Abstract：
:Vanadate (VO-3), an essential trace element with insulin-mimetic actions, produces systemic hyperglycemia following central administration in mice. The hyperglycemic effect is due to specific action of vanadate or its reduced form, vanadyl (VO2+); other ions of similar atomic weight (Cr, Mn) or structure (phosphate) have no effect. The effect of central vanadate to raise circulating glucose is blocked by coadministration of 3-O-methylglucose or polymyxin B, which prevent insulin- and vanadate-stimulated glucose transport. Finally, the central hyperglycemic effect is prevented by treatments which block sympathetic outflow from the CNS or diminish the levels of circulating epinephrine. These results show that vanadate is able to influence peripheral glucoregulation by increasing sympathetic outflow from the CNS. Moreover, they suggest that this effect is linked to action of VO-3 or its reduced form, VO2+, to stimulate glucose transport into neuronal cells.
journal_name
Brain Resjournal_title
Brain researchauthors
Amir S,Meyerovitch J,Shechter Ydoi
10.1016/0006-8993(87)90615-9subject
Has Abstractpub_date
1987-09-01 00:00:00pages
392-6issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(87)90615-9journal_volume
419pub_type
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