The paragigantocellular nucleus of the ventral medulla: a secondary source of cholinergic innervation of rat brainstem nuclei.

Abstract:

:Many parts of the brainstem are known to be innervated by the cholinergic neurons of the pontomesencephalic tegmentum, but other possible sources of this innervation have rarely been considered. We sought to examine whether other cells in the brainstem were responsible for this cholinergic input using axonal tract tracing and choline acetyltransferase (ChAT) immunocytochemistry. The results confirm previous studies on the projections of the neurons of the pontomesencephalic tegmentum but also show that a group of ChAT-positive cells in the paragigantocellular nucleus in the ventral medulla are a source of widespread, albeit less substantial cholinergic projections to several areas of the brainstem.

journal_name

Brain Res

journal_title

Brain research

authors

Sherriff FE,Henderson Z

doi

10.1016/0006-8993(94)90185-6

subject

Has Abstract

pub_date

1994-02-04 00:00:00

pages

119-25

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(94)90185-6

journal_volume

636

pub_type

杂志文章
  • Beta-agkistrodotoxin inhibits large-conductance calcium-activated potassium channels in rat hippocampal CA1 pyramidal neurons.

    abstract::Effect of beta-agkistrodotoxin (beta-AgTx), a presynaptic neurotoxin purified from snake venom, on large-conductance calcium-activated potassium channels (BK(Ca)) was studied in rat hippocampal CA1 pyramidal neurons using inside-out configuration of patch-clamp technique. The results showed that in equimolar K+ (150 m...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)02560-x

    authors: Wu Y,Wang ZF,Shi YL

    更新日期:2002-06-14 00:00:00

  • Glucocorticoid binding sites in human temporal cortex.

    abstract::This work describes the presence of glucocorticoid binding sites in human temporal cortex obtained following partial lobectomy in two epileptic patients. Using [3H]dexamethasone as radioligand and cold cortisol or RU 28362 as competitor we found an apparent Kd of approximately 2.8 nM with a Bmax of approximately 34 fm...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)91444-8

    authors: Sarrieau A,Dussaillant M,Sapolsky RM,Aitken DH,Olivier A,Lal S,Rostène WH,Quirion R,Meaney MJ

    更新日期:1988-02-23 00:00:00

  • gamma-Endorphin and schizophrenia: amino acid composition of gamma-endorphin and nucleotide sequence of gamma-endorphin cDNA from pituitary glands of schizophrenic patients.

    abstract::The possibility has been mentioned that a change in the structure is responsible for the deviant behavioral activity of gamma-endorphin in extracts of postmortem brain and pituitary gland samples of schizophrenic patients. This paper describes the investigation of this possibility by means of: amino acid composition a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)90896-6

    authors: Bovenberg RA,Burbach JP,Wiegant VM,Veeneman GH,van Boom JH,Baas PD,Jansz HS,de Wied D

    更新日期:1986-06-18 00:00:00

  • Enteric origin of bombesin immunoreactive fibres in the rat coeliac-superior mesenteric ganglion.

    abstract::Bombesin-like immunoreactivity occurs in a dense network of nerve fibres in the rat coeliac-superior mesenteric ganglion. No bombesin immunoreactive cell bodies have been observed in this ganglion. An origin outside the ganglion was therefore assumed for the bombesin immunoreactive fibres. Ligation of the mesenteric n...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90981-2

    authors: Schultzberg M,Dalsgaard CJ

    更新日期:1983-06-13 00:00:00

  • Enhanced 5-HT1A receptor expression in forebrain regions of aggressive house mice.

    abstract::The brain 5-HT1A receptor system in male wild house mice selected for high and low offensive aggression was investigated by autoradiographic analysis of in situ hybridization and radioligand binding. In high-aggressive mice, characterized by a short attack latency, the rise in plasma corticosterone concentration durin...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(96)00723-8

    authors: Korte SM,Meijer OC,de Kloet ER,Buwalda B,Keijser J,Sluyter F,van Oortmerssen G,Bohus B

    更新日期:1996-10-14 00:00:00

  • Acute low doses of melatonin restore full sexual activity in impotent male rats.

    abstract::Evidence exists that repeated injections of melatonin in rather large doses inhibit sexual performance in male rats. In contrast, systemic injection of small doses of this hormone stimulates sexual activity of normal male rats. In these experiments, systemic acute administration of melatonin in small doses (10-100 mic...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)02715-3

    authors: Drago F,Busa' L

    更新日期:2000-09-29 00:00:00

  • Dorsal and ventral hippocampal cholinergic systems modulate anxiety in the plus-maze and shock-probe tests.

    abstract::There is emerging evidence that increased acetylcholine levels in brain reduce anxiety. More specifically there is evidence that some of these anxiolytic effects of acetylcholine are modulated by the hippocampus. In the present study we examined the roles of the cholinergic systems in the dorsal and ventral hippocampu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)02965-7

    authors: Degroot A,Treit D

    更新日期:2002-09-13 00:00:00

  • Spinothalamic projections in the pigeon.

    abstract::The spinothalamic projection in an avian species, the pigeon, was studied both with anterograde and retrograde means. Anterograde transport of wheatgerm agglutinin conjugated horseradish peroxidase (WGA-HRP) was used in order to determine the termination of the spinothalamic tract in the thalamus. Application to the l...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)90356-9

    authors: Schneider A,Necker R

    更新日期:1989-04-10 00:00:00

  • Prefrontal cortical dopamine depletion enhances the responsiveness of mesolimbic dopamine neurons to stress.

    abstract::Mild footshock stress results in the metabolic activation of the prefrontal cortical dopamine (DA) innervation, but does not augment DA utilization in mesolimbic areas (such as the nucleus accumbens septi, NAS) or the striatum. However, increases in either the intensity or duration of footshock stress increase DA util...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)91557-w

    authors: Deutch AY,Clark WA,Roth RH

    更新日期:1990-06-25 00:00:00

  • Insulin inhibits pyramidal neurons in hippocampal slices.

    abstract::Recent studies have confirmed the presence of insulin receptors in the rat brain although their function has still not been well defined. The present study explores the possibility that insulin receptors in the brain can alter or contribute to central neurotransmission. Insulin caused a dose-dependent inhibition of hi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)91028-x

    authors: Palovcik RA,Phillips MI,Kappy MS,Raizada MK

    更新日期:1984-08-20 00:00:00

  • Effects of hypothalamic lesions on courtship and copulatory behavior in sexual and unisexual whiptail lizards.

    abstract::Lesions of the anterior hypothalamus-medial preoptic area (AH-MPOA) impair courtship and copulatory behavior in male Cnemidophorus inornatus, a sexually reproducing species of whiptail lizard, and male-like pseudosexual behaviors in C. uniparens, an all-female species. These results suggest that, since C. inornatus is...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)90046-9

    authors: Kingston PA,Crews D

    更新日期:1994-04-18 00:00:00

  • Opioids can enhance and inhibit the electrically evoked release of methionine-enkephalin.

    abstract::The stimulated (40 Hz) release of enkephalin from the myenteric plexus can be modulated by multiple types of opiate receptor. The direction of the modulation is not fixed but is bimodal. Both an inhibition and an enhancement of evoked release is observed depending on the concentration of opioid agonist that is used. E...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)91594-1

    authors: Xu H,Smolens I,Gintzler AR

    更新日期:1989-12-11 00:00:00

  • Learning impairment by minimal cortical injury in a mouse model of Alzheimer's disease.

    abstract::Brain injury accelerates amyloid-β (Aβ) deposits and exacerbates Alzheimer's disease (AD). Accumulation of intracellular soluble Aβ impairs cognition prior to emergence of Aβ plaques. However, it is not known whether brain injury affects learning impairment attributable to intracellular soluble Aβ. We made a small inj...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2016.02.017

    authors: Zou J,Wang M,Uchiumi O,Shui Y,Ishigaki Y,Liu X,Tajima N,Akai T,Iizuka H,Kato N

    更新日期:2016-04-15 00:00:00

  • Ultrastructural evidence of dopaminergic input to enkephalinergic neurons in rat neostriatum.

    abstract::The synaptic relationship between neuronal structures reacting with antibodies to tyrosine hydroxylase (TH) and Leu- or Met-enkephalin (ENK) was studied by the 'mirror technique' in adjacent sections of rat neostriatum. TH-immunoreactive (TH-IR) axonal boutons surrounding the neural perikarya and proximal dendrites of...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)91622-7

    authors: Kubota Y,Inagaki S,Kito S,Takagi H,Smith AD

    更新日期:1986-03-05 00:00:00

  • Suppression of egg-laying during starvation in the snail Lymnaea stagnalis by inhibition of the ovulation hormone producing caudo-dorsal cells.

    abstract::Starvation inhibits egg-laying in the snail, Lymnaea stagnalis. In starved animals the neurosecretory Caudo-Dorsal Cells (CDC), which produce the egg-laying hormone, are hyperpolarized as compared to the CDC of controls. However, they are more responsive to repetitive intracellular stimulation, which induces the hormo...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(82)90528-5

    authors: Ter Maat A,Lodder JC,Veenstra J,Goldschmeding JT

    更新日期:1982-05-13 00:00:00

  • Glycoprotein M6a is present in glutamatergic axons in adult rat forebrain and cerebellum.

    abstract::Glycoprotein M6a is a neuronally expressed member of the proteolipid protein (PLP) family of tetraspans. In vitro studies suggested a potential role in neurite outgrowth and spine formation and previous investigations have identified M6a as a stress-regulated gene. To investigate whether the distribution of M6a correl...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.11.066

    authors: Cooper B,Werner HB,Flügge G

    更新日期:2008-03-04 00:00:00

  • Antihyperalgesic effect of systemic dexmedetomidine and gabapentin in a rat model of monoarthritis.

    abstract::The present study investigated the effects of systemic administration of dexmedetomidine, a selective alpha2 adrenergic receptor (alpha2AR) agonist, and gabapentin either alone or in combination on thermal hyperalgesia evoked by ankle joint inflammation. Monoarthritis of rat ankle joint was induced by an intra-articul...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.01.029

    authors: Zhang WS,Xu H,Xu B,Sun S,Deng XM,Zhang YQ

    更新日期:2009-04-06 00:00:00

  • Deficits in avoidance responding after paradoxical sleep deprivation are not associated with altered [3H]pirenzepine binding to M1 muscarinic receptors in rat brain.

    abstract::Previous work had indicated that animals that were sleep-deprived and then trained on a passive avoidance task show poor retention of the task 24 h later after being allowed to sleep freely again. Cholinergic involvement is suggested by the fact that this effect is prevented by treatment with the muscarinic agonist pi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(03)02688-x

    authors: Moreira KM,Hipólide DC,Nobrega JN,Bueno OF,Tufik S,Oliveira MG

    更新日期:2003-07-04 00:00:00

  • Vanadate ions: central nervous system action on glucoregulation.

    abstract::Vanadate (VO-3), an essential trace element with insulin-mimetic actions, produces systemic hyperglycemia following central administration in mice. The hyperglycemic effect is due to specific action of vanadate or its reduced form, vanadyl (VO2+); other ions of similar atomic weight (Cr, Mn) or structure (phosphate) h...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)90615-9

    authors: Amir S,Meyerovitch J,Shechter Y

    更新日期:1987-09-01 00:00:00

  • A consideration of sensory factors involved in motor functions of the basal ganglia.

    abstract::There is a sizeable literature concerning basal ganglia (BG) functioning that is based on data from experiments employing a method of analysis that is traditionally used with other motor areas. A brief review of this literature is presented and the following conclusion is reached: as compared to the success of traditi...

    journal_title:Brain research

    pub_type: 杂志文章,评审

    doi:10.1016/0165-0173(85)90010-4

    authors: Lidsky TI,Manetto C,Schneider JS

    更新日期:1985-06-01 00:00:00

  • Influence of the radioprotective agent WR 2721 on the striatal acetylcholinesterase activity in the rat.

    abstract::The radioprotective thiophosphate S-2(3 amino-propyl-amino) phosphorothioic acid (WR 2721) induced an early reduction of striatal acetylcholinesterase activity followed by an increase, when intraperitoneally injected to rats, although it does not cross the blood-brain barrier. These results were obtained using an orig...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90788-o

    authors: Clarençon D,Galonnier M,Testylier G,Fatôme M

    更新日期:1993-04-09 00:00:00

  • Involvement of TNF-alpha in glutamate-induced apoptosis in a differentiated neuronal cell line.

    abstract::We examined the involvement of tumor necrosis factor (TNF)-alpha on glutamate-induced cytotoxicity in a differentiated neuronal cell line. In this study, we used nerve growth factor (NGF)-differentiated PC12h cells. Glutamate cytotoxicity was assessed using the MTS and TUNEL assays. To detect TNF-alpha levels in cultu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.09.006

    authors: Kogo J,Takeba Y,Kumai T,Kitaoka Y,Matsumoto N,Ueno S,Kobayashi S

    更新日期:2006-11-29 00:00:00

  • Functional anatomy of GO/NO-GO discrimination and response selection--a PET study in man.

    abstract::The purpose of this study was to identify the functional fields activated in relation to the NO-GO decision. Nine healthy subjects participated in the study which consisted of two test positron emission tomography (PET) scans (GO/NO-GO task and response selection task) and one control scan. In the response selection t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:

    authors: Kawashima R,Satoh K,Itoh H,Ono S,Furumoto S,Gotoh R,Koyama M,Yoshioka S,Takahashi T,Takahashi K,Yanagisawa T,Fukuda H

    更新日期:1996-07-22 00:00:00

  • Neuroglial activation and Cx43 expression are reduced upon transplantation of human umbilical cord blood cells after perinatal hypoxic-ischemic injury.

    abstract::Glial cells play a crucial role in the pathomechanism of perinatal hypoxic-ischemic brain injury (HI) and are involved in the maintenance of a chronic state of inflammation that causes delayed neuronal damage. Activation of astrocytes is one factor prolonging brain damage and contributing to the formation of a glial s...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2012.05.066

    authors: Wasielewski B,Jensen A,Roth-Härer A,Dermietzel R,Meier C

    更新日期:2012-12-03 00:00:00

  • The site of the anti-emetic action of tachykinin NK1 receptor antagonists may exist in the medullary area adjacent to the semicompact part of the nucleus ambiguus.

    abstract::NK1 receptor antagonists have been shown to act centrally and to produce a broad-spectrum anti-emetic action. To determine precisely the site of this action, we microinjected GR205171, an NK1 receptor antagonist, into the left medulla oblongata in decerebrate paralyzed dogs. The right medulla was transected 2.5 mm ros...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)01324-9

    authors: Fukuda H,Nakamura E,Koga T,Furukawa N,Shiroshita Y

    更新日期:1999-02-13 00:00:00

  • Neuropeptide Y attenuates NMDA-induced phase shifts in the SCN of NPY Y1 receptor knockout mice in vitro.

    abstract::Neuropeptide Y (NPY) blocks the effect of light on the mammalian circadian clock during the subjective night. The present study explores the role of the NPY Y1 receptor in this interaction. The effect of NPY when co-applied with NMDA, a glutamate agonist that can mimic the effect of light, was examined in NPY Y1-/- mi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2004.07.037

    authors: Soscia SJ,Harrington ME

    更新日期:2004-10-08 00:00:00

  • Inhibition of GSK-3beta mediates expression of MMP-9 through ERK1/2 activation and translocation of NF-kappaB in rat primary astrocyte.

    abstract::Glycogen synthase kinase (GSK)-3beta and extracellular signal-regulated kinase (ERK) regulate several cellular signaling pathways in common, including embryonic development, cell differentiation and apoptosis. In this study, we investigated whether GSK-3beta inhibition is involved in ERK activation, which affects the ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.10.018

    authors: Kim SD,Yang SI,Kim HC,Shin CY,Ko KH

    更新日期:2007-12-01 00:00:00

  • Immediate or delayed mild hypothermia prevents focal cerebral infarction.

    abstract::The protective effect of mild hypothermia was studied in rodent models of both permanent and transient focal cerebral ischemia. In Expt. 1, Wistar rats were exposed to 6 h permanent ischemia by bilateral occlusion of both common carotid arteries and right middle cerebral artery. In Expt. 2, animals were exposed to 3 h...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)91428-h

    authors: Xue D,Huang ZG,Smith KE,Buchan AM

    更新日期:1992-07-31 00:00:00

  • Tachyphylaxis of dipsogenic activity to intracerebroventricular administration of angiotensins.

    abstract::Repeated intracerebroventricular (i.c.v.) administration of angiotensin II (AII) and angiotensin III (AIII) induced dipsogenic tachyphylaxis in the Sprague-Dawley rat. AIII caused a rapid suppression of drinking, whereas AII showed a progressive decline of water consumption with repeated injections. Tachyphylaxis due ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90010-8

    authors: Quirk WS,Wright JW,Harding JW

    更新日期:1988-06-14 00:00:00

  • Thyrotropin-releasing hormone: medullary site of action to induce gastric ulcers and stimulate acid secretion.

    abstract::This study evaluated the hypothesis that the dorsal motor nucleus (DMN) of the brainstem may mediate the ulcerogenic and acid-stimulatory effects of thyrotropin-releasing hormone (TRH) in rats. To accomplish this, intra-DMN microinjections of TRH (50 and 500 ng) were performed and their effects on acid secretion and g...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90295-8

    authors: Hernandez DE,Emerick SG

    更新日期:1988-08-30 00:00:00