Abstract：
:We have used magnetic resonance imaging (MRI) of the living rat brain to longitudinally analyze the ontogenesis of an ibotenic acid lesion targeted at the piriform cortex. The MRI data were systematically compared with data obtained from a battery of histopathological techniques, including Nissl stain, hematoxylin stain, and a stain for cytochrome oxidase activity. Two days after the lesioning, widespread and heterogeneous damage was detected in, around and distant from the toxin-targeted area. Some damage apparently diminished within approximately 10 days, whereas other damage remained throughout the length of this study (60 days). We found that the small-animal MRI technology used by us is useful in determining the initial, transient impact of surgery and neurotoxic lesioning, and in delineating the gross effects of the lesion over time. This is particularly useful for early elimination of animals from the protocol of physiological and behavioral experiments in which the lesion exceeds the target area. Our data also indicate that, in order to avoid confounding effects of transient post-lesioning phenomena, behavioral and physiological tests should be carried out in neurotoxically lesioned animals > 2 weeks after infliction of the lesion.
journal_name
Brain Resjournal_title
Brain researchauthors
Ben-Horin N,Hazvi S,Bendel P,Schul Rdoi
10.1016/0006-8993(96)00058-3subject
Has Abstractpub_date
1996-04-29 00:00:00pages
97-104issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(96)00058-3journal_volume
718pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Our previous studies demonstrated that Austrolebias charrua annual fish is an excellent model to study adult brain cell proliferation and neurogenesis due to the presence of active and fast neurogenesis in several regions during its short lifespan. Our main goal was to identify and localize the cells that compose the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.08.003
更新日期：2017-10-15 00:00:00
abstract：:This study investigated the effects of REM (rapid eye movement) sleep deprivation (RSD) on the activity of central cholinergic receptors and passive avoidance retention in rats treated neonatally with clomipramine. Male rat pups treated with clomipramine (15 mg/kg, s.c.) twice daily from postnatal day 5 to 21 were sub...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02248-4
更新日期：2000-06-09 00:00:00
abstract：:The developmental and age-related changes of the dopamine transporter (DAT), and the dopamine D1 and D2 receptor (D1R and D2R) subtypes were investigated in basal ganglia (BG) of human brain. DAT immunostaining was mainly observed in the neuropil, neurons, and glia of the striatum. The DAT-positive neuropil was detect...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01933-2
更新日期：1999-10-02 00:00:00
abstract：:In this study we examined blood pressure and heart rate responses to intrathecal administration of a synthetic NK1-receptor agonist, H2N-(CH2)4-CO-Phe-Phe-Pro-NmeLeu-Met-NH2 (GR 73,632), in spontaneously hypertensive rats (SHR) and their progenitor strain, the Wistar-Kyoto rat (WKY). Sodium pentobarbitone anaesthetise...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01107-x
更新日期：1999-01-02 00:00:00
abstract：:We elucidated how Alzheimer-type pathologies of amyloid beta-protein (Abeta) and tau spatiotemporally emerge in brains of nontransgenic nonhuman primate, cynomolgus monkey, in the present study. To examine the accumulation of deposited Abeta, phosphorylated tau accumulation, intracellular tau accumulation, and neurofi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.12.005
更新日期：2010-02-22 00:00:00
abstract：:Many parts of the brainstem are known to be innervated by the cholinergic neurons of the pontomesencephalic tegmentum, but other possible sources of this innervation have rarely been considered. We sought to examine whether other cells in the brainstem were responsible for this cholinergic input using axonal tract tra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90185-6
更新日期：1994-02-04 00:00:00
abstract：:Alterations in neurotrophic signaling pathways may contribute to the changes in the mesolimbic dopamine system induced by chronic morphine exposure. In a rat model of morphine dependence, we previously identified increased levels of phospholipase C gamma-1 (PLCgamma1) immunoreactivity specifically within the ventral t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.04.059
更新日期：2007-07-02 00:00:00
abstract：:Cyclic nucleotide phosphodiesterase-4 (PDE4) is a component of signaling pathways involved in the mediation of antidepressant activity. Of the four PDE4 subtypes, PDE4D appears to be of particular importance, given the finding that PDE4D-deficient mice exhibit an antidepressant-like behavioral phenotype. In mouse hipp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.04.032
更新日期：2006-06-22 00:00:00
abstract：:Generalized barrel-rolling convulsions and focal hypermetabolic responses in the cerebellar cortex of conscious rats to lateral ventricular injection of the neuropeptide, endothelin-1 (ET; 9 pmol), were diminished or eliminated by i.c.v. pretreatment with the glutamatergic NMDA receptor antagonist, MK-801 (44 nmol). U...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91334-x
更新日期：1994-06-06 00:00:00
abstract：:The kindling process represents a progressively augmenting electrical and behavioral response to brain stimulation, that has been proposed as a model for the development of epileptogenesis. The first experiment examined the effects of hypophysectomy on the kindling process. The effects of hypophysectomy were found to ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)91032-1
更新日期：1979-06-22 00:00:00
abstract：:The time-course of intracellular glutathione (GSH) values after incubation with L-buthionine-(S,R)-sulfoximine (BSO), a selective inhibitor of gamma-glutamylcysteine synthetase, showed that glutathione turns over with a half-life of 5 h. Intracellular GSH was assayed by flow cytometry using three different methods. As...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91264-s
更新日期：1993-08-06 00:00:00
abstract：:The organization of the wing component of the dorsal column-medial lemniscal pathway, and somatosensory projections from the thalamus to the Wulst, are described for an oscine member of the major group of birds, the Passeriformes. Wing primary afferents terminate throughout the cervical spinal cord, but between the br...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00253-9
更新日期：1997-06-06 00:00:00
abstract：:The aim of this study was to investigate the degree of functional and anatomical overlap between two major neuronal subpopulations in the rostral ventrolateral medulla: pre-sympathetic (sympathoexcitatory) neurons, and expiratory neurons of the Bötzinger complex. Extracellular recordings were made with dye-filled micr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00814-7
更新日期：1995-11-13 00:00:00
abstract：:The ability to adapt a variety of motor acts to compensate for persistent natural or artificially induced errors in movement accuracy requires the cerebellum. For adaptation of the rapid shifts in the direction of gaze called saccades, the oculomotor vermis (OMV) of the cerebellum must be intact. We disrupted the neur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.05.027
更新日期：2011-07-15 00:00:00
abstract：:Calcitonin gene-related peptide (CGRP) and substance P (SP) immunoreactivity was examined in neurons of the monkey trigeminal ganglion. Moreover, CGRP- and SP-positive varicose nerve fibers were found, occasionally forming pericellular arborizations around trigeminal somata, which, at light microscopic level, suggeste...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91337-r
更新日期：1993-12-03 00:00:00
abstract：:Immunohistochemical studies have suggested that corticotropin-releasing factor (CRF) was a transmitter of the olivocerebellar projection. We used in situ hybridization histochemistry with a 35S-labeled oligodeoxyribonucleotide probe for CRF mRNA to show that inferior olivary neurons of rats, baboons, and humans synthe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(86)90010-0
更新日期：1986-11-01 00:00:00
abstract：:The extracellular lactate concentration and blood flow in the cerebral cortex of urethane-anesthetized, paralyzed and artificially ventilated rats were monitored continuously and simultaneously using an enzyme electrode and a laser Doppler flowmeter (LDF), respectively, during chemical stimulation of the nucleus tract...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01428-x
更新日期：1997-05-30 00:00:00
abstract：:Weaver mutant mice alternated above chance levels but less often than normal mice in a 2-trial spontaneous alternation test. When the inter-trial (or retention) interval was manipulated, the weaver mutants alternated above chance levels only at the shortest (15 s) but not at the longest (4 or 5 min) intervals, contrar...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91265-5
更新日期：1986-11-19 00:00:00
abstract：:Cerebrovascular diseases are currently a major global health problem. Considering the limitations of current therapy, the search for new alternatives for the treatment of these diseases is necessary and, in this context, curcumin, a molecule that has neuroprotective properties already described in the literature. A li...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147007
更新日期：2020-11-01 00:00:00
abstract：:The aim of this study was to test the role of the perifornical hypothalamus and adjacent areas in the behavioral and cardiovascular responses to two forms of stress, conditioned fear to context and restraint. Of particular interest was the role of the hypocretin (orexin) containing neurons in these responses. Rats imp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.10.058
更新日期：2007-01-12 00:00:00
abstract：BACKGROUND:An important part of the medical treatment of many cerebrovascular diseases is the occlusion of brain supplying arteries. Until now, the risk of this intervention can only be estimated by invasive diagnostics including the risk of cerebrovascular accidents. METHODS AND RESULTS:As a supporting tool, a comput...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.08.021
更新日期：2006-11-06 00:00:00
abstract：:Apoptosis has been shown to be induced by some pathological stimuli. MPP+ is a neurotoxin and an inducer of parkinsonism. When SH-SY5Y cells, human neuroblastoma cell line, were treated with MPP+, cell death estimated by lactate dehydrogenase (LDH) leakage assay occurred. The cell death was associated with the DNA fra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01120-x
更新日期：1995-12-18 00:00:00
abstract：:The influence of emotion on cognition plays an important role in people's everyday life as well as in psychiatric and neurological disorders. The present study used fMRI to examine the neural correlates of cognitive-emotional interactions and its inter-individual differences. Twenty-one healthy males performed a 0-bac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.03.048
更新日期：2007-06-04 00:00:00
abstract：:Post traumatic stress disorder (PTSD) is characterised by hyperarousal, anxiety and amnesic symptoms. Deficits in explicit memory recall have been causally related to volume reductions of the hippocampus and prefrontal cortex. While stress-related glucocorticoid secretion appears involved in this apparent atrophy, the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03033-6
更新日期：2003-09-05 00:00:00
abstract：:Endogenous gamma-aminobutyric acid (GABA) release from the rat medial preoptic area (MPOA) was measured in an in vitro slice technique with sensitive HPLC analysis. Oestrogen is demonstrated to increase GABA activity in the ovariectomised, oestrogen-primed (OVX-EB) rat prior to the luteinising hormone (LH) surge compa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91295-x
更新日期：1989-05-01 00:00:00
abstract：:Administration of benzodiazepines at appropriate times in the circadian cycle induce phase-shifts in circadian locomotor activity. The possibility that benzodiazepine-induced shifts are mediated at the level of the suprachiasmatic nuclei (SCN), identified as the circadian pacemaker in mammals, was examined electrophys...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90659-j
更新日期：1991-06-21 00:00:00
abstract：:The distribution of inositol 1,4,5-trisphosphate (InsP3) 3-kinase was studied in the adult rat brain, using polyclonal antibodies raised against the purified 50,000-Da rat brain enzyme by immunohistochemistry and Western blot, in addition to enzymatic assay. Immunohistochemically, the enzyme was detected in neurons, w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91622-8
更新日期：1991-01-25 00:00:00
abstract：:This study compared whether activation of muscle ergoreceptor afferents caused by isometric muscle contraction, activation of baroreceptor afferents induced by i.v. infusion of phenylephrine, or baroreceptor afferent inactivation, caused by carotid artery occlusion, elicit similar patterns of c-Fos induction in brains...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02217-9
更新日期：2000-01-10 00:00:00
abstract：:The effects of streptozotocin-induced diabetes mellitus on the activity of discrete regions of the brain were studied with histochemical localization and photodensitometric quantification of the metabolic enzyme, hexokinase. Two weeks after a single injection of streptozotocin (65 mg/kg, i.p.), plasma glucose and osmo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91593-6
更新日期：1990-07-02 00:00:00
abstract：:The neurite promoting factors in the astroglial conditioned medium (As-CM) were characterized by using primary cultures of embryonic rat neocortical neurons. The factors in the As-CM bind to lectins such as wheat germ agglutinin (WGA), suggesting that they contain sugar moieties. When the WGA-bound fractions were appl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91059-p
更新日期：1990-09-10 00:00:00
