Abstract：
:A brief noxious heat stimulus applied to half of the receptive field of each cutaneous nociceptor resulted in most cases in the enhanced responsiveness of that half to subsequent heat stimuli (sensitization). No change in responsiveness to heat was observed in the other half of the receptive field, indicating that the effects of heat sensitization did not spread from the site of injury. In certain instances, the receptive field area increased, but the enlargement occurred only within the area of injury. The latter suggests the existence of outlying terminal endings of the parent axon that are normally unresponsive to non-injurious mechanical or heat stimuli but become responsive to these stimuli following injury.
journal_name
Brain Resjournal_title
Brain researchauthors
Thalhammer JG,LaMotte RHdoi
10.1016/0006-8993(82)90364-xsubject
Has Abstractpub_date
1982-01-14 00:00:00pages
257-65issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(82)90364-Xjournal_volume
231pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The effects of the epileptogenic agent, penicillin, on excitatory and inhibitory postsynaptic potentials (EPSPs and IPSPs) were studied in the hippocampal in vitro slice preparation. The actions of penicillin were compared to those of bicuculline, an antagonist of gamma-aminobutyric acid. Neither substance enhanced mo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90119-5
更新日期：1980-02-03 00:00:00
abstract：:The [14C]2-deoxy-D-glucose technique was used to test the effects of central muscarinic stimulation on local cerebral glucose utilization (LCGU) in rats. Systemic administration of the muscarinic agonist oxotremorine (OXO, 0.7 mg/kg, ip) increased LCGU in brain regions involved in motor function: the sensorimotor cort...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91100-8
更新日期：1981-12-07 00:00:00
abstract：:Previous research has shown that injection of morphine into the ventral tegmental area (VTA) facilitates the onset of maternal behavior in virgin female rats, and injection of the opioid antagonist naltrexone into the VTA disrupts the onset of maternal behavior in parturient rats. Placentophagia -- ingestion of placen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.01.015
更新日期：2009-03-19 00:00:00
abstract：:Dopamine-containing amacrine cells of rhesus monkey were found everywhere outside of the foveola in whole, flat retinas by the formaldehyde-glutaraldehyde fluorescent method. There were about 7500 such cells in a single retina and their density, determined by cell counts and measured by a nearest neighbor method, was ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91174-0
更新日期：1984-11-19 00:00:00
abstract：:Peripheral input to lamina VIII interneurones was investigated by using extracellular and/or intracellular records from them. The interneurones were located in the L4-L5 spinal segments and projected to contralateral motor nuclei in the L7 segment. They constituted a non-homogeneous population but their input from mus...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91618-q
更新日期：1990-12-10 00:00:00
abstract：:Regeneration of descending supraspinal projections were identified in adult goldfish following administration of HRP to different levels of the spinal cord. While in the untreated normal fish 17 nuclei were shown to project into the spinal cord, only 11 of them seem to have participated in the process of regeneration....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90159-k
更新日期：1993-08-27 00:00:00
abstract：:Sleep deprivation leads to cognitive impairments in humans and, if sustained for 2-3 weeks in rats, it is invariably fatal. It has been suggested that neural activity associated with waking, if it is not interrupted by periods of sleep, may damage brain cells through excitotoxic or oxidative mechanisms and eventually ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01768-0
更新日期：1999-09-04 00:00:00
abstract：:The distribution of creatine kinase BB-isoenzyme in the human central nervous system (CNS) was investigated immunohistochemically and the findings were compared with the distributions of tubulin and astroprotein. Creatine kinase BB-isoenzyme existed both in neurons and astrocytes, and was universally distributed withi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91338-0
更新日期：1983-04-11 00:00:00
abstract：:Structural changes induced by high frequency (HF) stimulation on granule cells of the hippocampal dentate gyrus of rats with inborn high (HP) and low (LP) learning capacity was examined in this study. Two types of axodendritic synapses were processed morphometrically; the axonal bouton on dendritic shafts and those ma...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90371-h
更新日期：1990-12-24 00:00:00
abstract：:Due to the structural similarity to N-methyl-4-phenyl pyridinium (MPP(+)), paraquat might induce dopaminergic toxicity in the brain. However, its blood--brain barrier (BBB) penetration has not been well documented. We studied the manner of BBB penetration and neural cell uptake of paraquat using a brain microdialysis ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02577-x
更新日期：2001-07-06 00:00:00
abstract：:Oligodendrocyte precursor cells (OPCs) react rapidly to brain and spinal cord injuries. This reaction is characterized by the retraction of cell processes, cell body swelling and increased expression of the NG2 chondroitin sulfate proteoglycan. Reactive OPCs rapidly divide and accumulate surrounding the injury site wh...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2015.07.026
更新日期：2016-05-01 00:00:00
abstract：:The retinal spreading depression has been used as a tool to investigate the action of nitric oxide (NO) as a diffusible neurotransmitter which in many cases acts by raising the cGMP level in target cells. The role of NO as a vasodilating agents has been well-established and it has been suggested that the vasodilatatio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00737-b
更新日期：1995-09-11 00:00:00
abstract：:High-affinity uptake of norepinephrine (NE) and dopamine (DA) were determined in synaptosomes of brain regions from four genetically related inbred rat strains, all derived from the Wistar-Kyoto rat: SHR, WKY, WKHA and WKHT strains. SHRs express hypertension and hyperactivity, WKHAs express hyperactivity alone, WKHTs ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91369-p
更新日期：1992-07-17 00:00:00
abstract：:Neurotrophins regulate many aspects of neuronal function and activity. Specifically, the binding of Brain-derived neurotrophic factor (BDNF) to Tyrosine receptor kinase-B (TrkB) or its truncated version, TrkB-T1, can cause growth and differentiation or dominant inhibition of receptor signaling, respectively. There is ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.06.008
更新日期：2017-08-15 00:00:00
abstract：:The size differences in the midsagittal cerebellum, its individual lobules and its layers are studied in homozygous diabetic (HOM) and heterozygous Brattleboro rats on postnatal days 12, 24 and 180. As has been reported for total cerebellar weight, no significant reduction in cerebellar size in HOM rats occurs at day ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90296-8
更新日期：1986-05-01 00:00:00
abstract：:The mechanism of the antinociceptive effect of the tricyclic antidepressant imipramine was investigated in mice. Intrathecal (i.t.) administration of imipramine produced dose-dependent antinociception in the tail-pinch and tail-flick tests with ED50 values (95% confidence limit) of 27.5 (17.0-43.9) and 20.2 (12.6-32.2...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90344-9
更新日期：1992-05-22 00:00:00
abstract：:Intracellular recordings were obtained from facial motoneurons in anesthetized rats. The effects of iontophoretically applied serotonin were compared to those of the excitatory amino acids glutamate and DL-homocysteic acid (DLH), and the inhibitory amino acids, glycine, GABA and muscimol, under various conditions of m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90838-1
更新日期：1982-05-06 00:00:00
abstract：:The 'wobbler' mutant mouse can be recognized at about 4 weeks of age by its tremor and atrophy of forelimb muscles. In addition to degeneration of spinal motoneurons, especially in cervical spinal cord, selected bulbar motoneurons have also been reported to degenerate in the mutant. We examined a cranial motor nucleus...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91363-1
更新日期：1987-02-24 00:00:00
abstract：:Tactile stimulation of the body surface elicited climbing fiber responses in 5% of the 839 Purkinje cells recorded in the caudal posterior vermis (lobules VII-IX) of cats anesthetized with sodium pentobarbital. The cells responsive to tactile stimulation were mainly encountered around the prepyramidal fissure between ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90084-o
更新日期：1990-06-11 00:00:00
abstract：:(1) Synaptic transmission was studied in isolated transverse hippocampal slices from guinea pigs. Extracellular evoked potentials were recorded in the region CA1. (2) Changing the normal perfusion solution (containing 2 mM Ca2+) to calcium-free Ringer abolished synaptic transmission which was again restored by adding ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91327-x
更新日期：1980-07-21 00:00:00
abstract：:Post-hypoxic myoclonus is a movement disorder characterized by brief, sudden involuntary muscle jerks. Although the mechanism underlying this disorder remains unclear, earlier pharmacological studies indicated that aberrant activity of specific neuronal circuitry in the central nervous system causes this disorder. In ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.08.027
更新日期：2005-10-19 00:00:00
abstract：:Rat central nervous system (CNS) tissue sections were immunostained by the peroxidase-anti-peroxidase (PAP) method using a rabbit serum directed against rat liver 5'-nucleotidase. In paraffin sections from the brains of 60-day-old rats 5'-nucleotidase immunoreactivity occurred in the same white-matter regions as myeli...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90090-2
更新日期：1985-05-01 00:00:00
abstract：:Alteration in the blood-nerve barrier may be of primary importance in the development of experimental lead neuropathy. Using quantitative track autoradiography, we have directly demonstrated that there is a 15-fold increase in the rate of 210Pb accumulation in the endoneurium 70 days after the onset of chronic intoxic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90318-8
更新日期：1981-11-23 00:00:00
abstract：:The roles of noradrenergic and serotonergic projections to the hippocampus were investigated with respect to their involvement in the intracranial self-stimulation of this structure. In the first study, 6-hydroxydopamine-induced lesions of the dorsal tegmental noradrenergic bundle, which depleted hippocampal NE by 97%...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90136-6
更新日期：1977-11-04 00:00:00
abstract：:In a rat model of peripheral inflammation and hyperalgesia, dynorphin A(1-8)-like immunoreactive (DYN-LIr) spinal neurons were examined for contacts from calcitonin gene-related peptide-like immunoreactive (CGRP-LIr) varicosities using a double-label PAP method. Ipsilateral to the inflammation, CGRP-LIr varicosities c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90213-2
更新日期：1988-12-13 00:00:00
abstract：:The second of two targets (T2) presented in a rapid visual stream is often missed when presented shortly after the first (T1). This phenomenon has been referred to as the attentional blink. Here we show that the presentation of a synchronous sound enables T2 to escape the attentional blink, to the extent that performa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.01.070
更新日期：2008-11-25 00:00:00
abstract：:Horseradish peroxidase (HRP) injected into developing limb buds of Xenopus laevis tadpoles is carried by retrograde axonal transport to the somata of motoneurones in the ventral horn. Small injection of 10% HRP were found to remain well localised to specified sites in the limb bud. Two types of labelled cells were fou...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)91067-8
更新日期：1977-10-07 00:00:00
abstract：:Regulation of tyrosine hydroxylase (TH) by second messenger pathway activators was examined in rat olfactory bulb cell cultures. The number of TH-immunoreactive neurons was increased 2-3-fold by 36 h treatments with forskolin (Fsk, 10(-6) M) or phorbol myristate acetate (PMA, 10(-7) M), but was not significantly incre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(09)90015-4
更新日期：1994-09-26 00:00:00
abstract：:We examined regional cerebral metabolic rates for glucose (rCMRglc) and brain incorporation coefficients (k*) of each of three intravenously infused fatty acid radiotracers, [9,10-(3H)]palmitate ([3H]PAM), [1-(14C)]arachidonate ([14C]AA) and [1-(14C)]docosahe-xaenoate ([14C]DHA), in awake rats fully kindled by once-da...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00854-2
更新日期：1996-12-16 00:00:00
abstract：:Alcohols and volatile anesthetics modulate the function of cys-loop ligand-gated ion channels, binding to a putative site between transmembrane domains two and three. The extracellular linker between these two domains is important in the transduction of the gating signal from the glycine binding site to the channel ga...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.03.031
更新日期：2007-06-04 00:00:00
