Abstract:
:We studied the effects of axotomy or neurotoxin on the survival of substantia nigra pars compacta (SNpc) neurons in two strains of mice, FVB/N or C57BL/6. Fluoro gold (FG) was injected into both striata of the mice to retrogradely label the nigrostriatal neuronal population. Ten days later, these neurons were axotomized in the medial forebrain bundle (MFB) unilaterally or N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was administered intraperitonealy for 2 days to produce bilateral degeneration. MFB transection or MPTP administration produced a progressive loss of FG-labeled and tyrosine hydroxylase immunolabeled (TH+) neurons in both strains. Relative to control, 72% of SNpc neurons died 4 weeks after axotomy in C57BL/6 mice and 50% died after axotomy in FVB/N mice. MPTP resulted in death of 80% of SNpc neurons in C57BL/6 mice but only 40% in the FVB strain 4 weeks after MPTP administration. In this more sensitive strain, MPTP cell death was associated with positive staining for terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) and nuclear condensation. In contrast, no TUNEL staining was detected in SNpc after MPTP in FVB/N mice. Further, while similar kinetics and extent of cell death accompanied axotomy, axotomy-induced cell death was TUNEL negative in both FVB/N and C57BL/6 mice. Double staining for TUNEL and microtubule associated protein 2 confirmed that the majority of the TUNEL positive cells were neurons. These data indicate that genetic factors and the type of lesion play an important role in determining death of dopaminergic neurons after injury.
journal_name
Brain Resjournal_title
Brain researchauthors
Liu L,Hsu SS,Kalia SK,Lozano AMdoi
10.1016/j.brainres.2003.09.066subject
Has Abstractpub_date
2003-12-24 00:00:00pages
243-52issue
2eissn
0006-8993issn
1872-6240pii
S0006899303037958journal_volume
994pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Parvalbumin (PV) and calbindin (CB) immunoreactivities were assessed in nucleus robustus archistriatalis (RA) of male and female zebra finches, together with retrograde labelling of RA neurons. The results of double and triple labelling experiments suggested that, in males, moderately and faintly PV-positive neurons w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02938-9
更新日期:2001-11-02 00:00:00
abstract::Power spectral analysis of the electroencephalogram (EEG) is a non-invasive method to examine infant brain maturation. Preterm fetal growth restricted (p-FGR) neonates display an altered EEG power spectrum compared to appropriate-for-gestational-age (AGA) peers, suggesting delayed brain maturation. Longitudinal studie...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.10.010
更新日期:2018-01-01 00:00:00
abstract::The opioid peptides Leu-enkephalin, Met-enkephalin and D-Ala2-Met-enkephalinamide were injected at various concentrations into the neocortex and hippocampus of rats to examine their effects on EEG activity and DC potentials. All three compounds were found to elicit spreading depression (SD) in both structures. Higher ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90897-0
更新日期:1981-04-06 00:00:00
abstract::In pentobarbitone-anesthetized cats, the spike sequences of dorsal horn neurons were recorded in response to random stimulation of branches of the suralis nerve. Combined frequency- and time-domain analysis was performed on the stimulus and spike trains. Coherence function estimates computed by spectral analysis were ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90598-7
更新日期:1988-10-11 00:00:00
abstract::Rhyme processing is reflected in the electrophysiological signals of the brain as a negative deflection for non-rhyming as compared to rhyming stimuli around 450 ms after stimulus onset. Studies have shown that this N450 component is not solely sensitive to rhyme but also responds to other types of phonological overla...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.09.018
更新日期:2012-11-05 00:00:00
abstract::Our recent results showed that angiotensin II or III (AII, AIII) microinjected into the zona incerta (ZI) significantly increased water intake. The most effective doses of AII and AIII were also defined. The two neuropeptides had their effects differently on drinking via different receptors. AII bound to AT(1) that wa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.01.002
更新日期:2004-03-26 00:00:00
abstract::Immunohistochemical studies with an antiserum raised against tyrosine hydroxylase have allowed us to demonstrate a dense dopaminergic innervation of the globus pallidus in the squirrel monkey. This innervation derived mostly from two fascicles that detached themselves from the major ascending dopaminergic bundle arisi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90896-1
更新日期:1987-11-24 00:00:00
abstract::Single unit extracellular recordings were obtained from cat lumbar spinal cord dorsal horn neurons activated by cutaneous inputs. The effect of electrical conditioning stimuli applied to the red nucleus (RN) was predominantly that of inhibition although in some cases excitation was seen. All the neurons that projected...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91413-6
更新日期:1984-10-08 00:00:00
abstract::The feedback effect of activity of area 21a on orientation maps of areas 17 and 18 was investigated in cats using intrinsic signal optical imaging. A spatial frequency-dependent decrease in response amplitude of orientation maps to grating stimuli was observed in areas 17 and 18 when area 21a was inactivated by local ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.11.024
更新日期:2004-02-20 00:00:00
abstract::By means of an immunohistochemical technique, we examined the neuronal induction of 72-kDa heat shock protein (HSP72) in response to methamphetamine-induced hyperthermia in the mouse hippocampus. Strong HSP72 immunoreactivity (ir) was found in the neurons of hippocampus proper, particularly in the CA1/2 and medical CA...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90602-j
更新日期:1993-10-29 00:00:00
abstract::Cannabinoids are promising therapies to support neurogenesis and decelerate disease progression in neuroinflammatory and degenerative disorders. Whether neuroprotective effects of cannabinoids are sustainable during persistent viral infection of the CNS is not known. Using a rodent model of chronic viral encephalitis ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.08.032
更新日期:2013-11-06 00:00:00
abstract::The present study provides evidence for the presence of an endogenous ligand for the phencyclidine (PCP) receptor of mammalian brain. Partially purified bovine hippocampal extracts potently and dose dependently inhibit binding to PCP receptors of [3H]N-(1-[2-thienyl]-cyclohexyl)piperidine (TCP), a highly potent and sp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91499-5
更新日期:1987-07-21 00:00:00
abstract::We have developed a RNA-RNA solution hybridization assay to quantitate the mRNA coding for prodynorphin precursor. This assay is extremely sensitive and highly specific. Using this assay we have measured the prodynorphin mRNA in various brain regions and reproductive tissues of rat. When we compared the distribution o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(87)80011-2
更新日期:1987-07-01 00:00:00
abstract::The effect of valproic acid (VPA) on synaptic transmission was investigated at the frog neuromuscular junction using electrophysiological methods. The drug caused a dose-dependent decrease in the quantal content of the endplate potential (EPP) and a significant reduction in the input resistance of the postjunctional m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90393-7
更新日期:1984-07-23 00:00:00
abstract::This study was designed to evaluate the functional significance of angiotensin II (Ang II) receptors identified by previous receptor autoradiography studies to be located presynaptically on terminals of dopaminergic neurones projecting to the striatum. Microdialysis was performed in the striatum of conscious freely mo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90902-y
更新日期:1993-06-11 00:00:00
abstract::Nerve injury was produced by application of dry ice to the common peroneal nerve. After 20 weeks, muscle-spindle primary endings responded normally to stretch and the spindles were found to have a fully functional fusimotor innervation. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90372-5
更新日期:1985-11-25 00:00:00
abstract:BACKGROUND:Cerebral ischemia is a major leading cause of death and at the first place cause of disability all over the world. There are a lot of drugs that are in experimental stage for treatment of stroke. Among them are calcium channel blockers (CCBs) that have, in animal models, different effectiveness in healing of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.07.038
更新日期:2007-10-24 00:00:00
abstract::The parabrachial nucleus consists of several subnuclei which contains autonomic, gustatory, visceral sensory, nociceptive, and respiratory related neurons. We have investigated the direct projections from the rat parabrachial region, including the K olliker-Fuse nucleus, to the pharyngeal motoneurons with an anterogra...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01127-5
更新日期:1999-01-23 00:00:00
abstract::Infection and inflammation leading to injury or death of pre-oligodendrocytes (preOLs) is one of the principal initiating mechanisms in the pathogenesis of preterm periventricular leukomalacia (PVL). The present study explores the possible protective effect of curcumin against the toxicity of lipopolysaccharide (LPS)-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.04.014
更新日期:2010-06-21 00:00:00
abstract::Rats were administered haloperidol (0.5 mg/kg/day) for 21 days. Twenty percent of locus coeruleus (LC) neurons recorded were not spontaneously active, while no such neuron was observed in control animals. A further 22% of neurons (spontaneously active) had rates greater than 2 standard deviations from the mean of LC c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90346-4
更新日期:1985-01-28 00:00:00
abstract::We have developed a cell culture system for the rat suprachiasmatic nucleus, in which a clear circadian oscillation of vasopressin release was observed. Using this culture system, the effect of anisomycin, an inhibitor of protein synthesis, on the circadian rhythm was studied. A phase-delay of more than 15 h could be ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00414-l
更新日期:1995-07-03 00:00:00
abstract::Whole-cell voltage-clamp techniques were used to study the comparative effects of delta-9-tetrahydrocannabinol (THC) and its principal metabolite, 11-hydroxy-delta-9-tetrahydrocannabinol (11-OH-THC), on the voltage-gated sodium current in neuroblastoma cells. The parent compound markedly depressed the inward sodium cu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91239-w
更新日期:1991-09-27 00:00:00
abstract::Classical conditioning the rabbit nictitating membrane involves changes in synaptic and intrinsic membrane properties of cerebellar Purkinje cell dendrites, and a 4-aminopyridine (4-AP)-sensitive potassium channel underlies these membrane properties. We characterized I(A) currents in adult, rabbit Purkinje cells to de...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.04.048
更新日期:2006-06-22 00:00:00
abstract::38 primary afferents originating from de-efferented cat tibialis anterior muscle spindles were investigated. Ramp-and-hold stretches of the host muscle were performed with a varying amount of muscle pre-stretch while recording the primary afferent discharges. From the discharge responses an interspike interval functio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91650-h
更新日期:1993-05-28 00:00:00
abstract::The mammalian circadian clock in the suprachiasmatic nuclei (SCN) can be phase-shifted in vitro by the serotonin agonist quipazine. Here we show that quipazine resets the SCN clock in the presence of tetrodotoxin or 10 mM Mg2+, treatments that block Na+ action potentials and Ca2+ channels, respectively. These results ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90784-7
更新日期:1992-02-28 00:00:00
abstract::Previous studies have shown that within 24 h after ischemic insult, gerbils exhibit an increase in locomotor activity. Because activity gradually diminishes to normal levels with repeated testing, it has been argued that this behavior represents a reversible or transient effect of ischemia. The present study challenge...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91081-3
更新日期:1993-10-22 00:00:00
abstract::The distribution of the regulatory (RII beta) subunits of type II cAMP-dependent protein kinase in cortical and subcortical areas was examined in human control and Alzheimer's disease (AD) brains. Four monoclonal antibodies generated against bovine brain RII, which cross-reacted with human brain RII beta, detected RII...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90230-7
更新日期:1992-04-24 00:00:00
abstract::Previous studies using the technique of microinjection into brain nuclei indicated that the periaqueductal gray (PAG), nucleus accumbens, habenula and amygdala play an essential role in pain modulation and that these nuclei possibly act through a 'mesolimbic neural loop' to exert an analgesic effect, in which Met-enke...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91685-t
更新日期:1991-12-06 00:00:00
abstract::Ontogeny of somatostatin (SRIF) neuron system of the rat cerebellum was investigated by means of the indirect immunofluorescent method. In addition, several operations were performed to provide the evidence of understanding the cerebellar SRIF innervation. SRIF-positive structures appeared in the primordium of the cer...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(82)90051-7
更新日期:1982-04-01 00:00:00
abstract::The fine structure of reaggregating cultures of cells from 6- to 7-day-old mouse cerebellum was studied at intervals between 3 and 21 days in vitro (DIV). The resulting aggregates consisted mainly of small neurons (granule, stellate and basket cells), neuroglial cells and their processes. Large neurons were rarely pre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(84)90067-1
更新日期:1984-09-01 00:00:00