Abstract:
:Wistar rats were selectively bred over 10 generations for differences in performance in a footshock-motivated brightness discrimination (BD) test in a Y-maze. High behavioral performance (Wis/HBP) and low behavioral performance (Wis/LBP) rat lines were obtained which differ significantly in all behavioral components tested: frequency of correct responses, number of trials to criterion, response latency (HBP less than LBP), and frequency of freezing behavior (HBP less than LBP), the latter suggesting differences in emotionality. In Wis/LBP rats, furthermore, the normal increase in behavioral performance between the training and the relearning session, which indicates the formation of a memory trace, disappeared during selection. In male breeders sampled during selection of the two lines (Wis/HBP: n = 17; Wis/LBP: n = 21), both arginine vasopressin (AVP) and oxytocin (OXT) contents were measured by radioimmunoassay in the motor cortex, septum/striatum, hippocampus, hypothalamus, medulla oblongata and posterior pituitary. Compared with the Wis/HBP rats, the Wis/LBP rats contained less AVP in the hippocampus (3.1 +/- 0.58 vs 8.3 +/- 1.4 pg/mg wet wt., mean +/- S.E.M., P less than 0.001), but more AVP in the medulla (1.7 +/- 0.20 vs 1.1 +/- 0.18 pg/mg, P less than 0.05). In contrast, no significant differences between the lines were detected with respect to OXT concentrations. In the Wis/LBP rats, moreover, the hippocampal AVP content decreased during selection (r = -0.645, P less than 0.01), while the acquisition response latency increased (r = 0.549, P less than 0.01). As a consequence, a significant, albeit weak, negative correlation (r = -0.483, P less than 0.05) was observed between the individual hippocampal AVP content and the response latency during acquisition. Thus, the results confirm the view that genetically determined differences in the hippocampal content of endogenous AVP may contribute to an individual's level of emotionality and behavioral performance.
journal_name
Brain Resjournal_title
Brain researchauthors
Hess J,Lesser D,Landgraf Rdoi
10.1016/0006-8993(92)90375-jsubject
Has Abstractpub_date
1992-01-08 00:00:00pages
106-11issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(92)90375-Jjournal_volume
569pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Glioblastoma multiform is the most common malignant primary brain tumor in adults, but there remains no effective therapeutic approach. 2-methoxyestradiol (2-ME), which is a naturally occurring metabolite of 17beta-estradiol, was shown to enhance radiotherapeutic effect in certain tumors; however, whether 2-ME can als...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.07.092
更新日期:2007-12-14 00:00:00
abstract::We used double-barreled pH-sensitive microelectrodes to study the mechanisms by which the intracellular pH is regulated in the connective glial cells of the medicinal leech. The experiments indicate that a Cl(-)- and HCO3(-)-dependent mechanism mediates some recovery from intracellular alkalosis even in the absence of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91144-4
更新日期:1994-11-28 00:00:00
abstract::Existing data on the expression of H(4) histamine receptor in the CNS are conflicting and inconclusive. In this report, we present the results of experiments that were conducted in order to elucidate H(4) receptor expression and localization in the brain, spinal cord, and dorsal root ganglia (DRG). Here we show that t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.11.018
更新日期:2009-01-23 00:00:00
abstract::The radioligand [125I]alpha-bungarotoxin (alpha-BTX) has been used to test receptor binding to putative nicotinic cholinergic receptors in the hypothalamus. Using light microscopic autoradiography following third ventricular infusion of the radioligand we have previously demonstrated that in normally cycling rats and ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90736-4
更新日期:1984-01-02 00:00:00
abstract::Explosive running is a reliable initial component of audiogenic seizures (AS) induced by acoustic stimulation in genetically prone rodents. This profound locomotor activation is usually considered as a convulsive manifestation of AS although some studies attribute running to a panic-like response. Increase in central ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.02.017
更新日期:2007-05-07 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF) is a well neurotrophic factor with neuroprotective potentials for various diseases in the central nervous system. However several previous studies demonstrated that BDNF might deteriorate symptoms for epilepsy model of animals by progression of abnormal neurogenesis. We hypothe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.10.054
更新日期:2011-01-12 00:00:00
abstract::Intravenous administration of the cholecystokinin (CCK) antagonist lorglumide (LORG) reversed chronic haloperidol (CHAL)-induced depolarization inactivation (DI) of dopamine (DA) cells in both the A9 and A10 areas. Moreover, microinjection of LORG, but not naloxone, directly into the medial nucleus accumbens (mNAc) do...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90330-7
更新日期:1988-11-08 00:00:00
abstract::We have investigated the receptor subtype(s) mediating the noradrenergic inhibition of cerebellar Purkinje cell spontaneous firing rate using local application of specific agonists and antagonists, in situ, via pressure microejection. Extracellular action potentials were recorded from Purkinje neurons in anesthetized ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90552-5
更新日期:1988-10-18 00:00:00
abstract::We studied the effects of axotomy or neurotoxin on the survival of substantia nigra pars compacta (SNpc) neurons in two strains of mice, FVB/N or C57BL/6. Fluoro gold (FG) was injected into both striata of the mice to retrogradely label the nigrostriatal neuronal population. Ten days later, these neurons were axotomiz...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.09.066
更新日期:2003-12-24 00:00:00
abstract::Genetic variability in the behavioral responses of experimental subjects to psychostimulants such as amphetamine and cocaine have been reported. However, genetic differences in the locomotor responses of rat strains to methylphenidate (MPD), a commonly used psychostimulant in the treatment of attention deficit/hyperac...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)04240-3
更新日期:2003-05-09 00:00:00
abstract::Although there are several reports on the alteration of intracellular signal transduction during heat shock in somatic cells, the long term effects of heat shock on neuronal cells remain unknown. In this report, we investigated cyclic AMP (cAMP) accumulation and the expression of heat shock proteins following heat sho...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00072-9
更新日期:1998-04-20 00:00:00
abstract::Extracellular recordings were conducted in the paraflocculus of anesthetized Long-Evans pigmented rats to determine how ionotophoresis of norepinephrine (NE) affects the responsiveness of individual Purkinje cells and interneurons to presentations of visual stimuli within their visual receptive fields. Presentations o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91421-c
更新日期:1990-04-30 00:00:00
abstract::Extracellular field recordings were made in CA1 in the hippocampal explant cultures in oxygenated artificial cerebrospinal fluid. Schaffer collaterals were stimulated with 1-s trains of 60 Hz pulses every 10 min. Seizures were reliably elicited with progressive lengthening over 1-2 h. D-APV, an N-methyl-D-aspartate (N...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91171-a
更新日期:1992-08-28 00:00:00
abstract::Normal adult albino and Sprague-Dawley rats, under intraperitoneal Nembutal anesthesia, were used to demonstrate enzymatic activity in the choroid plexus and ventricular ependyma. The brain tissues were perfused or immersed with cold 2% glutaraldehyde and 8% sucrose in 0.1 M cacodylate buffer (pH 7.2-7.4) for 30 min a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)91035-0
更新日期:1981-10-19 00:00:00
abstract::The effect of chronic ethanol administration on the density of basket cells in the dentate gyrus of mice selectively bred for their sensitivity to acute ethanol exposure (long-sleep, LS and short-sleep, SS) was assessed in two experiments. In addition, the effect of chronic ethanol on the density of dentate granule ce...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90369-1
更新日期:1988-09-20 00:00:00
abstract::There is a strong link between cognitive impairment and depression, but up to date it is not clear whether cognitive impairment is 'cause' or 'consequence' of depression. Therefore, we here examined the effect of cognitive impairment induced by permanent occlusion of common carotid arteries, a model known as two-vesse...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.09.056
更新日期:2015-01-30 00:00:00
abstract::The understanding of sentences involves not only the retrieval of the meaning of single words, but the identification of the relation between a verb and its arguments. The way the brain manages to process word meaning and syntactic relations during language comprehension on-line still is a matter of debate. Here we re...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2006.08.038
更新日期:2007-05-18 00:00:00
abstract::Many parts of the brainstem are known to be innervated by the cholinergic neurons of the pontomesencephalic tegmentum, but other possible sources of this innervation have rarely been considered. We sought to examine whether other cells in the brainstem were responsible for this cholinergic input using axonal tract tra...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90185-6
更新日期:1994-02-04 00:00:00
abstract::Single cell suspensions of early postnatal mouse cerebellum adhere to substrate-bound culture supernatants of the teratocarcinoma cell line PF-HR9 and can be inhibited to adhere by antibodies to the neural cell adhesion molecules L1 and N-CAM. Adhesion can also be inhibited by the glycosaminoglycans heparin and hepara...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(88)90101-0
更新日期:1988-10-01 00:00:00
abstract::Hypothalamic nuclei close to the third ventricle (VIII) represent key structures in avian osmoregulation concerned with the control of salt gland activity and release of the antidiuretic hormone [Arg8]vasotocin (AVT). Nitric oxide (NO) acting as a paracrine transmitter in the hypothalamus has been shown to contribute ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01205-6
更新日期:1999-04-17 00:00:00
abstract::Previous studies suggest that brainstem catecholamine (CA) fibers which mediate amphetamine (AMPH)-induced anorexia ascend through the midlateral medical forebrain bundle and perifornical region and terminate in the perifornical hypothalamic region (PFH) at the level of the hypothalamic ventromedial nucleus. Through s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90085-4
更新日期:1984-10-08 00:00:00
abstract::When nomifensine is employed to inhibit neuronal uptake, exposure to dopamine (DA) (0.1-0.3 microM) or apomorphine (0.01-0.1 microM) inhibited, in a concentration-dependent manner, the electrically evoked release of [3H]dopamine from slices of the rabbit caudate nucleus. Apomorphine inhibited transmitter release indep...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91605-1
更新日期:1985-06-24 00:00:00
abstract::Growth hormone (GH) suppresses its own secretion by stimulating somatostatin (SRIF) release. Thus, the possible regulation of GH-releasing factor (GRF) and SRIF release and SRIF messenger ribonucleic acid (mRNA) by GH was studied in the hypothalamus of male rats in vitro. The median eminences (ME's) were incubated in ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90014-e
更新日期:1993-09-24 00:00:00
abstract::We have identified an inhibitory neuron (RPL4) in the right pleural ganglion of Aplysia, which produced hyperpolarization of the sensory and motor neurons involved in the tail withdrawal reflex. Activation of RPL4 significantly reduced the amplitude of excitatory postsynaptic potentials produced in tail motor neurons ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90548-n
更新日期:1992-04-10 00:00:00
abstract::The concentrations of GABA, glutamate, aspartate, glycine, taurine, glutamine, asparagine and alanine were determined in the CSF of 10 Senegalese baboons (Papio papio) following initial ketamine anaesthesia and subsequent administration (4 h later) of different compounds known to alter either inhibitory or excitatory ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90370-b
更新日期:1991-01-04 00:00:00
abstract::The effects of stimulating the reticular formation were studied during fictive locomotion in lampreys (Ichthyomyzon unicuspis). The in vitro isolated preparation of the brainstem and spinal cord was used and fictive locomotion was induced by bath application of N-methyl-D-aspartate (NMDA; 50-100 microM). During differ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00151-0
更新日期:1997-04-11 00:00:00
abstract::The number of hypocretin-containing neurons is markedly decreased in most patients with the sleep disorder narcolepsy. It is presently not known why the loss of hypocretin neurons occurs in these patients. In the present study, we tested the role of inflammation in the degeneration of hypocretin neurons. The proinflam...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.06.016
更新日期:2004-09-03 00:00:00
abstract::During aging, estrogen production and circulating levels of estrogen are markedly decreased in females. Although several differences exist in the process of reproductive aging between women and female rats, the results of many studies suggest that the female rat, especially the middle-aged or aged ovariectomized femal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.11.010
更新日期:2014-01-16 00:00:00
abstract::Intracellular recordings were obtained from CA1 pyramidal neurons in obliquely cut in vitro hippocampal slices. Recurrent IPSPs were elicited by antidromic stimulation of alvear fibers. The mechanisms by which IPSPs depress pyramidal cell excitability were investigated. Recurrent IPSPs could be reversed in sign by sma...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)91068-9
更新日期:1980-03-10 00:00:00
abstract::The distribution of nitric oxide synthase (NOS)-, choline acetyltransferase (ChAT)-, and vasoactive intestinal polypeptide (VIP)-immunoreactivities, and nicotinamide adenine dinucleotide phosphate diaphorase (NADPHd)-reactivities in the sphenopalatine ganglia (SPG), and perivascular nerves in middle cerebral arteries ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00548-4
更新日期:1998-08-10 00:00:00