Motoneuron loss in the abducens nucleus of wobbler mice.

Abstract:

:The 'wobbler' mutant mouse can be recognized at about 4 weeks of age by its tremor and atrophy of forelimb muscles. In addition to degeneration of spinal motoneurons, especially in cervical spinal cord, selected bulbar motoneurons have also been reported to degenerate in the mutant. We examined a cranial motor nucleus and found a 31% loss of abducens motoneurons in 4-5-week-old wobbler mice as compared to age-matched control mice.

journal_name

Brain Res

journal_title

Brain research

authors

LaVail JH,Koo EH,Dekker NP

doi

10.1016/0006-8993(87)91363-1

subject

Has Abstract

pub_date

1987-02-24 00:00:00

pages

127-32

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(87)91363-1

journal_volume

404

pub_type

杂志文章
  • Subpallidal-pedunculopontine projections but not subpallidal-mediodorsal thalamus projections contribute to spontaneous exploratory locomotor activity.

    abstract::The contribution of the pedunculopontine nucleus to exploratory locomotion was investigated in rats. Locomotor activity recorded in a standard open-field apparatus was increased more than two-fold when wooden panels were inserted. This novelty-elicited locomotion was reduced significantly when procaine was injected bi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)90584-2

    authors: Mogenson GJ,Wu M,Tsai CT

    更新日期:1989-04-24 00:00:00

  • Activity of A9 and A10 dopaminergic neurons in unrestrained rats: further characterization and effects of apomorphine and cholecystokinin.

    abstract::The activity of single dopaminergic (DA) neurons (total n = 77) in the midbrain of awake, unrestrained rats was examined. The firing rates and patterns of ventral tegmental area (A10) cells (n = 39) were similar to those of identified DA neurons in anesthetized and paralyzed rats. Unit activity was briefly stimulated ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)90988-7

    authors: Freeman AS,Bunney BS

    更新日期:1987-03-03 00:00:00

  • The role of the dorsal and ventral hippocampus in fear and memory of a shock-probe experience.

    abstract::The roles of the dorsal and ventral hippocampus in fear and memory are unclear. This study examined the effects of temporary inactivation of the dorsal or ventral hippocampus on unconditioned and conditioned fear, using the shock-probe test. In Experiment 1, rats received either dorsal or ventral hippocampal infusions...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.11.041

    authors: McEown K,Treit D

    更新日期:2009-01-28 00:00:00

  • Long-term potentiation in Schaffer collateral and commissural systems of the hippocampus: in vitro study in rats pretreated with kainic acid.

    abstract::Experiments were carried out on hippocampal slices from rats pretreated with a unilateral intraventricular injection of kainic acid. The kainic acid produced a lesion of the CA3 area in the hippocampus ipsilateral to the site of injection. The resulting neuroanatomically modified hippocampal slices allowed the indepen...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90570-x

    authors: Wheal HV,Lancaster B,Bliss TV

    更新日期:1983-08-08 00:00:00

  • Effect of 2450 MHz microwave energy on the blood-brain barrier to hydrophilic molecules. B. Effect on the permeability to HRP.

    abstract::Alteration of blood-brain barrier (BBB) permeability by 2450 MHz CW microwaves was assessed semi-quantitatively after intravenous injection of horseradish peroxidase (HRP) and exposure of conscious, unrestrained rats to incident power densities of 0, 20 or 65 mW/cm2 for 30, 90 or 180 min. Additional rats were exposed ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-0173(84)90022-5

    authors: Williams WM,Del Cerro M,Michaelson SM

    更新日期:1984-05-01 00:00:00

  • Single unit response of noradrenergic, serotonergic and dopaminergic neurons in freely moving cats to simple sensory stimuli.

    abstract::The response of noradrenergic (NE), serotonergic (5-HT), and dopaminergic (DA), neurons to repeated presentations (once/2 s for 64 trials) of phasic auditory (click) and visual (flash) stimuli was examined in freely moving cats. All 3 groups of neurons displayed similar response latencies and somewhat similar duration...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)90546-9

    authors: Rasmussen K,Strecker RE,Jacobs BL

    更新日期:1986-03-26 00:00:00

  • Decarboxylation of L-dopa by cultured mouse astrocytes.

    abstract::Cultured astrocytes contain immunologically specific aromatic L-amino acid decarboxylase (AADC) protein and express the AADC gene. Following incubation with L-Dopa, glial cultures synthesize and metabolize dopamine. The addition of pyridoxal 5-phosphate did not change the rate of dopamine synthesis. The formation of d...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90592-b

    authors: Juorio AV,Li XM,Walz W,Paterson IA

    更新日期:1993-10-29 00:00:00

  • Autoradiography of [3H]cytochalasin B binding in rat brain.

    abstract::A technique is described for the autoradiographic localization of D-glucose inhibitable cytochalasin B binding in fresh frozen sections of rat brain. The technique has been used to study the regional distribution of glucose transporter proteins. Binding sites within the cerebellum and hippocampus were more concentrate...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)91552-1

    authors: Tucker SP,Cunningham VJ

    更新日期:1988-05-31 00:00:00

  • Analysis of anti-depressant potential of curcumin against depression induced male albino wistar rats.

    abstract::The present study investigated the antidepressant potential of curcumin in olfactory bulbectomy and forced swimming test models of depression in male albino rats under chronic treatment. The experimental animals were divided into four groups, and curcumin was administered for 45 days. Our results showed that the curcu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2016.03.010

    authors: Chang XR,Wang L,Li J,Wu DS

    更新日期:2016-07-01 00:00:00

  • GYKI 52466 has positive modulatory effects on AMPA receptors.

    abstract::The 2,3-benzodiazepine derivative GYKI 52466 has been well characterized as a negative modulator of AMPA-type glutamate receptors. The present study re-examined the effects of GYKI 52466 on AMPA receptor-mediated currents in patches excised from pyramidal neurons in the hippocampal CA1 field and found that this drug h...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)03323-0

    authors: Arai AC

    更新日期:2001-02-23 00:00:00

  • Involvement of nitric oxide in the induction of interleukin-1 beta in microglia.

    abstract::In response to in vitro stimulation with lipopolysaccharide (LPS), microglia induce the production of the inflammatory cytokine interleukin-1 beta (IL-1β) together with nitric oxide (NO) and superoxide anion (O2(-)). Here we investigated the role of NO and O2(-) in the signaling mechanism by which IL-1β is induced in ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.08.030

    authors: Sudo K,Takezawa Y,Kohsaka S,Nakajima K

    更新日期:2015-11-02 00:00:00

  • Effects of probenecid on the elicitation of spreading depression in the rat striatum.

    abstract::Spreading depression (SD) is a wave of cellular depolarization which contributes to neuronal damage in experimental focal ischaemia, and may also underlie the migraine aura. The purpose of this study was to examine the effects of probenecid, an inhibitor of organic anion transport, on K+-evoked SD in vivo. Microdialys...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00434-4

    authors: Taylor DL,Urenjak J,Zilkha E,Obrenovitch TP

    更新日期:1997-08-01 00:00:00

  • Theta and alpha oscillatory responses differentiate between six-to seven-year-old children and adults during successful visual and auditory memory encoding.

    abstract::The healthy maturation of the brain is one of the intriguing topics that need to be investigated to understand human brain and child development. The present study aimed to investigate the development of memory processes both for auditory and visual memory using electroencephalography (EEG)-Brain Dynamics methodologie...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147042

    authors: Güntekin B,Uzunlar H,Çalışoğlu P,Eroğlu-Ada F,Yıldırım E,Aktürk T,Atay E,Ceran Ö

    更新日期:2020-11-15 00:00:00

  • A linked active transport system for Na+ and K+ in a glial cell line.

    abstract::Ouabain (5 X 10(-4) M) induced a 6-fold increase in intracellular Na+ and a 65% loss of cellular K+ in C6 glial cells which was accompanied by a 12 mV decrease in the resting membrane potential. Following ouabain washout intracellular ion concentrations and the membrane potential returned to control levels suggesting...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(76)90649-1

    authors: Kukes G,De Vellis J,Elul R

    更新日期:1976-03-05 00:00:00

  • Ontogenesis of chromogranin A and B and catecholamines in rat adrenal medulla.

    abstract::The ontogenesis of chromogranins A and B and catecholamines was investigated for rat adrenal medulla. The chromogranins, the major secretory peptides of chromaffin granules, were characterized by one- and two-dimensional immunoblotting. Chromogranin B appeared identical in fetal and postnatal adrenals. On the other ha...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)91475-3

    authors: Schober M,Fischer-Colbrie R,Winkler H

    更新日期:1989-01-23 00:00:00

  • Influence of brain-derived neurotrophic factor (val66met) genetic polymorphism on the ages of onset for heroin abuse in males.

    abstract::Previous studies have shown that one of the genetic variants BDNF val66met polymorphism is associated with drug addiction. Age at onset for drugs abuse has also been regularly cited as a factor associated with high genetic predispositions. We conducted an exploratory research to investigate the association of BDNF val...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.07.022

    authors: Hou H,Qing Z,Jia S,Zhang X,Hu S,Hu J

    更新日期:2010-09-24 00:00:00

  • Lectin reactivity of PNPF, a polyornithine-binding neurite-promoting factor.

    abstract::The fate of dissociated neurons from 8-day chick embryo ciliary ganglia, cultured in serum-containing media on polyornithine substrata, is influenced by two different macromolecular factors. The neurons will die within 24 h in the absence of CNTF, the eye-derived ciliary neuronotrophic factor. Even when supported by C...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(82)90175-4

    authors: Adler R,Manthorpe M,Varon S

    更新日期:1982-12-01 00:00:00

  • Tonic D2-mediated attenuation of cortical excitation in nucleus accumbens neurons recorded in vitro.

    abstract::The effects of dopamine D1 and D2 selective drugs on the responses evoked in accumbens neurons by stimulation of cortical afferents were studied in an in vitro brain slice preparation. The D2-specific antagonist sulpiride (1-10 microM) increased, whereas the D2 agonist quinpirole (1-20 microM) occasionally attenuated ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)90263-1

    authors: O'Donnell P,Grace AA

    更新日期:1994-01-14 00:00:00

  • Developmental changes of protein substrates of Ca2+/calmodulin-dependent protein kinase II in the rat forebrain.

    abstract::We previously reported that the level of Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) alpha and beta proteins increases with postnatal age. In the present study, we investigated the developmental changes in whole protein substrates of CaM kinase II as compared with those of cAMP-dependent protein kinase...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)90861-3

    authors: Sugiura H,Yamauchi T

    更新日期:1994-10-03 00:00:00

  • Cytosolic prostaglandin E2 synthase (cPGES) expression is decreased in discrete cortical regions in psychiatric disease.

    abstract::The number of adults in the US affected by bipolar disorder, depression, or schizophrenia is approaching 15 million. Despite decades of research, etiologies of these illnesses remain elusive. Theories of aberrant brain morphology, neurotransmission, and signal conduction have provided the heuristic framework for a lar...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.05.048

    authors: Maida ME,Hurley SD,Daeschner JA,Moore AH,O'Banion MK

    更新日期:2006-08-04 00:00:00

  • Membrane currents elicited by the epileptogenic drug pentylenetetrazole in the native oocyte of Xenopus laevis.

    abstract::The effects of the epileptogenic agent pentylenetetrazole (PTZ) on membrane currents of native oocytes of Xenopus laevis were studied. PTZ elicits a response that consists of two inward currents. The first one is interpreted to be due to a decrease of potassium permeability since: (1) the input resistance is increased...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90225-k

    authors: Madeja M,Musshoff U,Kuhlmann D,Speckmann EJ

    更新日期:1991-07-05 00:00:00

  • Chronic exposure to alcohol during development alters the membrane properties of cerebellar Purkinje neurons in culture.

    abstract::The active and passive membrane properties of developing Purkinje neurons in control cultures and cultures chronically treated with 20 or 40 mM ethanol for 1 or 2 weeks were examined using whole-cell current-clamp techniques. The membrane properties were characterized by the features of the voltage responses evoked by...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90707-3

    authors: Gruol DL

    更新日期:1991-08-30 00:00:00

  • Gangliosides modulate Schwann cell proliferation and morphology.

    abstract::We examined the effect of gangliosides on Schwann cell cultures isolated from neonatal rat sciatic nerves. Addition of gangliosides (GM1, GM3, and ganglioside mixture) at concentrations between 0.25 and 2 mg/ml significantly diminished both the baseline rate of proliferation of the Schwann cells and their response to ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90442-8

    authors: Sobue G,Taki T,Yasuda T,Mitsuma T

    更新日期:1988-12-06 00:00:00

  • Prenatal exposure to diazepam and alprazolam, but not to zolpidem, affects behavioural stress reactivity in handling-naïve and handling-habituated adult male rat progeny.

    abstract::A gentle long-lasting handling produces persistent neurochemical and behavioural changes and attenuates the impairment in the behavioural reactivity to novelty induced by the prenatal exposure to diazepam (DZ) in adult male rat progeny. This study investigated the consequences of a late prenatal treatment with three G...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)03282-1

    authors: Cannizzaro C,Martire M,Steardo L,Cannizzaro E,Gagliano M,Mineo A,Provenzano G

    更新日期:2002-10-25 00:00:00

  • Soma size and oxidative enzyme activity in normal and chronically stimulated motoneurones of the cat's spinal cord.

    abstract::In normal adult cats we measured the density of staining for the activity of succinate dehydrogenase (SDH staining) in ventral horn cells of different sizes. The measurements were restricted to that part of the lumbar ventral horn (L6-L7) which is known to contain motoneurones of the peroneal nerve. A statistically si...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)91542-8

    authors: Donselaar Y,Kernell D,Eerbeek O

    更新日期:1986-10-15 00:00:00

  • Effect of acute mitochondrial dysfunction on hyperexcitable network activity in rat hippocampus in vitro.

    abstract::Metabolic stress imposed by epileptic seizures can result in mitochondrial dysfunction, believed to act as positive feedback on epileptogenesis and seizure susceptibility. As the mechanism behind this positive feedback is unclear, the aim of the present study was to investigate the causal link between acute mitochondr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147193

    authors: Andreasen M,Nedergaard S

    更新日期:2021-01-15 00:00:00

  • Alterations of adenosine A1 receptors in morphine dependence.

    abstract::The possibility that central adenosine A1 and A2a receptors mediate opiate dependence was examined in morphine-treated mice using radioligand binding methods. Mice treated with morphine for 72 h demonstrated significant increases in naloxone precipitated abstinence behaviors of jumping, wet-dog shakes, teeth chatterin...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)90990-3

    authors: Kaplan GB,Leite-Morris KA,Sears MT

    更新日期:1994-09-19 00:00:00

  • Simulation studies of learning in an informon network.

    abstract::A single informon reproduces classical conditioning to compound stimuli under a wide range of conditions during reinforcement and non-reinforcement; it also reproduces simple operant conditioning. A network of 210 informons with 8400 simultaneouslly varying pathways has been simulated; it can learn to recognize handpr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(76)90574-6

    authors: Uttley AM

    更新日期:1976-01-30 00:00:00

  • Termination of a separate (proprioceptive?) cuneothalamic tract from external cuneate nucleus in monkey.

    abstract::The termination of a pathway recently discovered in monkey, from the external cuneate nucleus (ECN) to the thalamus, has been investigated with the degeneration method. A previous HRP study showed that the projection is crossed. The ECN fibers terminate a wedge-shaped zone located dorsally in the rostral half of the c...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)90856-8

    authors: Boivie J,Boman K

    更新日期:1981-11-16 00:00:00

  • Immunohistochemical detection of Bax and Bcl-2 proteins in gerbil hippocampus following transient forebrain ischemia.

    abstract::Time-course expression of Bax and Bcl-2 proteins, identified as apoptosis-regulating molecules, was assessed in gerbil hippocampus following transient forebrain ischemia. Brain sections from animals sacrificed at 48, 72, 96 h and 7 days following 5 min ischemia were immunohistochemically evaluated using polyclonal ant...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)01436-5

    authors: Hara A,Iwai T,Niwa M,Uematsu T,Yoshimi N,Tanaka T,Mori H

    更新日期:1996-03-04 00:00:00