Long-term potentiation in Schaffer collateral and commissural systems of the hippocampus: in vitro study in rats pretreated with kainic acid.

abstract：:Glutamate is an excitatory neurotransmitter implicated in the pathogenesis of psychiatric disorders. Glutamate results in the activation of an enzyme called glycogen synthase kinase-3 (GSK-3) acting through N-methyl-d-aspartate (NMDA) receptors. Impaired expression of GSK-3 affects behavior and neurochemicals level in...

journal_title：Brain research

authors： Walia V,Garg C,Garg M

更新日期：2019-02-01 00:00:00

abstract：:Peripheral nerve injury in animals can cause neuropathic pain often expressed in the form of hyperalgesia and allodynia. Spinal nerve ligation, in which the fifth and sixth lumbar (L5 and L6) or only the L5 spinal nerve is ligated and cut, is a model commonly used to produce neuropathic pain. The purpose of the presen...

journal_title：Brain research

authors： Shehab SA,Al-Marashda K,Al-Zahmi A,Abdul-Kareem A,Al-Sultan MA

更新日期：2008-05-07 00:00:00

abstract：:Acute noradrenergic stimulation has previously been shown to stimulate brain (Na+, K+)-adenosine triphosphatase activity. Effects of repeated stimulation with piperoxane were examined in the present study. Daily piperoxane increased ouabain binding, measured 24 h after the last dose, after 4 days or 3 weeks treatment;...

journal_title：Brain research

authors： Swann AC,Grant SJ,Jablons D,Maas JW

更新日期：1981-06-01 00:00:00

abstract：:The HSD2 (11-beta-hydroxysteroid dehydrogenase-type 2 enzyme) containing neurons of the nucleus tractus solitarius (NTS) become activated during low-sodium and high-aldosterone states such as hypovolemia. This response may be due to hormonal and/or neural signals. Hormonal signals may activate neurons in the area post...

journal_title：Brain research

authors： Shin JW,Loewy AD

更新日期：2009-12-08 00:00:00

abstract：:We examined the effects of nicotinic drugs on the metabolites of [3H]dopamine (DA) released from rat striatal synaptosomes in comparison with the effects of high K+ and methamphetamine stimulation. The pattern of outflow of [3H]DA and its metabolites induced by nicotine stimulants, acetylcholine (ACh), nicotine and lo...

journal_title：Brain research

authors： Takano Y,Sakurai Y,Kohjimoto Y,Honda K,Kamiya HO

更新日期：1983-11-21 00:00:00

abstract：:Synaptosomes prepared from fresh human cerebral cortex were shown to be morphologically similar to those from other species. On incubation, they took up oxygen at a high and linear rate and accumulated potassium against a concentration gradient. In response to depolarization by raised extracellular K+ or addition of v...

journal_title：Brain research

authors： Dodd P,Hardy JA,Oakley AE,Strong AJ

更新日期：1981-11-16 00:00:00

abstract：:A double-staining immunocytochemical study was done in ovariectomized (OVX) female rats that were either treated with 17beta-estradiol (E(2)) (OVX+E(2)) to produce an approximate circulating level of 30 pg/ml plasma, or not-treated with E(2) (OVX), to investigate the distribution of subfornical organ (SFO) neurons tha...

journal_title：Brain research

authors： Rosas-Arellano MP,Solano-Flores LP,Ciriello J

更新日期：1999-08-07 00:00:00

abstract：:In this study, we have identified and characterized 5-HT3-like receptors in the rat medial prefrontal cortex (mPFc), an area with a moderate density of 5-HT3 binding sites, using the techniques of single unit recording and microiontophoresis. The microiontophoresis of the 5-HT3 receptor agonist 2-methylserotonin (2-Me...

journal_title：Brain research

authors： Ashby CR Jr,Minabe Y,Edwards E,Wang RY

更新日期：1991-06-07 00:00:00

abstract：:The pontine respiratory neurons (PRG) in the 'pneumotaxic centre' have been hypothesized to contribute to phase-switching of neural respiratory activity, especially in terminating inspiration. To define the neural elements involved in phase-switching, we recorded respiratory neurons extra- and intracellularly in anest...

journal_title：Brain research

authors： Dick TE,Bellingham MC,Richter DW

更新日期：1994-02-14 00:00:00

abstract：:A selective 5-HT reuptake inhibitor, fluvoxamine (10 and 30 mg/kg, i.p.) suppressed long-term potentiation (LTP) in the hippocampal CA1 field of anesthetized rats. Fluvoxamine (30 mg/kg, i.p.)-induced suppression of LTP was completely reversed by the 5-HT(1A) receptor antagonist NAN-190 (0.5 mg/kg, i.p), but not by th...

journal_title：Brain research

authors： Kojima T,Matsumoto M,Togashi H,Tachibana K,Kemmotsu O,Yoshioka M

更新日期：2003-01-03 00:00:00

abstract：:The purpose of the present study was to investigate the possible involvement of hippocampal NMDA (N-methyl-d-aspartate) receptors in spatial memory in rats by means of intrahippocampal injection of an NMDA antagonist, AP5 (D,L-2-amino-5-phosphonopentanoic acid). In Expt. 1, spontaneous motor activity (locomotor activi...

journal_title：Brain research

authors： Kawabe K,Ichitani Y,Iwasaki T

更新日期：1998-01-19 00:00:00

abstract：:The dorsal column and its nuclei exhibit a considerable number of fibers containing neuropeptides, such as calcitonin gene-related peptide (CGRP) and substance P (SP), whose origins and functional roles are as yet unknown. The present study attempts to determine the origin and nature of these fibers by means of immuno...

journal_title：Brain research

authors： Tamatani M,Senba E,Tohyama M

更新日期：1989-08-21 00:00:00

abstract：:We examined the electrophysiological properties of cholinergic and non-cholinergic neurons in the medial septum-diagonal band complex (MSDB) of the rat in the in vitro slice preparation. Cells were identified electrophysiologically, filled with Lucifer yellow, fixed and processed for immunohistochemistry with fluoresc...

journal_title：Brain research

authors： Markram H,Segal M

更新日期：1990-04-09 00:00:00

abstract：:Pituitary adenylate cyclase-activating peptide (PACAP) is a 38-amino-acid polypeptide, first isolated from hypothalamus, which directly stimulates in vitro the production of cAMP as well as the release of several pituitary hormones, such as growth hormone and luteinizing hormone. In vivo, PACAP has been shown to stimu...

journal_title：Brain research

authors： Grinevich V,Fournier A,Pelletier G

更新日期：1997-10-31 00:00:00

abstract：:During a simple reaction time task using auditory or visual stimuli, a total of 96 single units were recorded from the dorsolateral prefrontal cortex of macaque monkeys. These monkeys were trained to depress a lever for a fixed period which produced a tone burst or a small spot of light. After a variable period, the s...

journal_title：Brain research

authors： Ito SI

更新日期：1982-09-09 00:00:00

abstract：:Cerebral vascular density is correlated with metabolic demands, which increase in highly active brain areas. External inputs are an essential requirement in the modeling of the visual cortex. Experience-mediated development is very active during the first postnatal month, when congruous blood supply is needed. We stud...

journal_title：Brain research

authors： Argandoña EG,Lafuente JV

更新日期：2000-02-07 00:00:00

abstract：:Intracerebroventricular administration into sedentary mice of the high molecular mass fraction of cerebrospinal fluid (CSF) from exercise-exhausted rats produced a decrease in spontaneous motor activity [K. Inoue, H. Yamazaki, Y. Manabe, C. Fukuda, T. Fushiki, Release of a substance that suppresses spontaneous motor a...

journal_title：Brain research

authors： Inoue K,Yamazaki H,Manabe Y,Fukuda C,Hanai K,Fushiki T

更新日期：1999-11-06 00:00:00

abstract：:We investigated the effect of Cerebrospinal Fluid (CSF) from sporadic Amyotrophic Lateral Sclerosis patients (SALS-CSF) on motor neuron-like cells to delineate the pathomechanism of SALS. Exposure of NSC-34 cells to SALS-CSF caused lower viability, reduction in differentiation and enhanced lactate dehydrogenase activi...

journal_title：Brain research

authors： Vijayalakshmi K,Alladi PA,Sathyaprabha TN,Subramaniam JR,Nalini A,Raju TR

更新日期：2009-03-31 00:00:00

abstract：:Ginseng, the root of Panax ginseng C.A. Meyer (Araliaceae), is a well known and popular herbal medicine used worldwide. Among more than 30 ginsenosides, the active ingredients of ginseng, ginsenosides Rb1 and Rg1 are regarded as the main compounds responsible for many pharmaceutical actions of ginseng. In our study, p...

journal_title：Brain research

authors： Radad K,Gille G,Moldzio R,Saito H,Rausch WD

更新日期：2004-09-17 00:00:00

abstract：:Growth hormone (GH) suppresses its own secretion by stimulating somatostatin (SRIF) release. Thus, the possible regulation of GH-releasing factor (GRF) and SRIF release and SRIF messenger ribonucleic acid (mRNA) by GH was studied in the hypothalamus of male rats in vitro. The median eminences (ME's) were incubated in ...

journal_title：Brain research

authors： Aguila MC,McCann SM

更新日期：1993-09-24 00:00:00

abstract：:It is now well known that dopamine (DA) receptors agonists can reduce striatal DA release. These compounds are generally thought to produce short-term effects. However, in a recent in vivo study we have reported that the D1/D2 receptor agonist apomorphine might induce decrements in striatal DA release that lasted seve...

journal_title：Brain research

authors： Abraini JH,Fechtali T,Rostain JC

更新日期：1994-04-11 00:00:00

abstract：:We have developed and tested the biological activity and specificity of a novel fluorescent dextran-Texas Red-nerve growth factor (DTR-NGF) conjugate. DTR-NGF was found to promote survival and neurite outgrowth in cultured dissociated sympathetic neurons similarly to native NGF. The conjugate was taken up and transpor...

journal_title：Brain research

authors： Gatzinsky KP,Haugland RP,Thrasivoulou C,Orike N,Budi-Santoso AW,Cowen T

更新日期：2001-11-30 00:00:00

abstract：:We previously reported that angiotensin II type 2 (AT(2)) receptor signaling prevents neural damage and cognitive impairment after focal cerebral ischemia. We investigated the possible roles of the AT(2) receptor in the sex difference, focusing on cognitive function and ischemic brain damage using AT(2) receptor-defic...

journal_title：Brain research

authors： Sakata A,Mogi M,Iwanami J,Tsukuda K,Min LJ,Fujita T,Iwai M,Ito M,Horiuchi M

更新日期：2009-12-01 00:00:00

abstract：:To investigate the role of the estrogen receptor (ER) in mediating neuroprotection, the neuroprotective profiles of selective ER agonists for ERalpha and ERbeta, propylpyrazole triol (PPT) and 2,3-bis(4-hydroxyphenyl) proprionitrile (DPN), respectively, were compared to that of 17beta-estradiol and 17alpha-estradiol i...

journal_title：Brain research

authors： Cordey M,Pike CJ

更新日期：2005-05-31 00:00:00

abstract：:The effects of undernutrition during pregnancy and/or lactation periods on cortical structures have already been reported. However, its effect on non-cortical areas like the hypothalamic, that participates in the regulation of the autonomic nervous system or food intake, has not been extensively investigated. We studi...

journal_title：Brain research

authors： González-Pardo H,Gutiérrez-Sánchez JM,Menéndez-Patterson A,Arias JL

更新日期：1994-08-15 00:00:00

abstract：:Recent pharmacological and morphological studies have raised the likelihood of a regulatory link between the neuropeptide Y (NPY) and beta-endorphin (beta-END) networks in the hypothalamus. To evaluate this link we have examined the effects of NPY administration on the in vivo release of beta-END by push-pull perfusio...

journal_title：Brain research

authors： Kalra PS,Norlin M,Kalra SP

更新日期：1995-12-24 00:00:00

abstract：:Status epilepticus is a life-threatening form of seizure activity that represents a major medical emergency associated with significant morbidity and mortality. Protein Kinase A is an important regulator of synaptic strength that may play an important role in the development of status epilepticus-induced neuronal path...

journal_title：Brain research

authors： Bracey JM,Kurz JE,Low B,Churn SB

更新日期：2009-08-04 00:00:00

abstract：:Gonadal steroids are thought to act by activation of the genome following cytoplasmic binding, translocation of the hormone--receptor complex to the nucleus and chromatin binding at specific acceptor sites. This study examined the kinetics of chromatin binding of estradiol by hypothalamic and cortical cells of adult g...

journal_title：Brain research

authors： Whalen RE,Olsen KL

更新日期：1978-08-18 00:00:00

abstract：:Flexion movements induced by cortical stimulation and the associated postural adjustments in bilaterally pyramidotomised cats have been studied by means of an apparatus which measures separately the changes of force under each limb in the upright position of the animal. The results show: (1) The general motor behaviou...

journal_title：Brain research

authors： Nieoullon A,Gahéry Y

更新日期：1978-06-23 00:00:00

abstract：:The effects of the epileptogenic agent, penicillin, on excitatory and inhibitory postsynaptic potentials (EPSPs and IPSPs) were studied in the hippocampal in vitro slice preparation. The actions of penicillin were compared to those of bicuculline, an antagonist of gamma-aminobutyric acid. Neither substance enhanced mo...

journal_title：Brain research

authors： Schwartzkroin PA,Prince DA

更新日期：1980-02-03 00:00:00