Abstract：
:Previous studies using the technique of microinjection into brain nuclei indicated that the periaqueductal gray (PAG), nucleus accumbens, habenula and amygdala play an essential role in pain modulation and that these nuclei possibly act through a 'mesolimbic neural loop' to exert an analgesic effect, in which Met-enkephalin (MEK) and beta-endorphin (beta-EP) have been implicated as the two major opioid peptides involved in antinociception. In the present study performed in rabbits, intracranial microinjection was supplemented with push-pull perfusion and radioimmunoassay to determine whether the release of enkephalins (ENK) and beta-EP was increased in these nuclei when the putative neural circuit was activated by morphine administered into one of the nuclei. The results showed: (1) microinjection of morphine into the PAG increased the release of ENK and beta-EP in the N. accumbens, and vice versa; (2) microinjection of morphine into the N. accumbens increased the release of ENK and beta-EP in the amygdala, and vice versa; (3) morphine microinjected into the PAG caused an increase in the release of ENK and beta-EP in the amygdala and vice versa, although the release of ENK in PAG was statistically not significant. These results indicate that PAG, N. accumbens and amygdala are connected in a network served by a positive feedback circuitry.
journal_name
Brain Resjournal_title
Brain researchauthors
Ma QP,Han JSdoi
10.1016/0006-8993(91)91685-tsubject
Has Abstractpub_date
1991-12-06 00:00:00pages
95-102issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(91)91685-Tjournal_volume
566pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Cerebral cells of origin for the corticospinal (CST), corticopontine (CP), corticorubral (CR) and corticostriatal (CS) fibers in the rat were identified following the simultaneous retrograde transport of propidium iodide (PI), fast blue (FB), fluorogold (FG) and diamidino yellow (DY). PI was injected into the contrala...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91629-s
更新日期：1992-07-24 00:00:00
abstract：:The existence of spinal neuron collaterals projecting to the intralaminar thalamic nuclei (ILN) and the periaqueductal gray (PAG) was determined in the rat using double-labeling, fluorescent, retrograde axoplasmic transport techniques. Distinctively double-labeled neurons, although not numerous, were found in the enti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90731-6
更新日期：1986-02-12 00:00:00
abstract：:We have investigated, in 9 normal subjects, the time course of amplitude changes in the automatic long latency stretch reflex of wrist flexors during the preparatory period as a function of the precued direction of hand movement. Subjects maintained right hand position against a weak force and learned to compensate pr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91172-1
更新日期：1983-11-28 00:00:00
abstract：:Insulin has emerged as an important neuropeptide. Central actions of insulin appear to oppose those in the periphery. Insulin is transported across the blood-brain barrier (BBB) by a saturable transport system. The permeability of the BBB to insulin is altered by various events, but no studies exist that have examined...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03247-9
更新日期：2001-03-30 00:00:00
abstract：:The uptake and efflux of 36Cl in the lateral ventricle choroid plexus of 1-7-week-old rats were measured to determine if Cl transport changed with age and if such transport responded to inhibitors of CSF secretion and ion transport. The steady-state (30 min) Cl uptakes were 148 +/- 9.4 nmol.mg-1 dry weight at 1 week a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90076-y
更新日期：1993-10-08 00:00:00
abstract：:The activity of choline kinase (CK) was examined in the rat superior cervical ganglion (SCG) during development and following postganglionic axotomy. The highest specific enzyme activity (nmol phosphorylcholine/mg protein/h) 52 +/- 8, is observed 5 d before birth, then it rapidly decreases by about 50%, reaching at th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91236-1
更新日期：1981-09-14 00:00:00
abstract：:The study investigated the effect of aminoguanidine (AG) on inducible nitric oxide synthase (iNOS), aquaporin-4 (AQP4), malondialdehyde (MDA) and glutathione (GSH) levels in surgical brain injury (SBI) in rats. AG (75, 150 and 300 mg/kg, i.p.) was administered immediately following surgical resection. Using an SBI mod...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.05.041
更新日期：2009-07-28 00:00:00
abstract：:Motor behavior not seen in newborn cats can be revealed by spinal transection and is therefore normally suppressed. Motor performance of these spinal kittens after reaching adulthood surpasses that of chronic adult-operated spinal cats but the latter display a significant improvement when GABAergic inhibition is block...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90879-0
更新日期：1985-11-04 00:00:00
abstract：:We have used magnetic resonance imaging (MRI) of the living rat brain to longitudinally analyze the ontogenesis of an ibotenic acid lesion targeted at the piriform cortex. The MRI data were systematically compared with data obtained from a battery of histopathological techniques, including Nissl stain, hematoxylin sta...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00058-3
更新日期：1996-04-29 00:00:00
abstract：:Thermoregulatory (brown adipose tissue temperature) experiments were conducted in age-matched anesthetized, male Sprague-Dawley and Long Evans rats kept at 37 degrees C given unilateral electrical stimulation of the ventromedial hypothalamic nucleus or the lateral preoptic area or after intravenous infusion of norepin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90422-6
更新日期：1992-03-13 00:00:00
abstract：:Fasting induced a reduction in neuronal nitric oxide synthase (nNOS) mRNA in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) of rats. The effect of intracerebroventricular (i.c.v.) administration of leptin on the nNOS mRNA level in the PVN and SON of fasting rats was studied by in situ hybridization his...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02065-x
更新日期：1999-11-06 00:00:00
abstract：:The present study investigated whether the effects of central cholinergic stimulation on thermoregulation during exercise are modulated by arterial baroreceptors. Wistar rats were submitted to sinoaortic denervation (SAD) or sham denervation (SHAM) and then fitted with a chronic guide cannula into the lateral cerebral...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.09.110
更新日期：2010-12-17 00:00:00
abstract：:The default mode network (DMN) is characterised by coherent very low frequency (VLF) neural oscillations in the resting brain. The attenuation of this activity has been demonstrated following the transition from rest to performance of a broad range of cognitive goal-directed tasks. Whether the activity of resting stat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.05.043
更新日期：2013-08-02 00:00:00
abstract：:The subfornical organ of the brain has a role in the regulation of fluid balance in higher animals. In this study the effects of salt loading and water deprivation on specific proteins in this organ were investigated. For 4 days, 3 groups of rats were given an appropriate fluid diet (control, 2% NaCl and water deprive...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91463-0
更新日期：1986-04-30 00:00:00
abstract：:Transependymal absorption of cerebrospinal fluid (CSF) in hydrocephalus is suggested by periventricular edema, but the necessary bulk flow of interstitial fluid (ISF) has not been found. We performed ventriculocisternal perfusions in adult cats using CSF with the extracellular marker [3H]sucrose. CSF pressure was main...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90616-3
更新日期：1982-01-28 00:00:00
abstract：:A transplantable mouse testicular teratoma (OTT 6050) which displays a spectrum of neuroepithelial differentiation was evaluated biochemically for concentrations of cyclic AMP (cAMP), serotonin (5-HT), and enzymes involved in the metabolism of the biogenic amines and acetylcholine. These values were compared between t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90268-7
更新日期：1976-01-16 00:00:00
abstract：:Functional magnetic resonance imaging studies on episodic memory (EM) retrieval have used a variety of paradigms/contrasts to yield many diverse findings, which raises the need for an integrative multifactorial view. To address this need, I begin by proposing a fourstage, quasi-sequential model of network activity dur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147049
更新日期：2020-11-15 00:00:00
abstract：:This study investigated the effects of antidromically conducted nerve impulses on the transmission of orthodromic volleys in primary afferents of the hindlimb in decerebrated paralyzed cats. Two protocols were used: (A) Single skin and muscle afferents (N=20) isolated from the distal part of cut dorsal rootlets (L7-S1...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01236-6
更新日期：1999-04-17 00:00:00
abstract：:We investigated the effects of inverting facial contour (hair and chin) and features (eyes, nose and mouth) on processing for static and dynamic face perception using magnetoencephalography (MEG). We used apparent motion, in which the first stimulus (S1) was replaced by a second stimulus (S2) with no interstimulus int...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.01.091
更新日期：2011-04-06 00:00:00
abstract：:Serial ion-exchange and high-performance liquid chromatography separations were employed for the tissue extraction and purification of kynurenic acid (KYNA). Subsequently, the compound isolated from postmortem human brain tissue was unequivocally identified as KYNA by nuclear magnetic resonance and mass spectrometric ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90815-3
更新日期：1988-06-28 00:00:00
abstract：:Hydroxyindole-O-methyltransferase (HIOMT) catalyses the last step of all the 5-methoxyindoles synthesized in the pineal gland. The synthetic activity of this neuroendocrine structure is driven not only by noradrenaline but also by various neuropeptides. Recently we have established (1) that one of these neuropeptides,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00556-3
更新日期：1998-08-10 00:00:00
abstract：:Horseradish peroxidase (HRP) was used as a retrograde tracer to identify the distribution pattern of labeled cells in the inferior olivary nucleus (IO) of Tupaia. Crystallized HRP was implanted into dorsal (DPML) and ventral (VPML) divisions of the paramedian lobule (PML) and, following appropriate survival times, the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90433-5
更新日期：1984-07-09 00:00:00
abstract：:The responses of single alpha motoneurons to various "natural' stimuli were recorded from dissected ventral root filaments in lightly anesthetized control and recently decerebellate cats. The identity of the motoneurons was established by recording the unitary responses to orthodromic stimulation of nerves innervating...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90208-5
更新日期：1975-09-12 00:00:00
abstract：OBJECTIVE:There is an increasing interest concerning the contribution of astrocytes to the intrinsic bioremediation of ischemic brain injury. The aim of this work was to disclose the effects and mechanism of dexmedetomidine (DEX) on the apoptosis of astrocytes under oxygen glucose deprivation (OGD) condition. METHODS:...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147141
更新日期：2021-01-01 00:00:00
abstract：:Opiate regulation of the nuclear proto-oncogene c-fos was studied in the locus coeruleus (LC) and other regions of rat brain by immunoblotting, northern blotting, and in situ hybridization procedures. Precipitation of opiate withdrawal in rats, which is known to increase LC firing rates 4-fold, led to a two- to three-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90872-9
更新日期：1990-08-20 00:00:00
abstract：:The effect of L-AP4, a group III mGluR agonist, on sensory synaptic transmission in the lamprey spinal cord has been analyzed. Paired recordings were made between cutaneous mechanosensory neurons (dorsal cells) and postsynaptic spinobulbar giant interneurons. L-AP4 reduced the monosynaptic dorsal cell-evoked EPSP, but...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02462-9
更新日期：2002-05-24 00:00:00
abstract：:Distribution of the monocarboxylate transporter MCT1 has been investigated in the cortex of normal adult human brain. Similarly to the glucose transporter GLUT1 55 kDa isoform, MCT1 was found to be strongly expressed on blood vessels in all cortical layers. In addition, laminar analysis revealed intense MCT1 expressio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.11.064
更新日期：2006-01-27 00:00:00
abstract：:Co-activation of group I metabotropic glutamate (mGlu) receptors and adenosine receptors resulted in an augmented cyclic AMP response in primary cultures of rat striatal neurones. L-glutamate and the selective group I agonist, (S)-dihydroxyphenylglycine (S-DHPG) evoked concentration-dependent potentiations of cyclic A...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00094-8
更新日期：1998-04-27 00:00:00
abstract：:Repeated odorant or electrical stimulation of the frog olfactory nerve leads to long-lasting reduction of excitability of the receptor neurons. In the turtle olfactory nerve electrical stimulation causes an increase in extracellular potassium concentration due to the efflux of potassium from active axons. Elevated pot...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90340-h
更新日期：1990-12-24 00:00:00
abstract：:Treatment with thyrotropin-releasing hormone (TRH) significantly improved survival following induction of fatal systemic anaphylaxis in mice. The protective effect was mediated centrally since survival was increased by intracerebroventricular (i.c.v.) administration of TRH at doses which had no effect when given syste...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91421-5
更新日期：1984-04-30 00:00:00
