sanson GF,Morgun A

更新日期：2014-06-01 00:00:00

abstract：:The following pair of articles, the first by Gil Segal and Howard Shuman, and the second by James Kirby and Ralph Isberg (Trends Microbiol. 6, 256-258), explore the genetics and function of the icm/dot genes of Legionella pneumophila. This gene family is implicated in several aspects of virulence and appears to consti...

journal_title：Trends in microbiology

authors： Segal G,Shuman HA

更新日期：1998-07-01 00:00:00

abstract：:The rumen of sheep and cattle represents a mobile, self-sustaining fermentation system for plant material. Analysis of the rumen flora continues to provide fundamental knowledge of anaerobic microbiology and is now yielding microbial genes that have potential in biotechnology. Recent research has provided fascinating ...

journal_title：Trends in microbiology

authors： Flint HJ

更新日期：1997-12-01 00:00:00

abstract：:Rhizobia are soil bacteria that can become endosymbionts, reducing atmospheric nitrogen within nodules formed on the roots of legume plants. During tissue and cell invasion, bacterial cell-surface components adapt the bacterium to survive as an endophyte without eliciting host-defence responses. The structures of many...

journal_title：Trends in microbiology

authors： Kannenberg EL,Brewin NJ

更新日期：1994-08-01 00:00:00

abstract：:No curative drug against HIV has yet been found, despite enormous efforts aimed at reverse transcriptase and a variety of other targets. The long terminal repeat (LTR) of HIV-1 has recently become a promising site for antiviral action. This article briefly summarizes information on the nature of this target and potent...

journal_title：Trends in microbiology

authors： Li CJ,Dezube BJ,Biswas DK,Ahlers CM,Pardee AB

更新日期：1994-05-01 00:00:00

abstract：:The bacterial type IV pilus (T4P) is a versatile molecular machine with a broad range of functions. Recent advances revealed that the molecular components and the biophysical properties of the machine are well conserved among phylogenetically distant bacterial species. However, its functions are diverse, and include a...

journal_title：Trends in microbiology

authors： Maier B,Wong GCL

更新日期：2015-12-01 00:00:00

abstract：:Although it is commonly assumed that Darwin had nothing to say about microbes, he did in fact say quite a lot. He included microbes in his Beagle studies of the geographical distribution of organisms and used microscopic organisms as explicit exemplars of how adaptation did not imply increasing complexity. Darwin ofte...

journal_title：Trends in microbiology

authors： O'Malley MA

更新日期：2009-08-01 00:00:00

abstract：:Cell-density-dependent gene expression is widespread in bacteria and is mediated by extracellular communication molecules. Gram-negative bacteria often use N-acyl homoserine lactones, whereas cell-cell signaling in Gram-positive bacteria is accomplished using post-translationally processed peptide pheromones. In many ...

journal_title：Trends in microbiology

authors： Michiels J,Dirix G,Vanderleyden J,Xi C

更新日期：2001-04-01 00:00:00

abstract：:Knockout mice with distinct gene deletions are valuable tools for in vivo analyses of the immune response against infectious agents. Studies of bacterial and protozoal infections have shown that antimicrobial immunity is generally defective in knockout mice. At one extreme, deletion of just one gene may completely com...

journal_title：Trends in microbiology

authors： Kaufmann SH,Ladel CH

更新日期：1994-07-01 00:00:00

abstract：:Mycobacterium leprae has the capacity to invade the peripheral nervous system and cause neuropathy. The molecular mechanisms responsible have remained unknown until recently. Identification of the endoneurial laminin-2 isoform and its receptor alpha-dystroglycan as neural targets of M. leprae has not only opened up a ...

journal_title：Trends in microbiology

authors： Rambukkana A

更新日期：2000-01-01 00:00:00

abstract：:Nasopharyngeal carcinoma is a human malignancy consistently associated with the Epstein-Barr virus. Exposure to non-viral carcinogens and genetic predisposition are other crucial etiologic factors. Tumor development appears to require the expression of a small subset of transforming viral RNAs and proteins with concom...

journal_title：Trends in microbiology

authors： Busson P,Keryer C,Ooka T,Corbex M

更新日期：2004-08-01 00:00:00

abstract：:New, post-genomic analyses are increasing the rate at which information about highly complex processes such as bacterial growth and development can be acquired. The recent use of DNA-microarray and proteomic analysis to study the differentiating bacterium Caulobacter crescentus has provided the first global view of th...

journal_title：Trends in microbiology

authors： Brun YV

更新日期：2001-09-01 00:00:00

abstract：:The evolution of virulence in Salmonella is driven by horizontal gene transfer. This has given rise to highly flexible pathogens that are able to colonize new niches and extend their host range. Tracing the record of horizontal gene transfer can provide clues to the virulence factors that contribute to the formation o...

journal_title：Trends in microbiology

authors： Bäumler AJ

更新日期：1997-08-01 00:00:00

abstract：:It is usually assumed that most prokaryotes, when given appropriate nutrients, can grow and divide in the absence of other cells of the same species. However, recent studies have suggested that, for growth, prokaryotes need to communicate with each other using signalling molecules, and a variety of 'eukaryotic' hormon...

journal_title：Trends in microbiology

authors： Kaprelyants AS,Kell DB

更新日期：1996-06-01 00:00:00

abstract：:Enveloped viruses encode membrane-associated glycoproteins that direct the initial stages of virus infection. These usually oligomeric structures bind virions to cell surface receptors and, subsequently, direct fusion of viral membranes with cellular membranes. These structures are also the primary targets of neutrali...

journal_title：Trends in microbiology

authors： Morrison TG

更新日期：2001-03-01 00:00:00

abstract：:Human T-lymphotropic virus type 1 (HTLV-1) is an exogenous retrovirus that persists lifelong in the infected host. Infection has been linked to a spectrum of diverse diseases: adult T cell leukemia, encephalomyelopathy, and predisposition to opportunistic bacterial and helminth infections. Applications of new technolo...

journal_title：Trends in microbiology

authors： Tattermusch S,Bangham CR

更新日期：2012-10-01 00:00:00

abstract：:For decades, hemagglutinin (HA) protein structure and its refolding mechanism have served as a paradigm for understanding protein-mediated membrane fusion. HA trimers are in a high-energy state and are functionally activated by low pH. Over the past decade, HA stability (or the pH at which irreversible conformational ...

journal_title：Trends in microbiology

authors： Russell CJ,Hu M,Okda FA

更新日期：2018-10-01 00:00:00

abstract：:Understanding how asymmetries in cellular constituents are achieved and how such positional information directs the construction of structures in a nonrandom fashion is a fundamental problem in cell biology. The recent identification of determinants that self-assemble into macromolecular complexes at the bacterial cel...

journal_title：Trends in microbiology

authors： Bergé M,Viollier PH

更新日期：2018-04-01 00:00:00

abstract：:Filamentous phages are small, highly evolved parasites that can reproduce and disseminate without killing their host. During assembly, virion proteins are transferred from the host membrane to the single-stranded DNA phase genome and simultaneously secreted from the cell. Filamentous phage assembly shares certain feat...

journal_title：Trends in microbiology

authors： Russel M

更新日期：1995-06-01 00:00:00

abstract：:Detection of pathogen-derived nucleic acids by pattern recognition receptors (PRRs) is essential for the host to mount an appropriate immune response, which for viruses involves the induction of type I interferons (IFNs). By contrast, inappropriate activation of PRRs by self nucleic acids can lead to autoimmunity. Rec...

journal_title：Trends in microbiology

authors： Gürtler C,Bowie AG

更新日期：2013-08-01 00:00:00

abstract：:H3N2-subtype influenza A viruses are major causes of seasonal influenza epidemics. Emerging H3N2 variants require the annual adjustment of the vaccine strain. Recently, studies addressing the reduced effectiveness of current H3N2 vaccines have identified production-related substitutions in the viral hemagglutinin anti...

journal_title：Trends in microbiology

authors： Mostafa A,Pleschka S

更新日期：2018-02-01 00:00:00

abstract：:Proteins embedded in membranes are important for helping the cell adapt to changes in the extracellular milieu and often play key roles in the life cycles of pathogenic microbes. Bioinformatic predictions can provide an estimate of membrane proteins, but experimental approaches of detection are required for a deeper u...

journal_title：Trends in microbiology

authors： Bernsel A,Daley DO

更新日期：2009-10-01 00:00:00

abstract：:Fluorescent amino acid analogs have proven to be useful tools for studying the dynamics of peptidoglycan metabolism. García-Heredia and colleagues showed that their route of incorporation differs depending on the adjunct fluorophore and applied this property to investigate mycobacterial peptidoglycan synthesis and rem...

journal_title：Trends in microbiology

authors： Botella H,Vaubourgeix J

更新日期：2019-01-01 00:00:00

abstract：:The existence of a peptidoglycan cell wall in chlamydiae has been debated for several years. Several studies suggest that these organisms synthesize a cell wall, but some of the components and biosynthetic machinery seem to be missing and a bona fide cell wall has yet to be described. A recent study has revealed that ...

journal_title：Trends in microbiology

authors： Pavelka MS Jr

更新日期：2007-04-01 00:00:00

abstract：:Evolutionarily related multisubunit RNA polymerases (RNAPs) facilitate gene transcription throughout the three domains of life. During the past seven years an increasing number of bacterial and eukaryotic RNAP structures have been solved; however, the archaeal enzyme remained elusive. Two reports from the Murakami and...

journal_title：Trends in microbiology

authors： Werner F

更新日期：2008-06-01 00:00:00

abstract：:The formation of biofilms is initiated by bacteria transitioning from the planktonic to the surface-associated mode of growth. Several regulatory systems have been described to govern the initiation and subsequent formation of biofilms. Recent evidence suggests that regulatory networks governing the decision of bacter...

journal_title：Trends in microbiology

authors： Chambers JR,Sauer K

更新日期：2013-01-01 00:00:00

abstract：:The ubiquitin-26S proteasome degradation system (UPS) plays a pivotal role in almost all aspects of plant life, including defending against pathogens. Although the proteasome is important for plant immunity, it has been found to be also exploited by pathogens using effectors to increase their virulence. Recent work on...

journal_title：Trends in microbiology

authors： Dudler R

更新日期：2014-01-01 00:00:00

abstract：:Haemolytic uraemic syndrome (HUS), which is caused by Shiga toxin (Stx)-producing Escherichia coli, is the commonest cause of acute renal failure in childhood. It is widely believed that HUS develops following the release of Stx, an AB5 toxin that inhibits protein synthesis and has a direct toxic effect on the kidney ...

journal_title：Trends in microbiology

authors： Heyderman RS,Soriani M,Hirst TR

更新日期：2001-06-01 00:00:00

abstract：:Genome analyses of double strand DNA tailed bacteriophages argue that they evolve by recombinational reassortment of genes and by the acquisition of novel genes as simple genetic elements termed morons. These processes suggest a model for early virus evolution, wherein viruses can be regarded less as having derived fr...

journal_title：Trends in microbiology

authors： Hendrix RW,Lawrence JG,Hatfull GF,Casjens S

更新日期：2000-11-01 00:00:00

abstract：:Bacteriophages are viruses of bacteria that are used for controlling bacterial food-borne pathogens and have been proposed for more extensive usage in infection control. Protists are now recognised to harbour viruses and virus-like particles. We propose that investigation of their prevalence in parasites be intensifie...

journal_title：Trends in microbiology

authors： Hyman P,Atterbury R,Barrow P

更新日期：2013-05-01 00:00:00