Abstract:
:Results from several studies indicate that cyclooxygenase-2 (COX-2) is involved in ischemic brain injury. The purpose of this study was to evaluate the neuroprotective effects of the selective COX-2 inhibitor nimesulide on cerebral infarction and neurological deficits in a standardized model of transient focal cerebral ischemia in rats. Three doses of nimesulide (3, 6 and 12 mg/kg; i.p.) or vehicle were administered immediately after stroke and additional doses were given at 6, 12, 24, 36 and 48 h after ischemia. In other set of experiments, the effect of nimesulide was studied in a situation in which its first administration was delayed for 3-24 h after ischemia. Total, cortical and subcortical infarct volumes and functional outcome (assessed by neurological deficit score and rotarod performance) were determined 3 days after ischemia. The effect of nimesulide on prostaglandin E(2) (PGE(2)) levels in the injured brain was also investigated. Nimesulide dose-dependently reduced infarct volume and improved functional recovery when compared to vehicle. Of interest is the finding that neuroprotection conferred by nimesulide (reduction of infarct size and neurological deficits and improvement of rotarod performance) was also observed when treatment was delayed until 24 h after ischemia. Further, administration of nimesulide in a delayed treatment paradigm completely abolished PGE(2) accumulation in the postischemic brain, suggesting that COX-2 inhibition is a promising therapeutic strategy for cerebral ischemia to target the late-occurring inflammatory events which amplify initial damage.
journal_name
Brain Resjournal_title
Brain researchauthors
Candelario-Jalil E,González-Falcón A,García-Cabrera M,León OS,Fiebich BLdoi
10.1016/j.brainres.2004.01.078subject
Has Abstractpub_date
2004-05-08 00:00:00pages
98-108issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899304002525journal_volume
1007pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The localization of the glycine cleavage system was examined in the rat brain by immunohistochemistry using an antibody to P-protein (a constituent of the system). In all sites studied, the enzyme was confined to the astrocytes. The intensity of astrocyte staining varied in different brain regions, with the strongest ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91436-5
更新日期:1991-12-13 00:00:00
abstract::This review provides a snapshot of the current ethical issues related to research with human brain organoids. The issues fall into the following main themes: research oversight; human biomaterials procurement and donor consent; translational delivery; animal research; and organoid consciousness and moral status. Each ...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2020.146653
更新日期:2020-04-01 00:00:00
abstract::The possibility of a functional relationship between noradrenaline and neurohypophyseal peptides in the control of cardiovascular function in the nucleus tractus solitarius of rats has been investigated. The hypotensive response to microinjections of noradrenaline (20 nmol) was abolished by simultaneous (but not prior...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90936-x
更新日期:1987-10-06 00:00:00
abstract::Experiments were carried out on UC-11MG human astrocytoma cells, a continuous cell line that expresses a broad range of the biochemical and electrophysiological properties found in well-differentiated astrocytes. Because of a number of recent reports that astrocytes may express receptors for a variety of neuro-active ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91676-6
更新日期:1992-10-02 00:00:00
abstract::We investigated the effect of aging on the responses to thermal and mechanical stimuli in rats. Young (3-5 months old) and aged (22-24 months old) male Sprague-Dawley rats were tested in the hot plate, high- and low-intensity radiant heat tail flick, and von Frey hair assays. Compared to young rats, aged rats displaye...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)01960-0
更新日期:2000-03-10 00:00:00
abstract::A gentle long-lasting handling produces persistent neurochemical and behavioural changes and attenuates the impairment in the behavioural reactivity to novelty induced by the prenatal exposure to diazepam (DZ) in adult male rat progeny. This study investigated the consequences of a late prenatal treatment with three G...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03282-1
更新日期:2002-10-25 00:00:00
abstract::The mismatch negativity is an electrophysiological marker of auditory change detection in the event-related brain potential and has been proposed to reflect an automatic comparison process between an incoming stimulus and the representation of prior items in a sequence. There is evidence for two main functional subcom...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.07.079
更新日期:2008-07-18 00:00:00
abstract::We have previously used organotypic cultures to study mechanisms regulating phenotypic expression of neurotransmitter characters in the brain. Our previous work indicated that nerve growth factor (NGF) specifically increased the activity of choline acetyltransferase (CAT) in striatal cholinergic interneurons. In the p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91136-x
更新日期:1987-06-02 00:00:00
abstract::Auditory transients (such as sound onset or a frequency transition within a continuous sound) are assumed to parse the auditory input into smaller units enabling the formation of unitary sound representations separately for each segment. This was discovered by using the mismatch negativity (MMN) component of the event...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.04.046
更新日期:2012-06-29 00:00:00
abstract::In scopolamine-treated (5.0 mg/kg, s.c.) rats hippocampal rhythmical slow activity (RSA) and neocortical low voltage fast activity (LVFA) occur only in close correlation with head movements, spontaneous changes in posture, or locomotion (Type I behavior). Previous work indicates that such scopolamine-resistant RSA and...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91500-e
更新日期:1992-11-27 00:00:00
abstract::Long-term potentiation (LTP) can be initiated in CA1, but not in the dentate, region of slices from rats with bilateral subcortical deafferentation at 8 week survival time. At about one week survival time, LTP is present in the CA1 region of all and also in the dentate of about 50% of slices. The results suggest that ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90981-g
更新日期:1990-06-04 00:00:00
abstract::The response of two populations of neurones in the substantia nigra (nigro-striatal compacta neurones and reticulata neurones) to microelectrophoretically administered putative neurotransmitters and stimulation of the ipsilateral striatum has been investigated in anaesthetized rats. There were marked differences betwe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90467-4
更新日期:1981-05-18 00:00:00
abstract::Previous studies have shown that chronic morphine increases levels of the G-protein subunits Gia and Goa, adenylate cyclase, cyclic AMP-dependent protein kinase, and certain phosphoproteins in the rat locus coeruleus, but not in several other brain regions studied, and that chronic morphine decreases levels of Gia and...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91111-d
更新日期:1991-05-10 00:00:00
abstract::Cerebrospinal fluid (c.s.f.) pressure and resistance to absorption have been studied in exteriorized fetuses (18 to 21 days gestation) from pregnant rats anaesthetised with pentobarbitone and in similarly anaesthetised postnatal rats at 1, 5, 10 and 30 days after birth and in adults. The resting c.s.f. pressure was lo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90172-6
更新日期:1987-05-01 00:00:00
abstract::Neurokinins, such as substance P (SP), modulate the reflex regulation of cardiovascular and respiratory function in the CNS, particularly in the nucleus tractus solitarius (NTS). There is considerable evidence of the action of SP in the NTS, but the precise effects have not yet been determined. Voltage-dependent Ca2+ ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.06.060
更新日期:2006-09-19 00:00:00
abstract::The involvement of bulbospinal pathways in the antinociceptive effect of clomipramine in experimental pain was studied. The antinociceptive effect of the antidepressant (0.5 mg/kg), intravenously injected, was evaluated after a unilateral lesion of the dorsolateral funiculus. The results showed that this effect was su...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00826-c
更新日期:1995-10-16 00:00:00
abstract::The neurons that produce gonadotrophin-releasing hormone (GnRH) are mainly found in the medial preoptic area (MPOA) and constitute a common final pathway to the control of luteinizing hormone (LH) surge on proestrus. The control of GnRH secretion depends on several neurotransmitters, such as serotonin (5-HT), noradren...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.01.045
更新日期:2007-04-20 00:00:00
abstract::Hemicholinium-3 (HCh-3) is a potent and specific inhibitor of the high-affinity choline transport process (HAChT) localized on cholinergic neurons. In this study, the specific binding of [3H]HCh-3 (120 Ci/mmol) was characterized in crude synaptic membranes prepared from rat brain. The binding of [3H]HCh-3 to forebrain...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90451-2
更新日期:1985-12-02 00:00:00
abstract::The preferential loss of GABAergic neurons in neocortex slab cultures after exposure to hypoxia was reinvestigated and confirmed using an improved morphometric analysis based on stereological principles. This preferential cell loss could be attenuated by treating the hypoxic slab cultures with the N-methyl-D-aspartate...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91031-7
更新日期:1989-10-30 00:00:00
abstract::It is well known that the nerve growth factor (NGF) may serve as a link between inflammation and hyperalgesia. Recent experiments showed that systemic injection of NGF dramatically stimulated the expression of brain-derived neurotrophic factor (BDNF) mRNA in the dorsal root ganglion (DRG). In the present study, we eva...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/S0006-8993(97)00048-6
更新日期:1997-02-28 00:00:00
abstract::The time course of autoradiographic binding of major second messengers in the rat brain was studied at 2, 7, and 24 h after withdrawal from butorphanol infusion. [3H]Forskolin and [3H]phorbol 12,13-dibutyrate (PDBu) were used to label adenylate cyclase and protein kinase C (PKC), respectively. Rats were rendered depen...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01127-0
更新日期:1999-03-13 00:00:00
abstract::Single unit activities of Y, X and W cells were recorded in the cat lateral geniculate nucleus to study how their responses to stationary light spots change with the cortical EEG. The shift from desynchronized to synchronized EEG drastically suppressed W cell activities, depressed both transient and sustained componen...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90102-3
更新日期:1988-07-12 00:00:00
abstract::Our previous studies demonstrated that only a few days of housing in an enriched environment increases response strength and paired-pulse depression in the auditory cortex of awake and anesthetized rats [Engineer, N.D., Percaccio, C.R., Pandya, P.K., Moucha, R., Rathbun, D.L., Kilgard, M.P., 2004. Environmental enrich...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.07.062
更新日期:2007-10-12 00:00:00
abstract::In the present experiment we examined the effect of progesterone upon dopamine (DA) release induced by a direct infusion of unlabeled L-dihydroxyphenylalanine (L-DOPA) into the caudate nucleus of freely behaving rats. Ovariectomized rats were implanted with a push-pull cannula directed at the caudate nucleus and subje...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90150-9
更新日期:1989-08-07 00:00:00
abstract::In order to determine the origin of the catecholamine innervation of the rat piriform cortex (PC), we combined retrograde transport of the B subunit of the cholera toxin (CTb) with tyrosine hydroxylase (TH) immunohistochemistry. A substantial number of CTb retrogradely labeled cells was found in the parabrachial pigme...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01279-6
更新日期:1996-02-26 00:00:00
abstract::Acute and chronic abuses of psychostimulant drugs such as methamphetamine (METH) have been known to cause cell death. In particular, neurotoxicity caused by such drugs is one of the most serious adverse events in humans. Although various effects on neuronal cells caused by METH have been studied, the cellular and mole...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.07.043
更新日期:2010-09-17 00:00:00
abstract::The contribution of opioid receptors in the nucleus accumbens to contextual and auditory fear conditioning was examined. Impairment in contextual fear conditioning was found when training occurred under accumbal infusions of the opioid receptor agonist morphine in a dose-dependent and receptor specific fashion, only w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.04.019
更新日期:2013-06-23 00:00:00
abstract::The lack of the glycine transporter 1 (GlyT1) leads to early postnatal death due to failure of respiratory network activity. Here we demonstrate a segregated expression of GlyT1 on different astroglial cell populations of the ventral respiratory group. In TgN(hGFAP-EGFP) mice a combined immunohistochemical and electro...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.08.089
更新日期:2006-11-13 00:00:00
abstract::An extensive mapping of the caudate-putamen in rat for intracranial self-stimulation (ICS) site was undertaken to provide addtional support for the role of dopamine in brain-stimulation reward. Eight-seven per cent of the placements in the neostriatum supported ICS, with self-stimulation rates greater than 250/15 min ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90615-6
更新日期:1976-03-12 00:00:00
abstract::The binding of the adenosine receptor agonists, [3H]N-ethylcarboxamidoadenosine (NECA) and [3H]cyclohexyladenosine (CHA) to membrane preparations and to cryostat sections of the rat brain was examined. The xanthine derivative, 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) was ca. 500-fold more effective at A1 than at A2 ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90589-5
更新日期:1986-03-19 00:00:00