Prolactin response to morphine in intact and adrenalectomized lactating rats.

Abstract:

:To examine the hypothesis that the increased adrenocortical activity during lactation induced the loss of the prolactin (PRL) -releasing effect of morphine, we studied the effect of morphine in adrenalectomized (ADX) and sham-operated primiparous lactating Wistar rats. Animals were adrenalectomized 4 days after delivery. On day 11 of lactation (7 days after ADX), pups were separated from their mother 2 h before morphine or haloperidol injection. Intravenous injection of 5 mg/kg morphine did not change plasma PRL levels in the sham-operated lactating rats, but it resulted in a significant increase of plasma PRL levels in ADX lactating animals, with or without corticosterone replacement. Catalepsy following 10 mg/kg i.v. morphine was also markedly enhanced in ADX lactating animals. The PRL response to 0.5 mg/kg haloperidol was higher in ADX lactating animals than that in the controls. Morphine given 2 h after haloperidol treatment resulted in a further increase of plasma PRL in ADX, but not in the sham-operated lactating animals. These results suggest that adrenal hyperfunction may lead to a loss of sensitivity to morphine during lactation.

journal_name

Brain Res

journal_title

Brain research

authors

Kiem DT,Fekete MI,Bartha L,Nagy G,Makara GB

doi

10.1016/0006-8993(91)91530-e

subject

Has Abstract

pub_date

1991-11-01 00:00:00

pages

171-4

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(91)91530-E

journal_volume

563

pub_type

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