Abstract：
:The effects of undernutrition during pregnancy and/or lactation periods on cortical structures have already been reported. However, its effect on non-cortical areas like the hypothalamic, that participates in the regulation of the autonomic nervous system or food intake, has not been extensively investigated. We studied the postnatal development of the medial mammillary nucleus (hypothalamus) in the rat offspring that had a dietary restriction in utero and during lactation. The argyrophilic nucleolar regions (Ag-NORs), that represent the transcriptional activity of the cell, were quantified in their neurons. No statistically significant differences were found in the results between the control and undernourished groups in the ages studied (7, 14, 21 and 30 days). However, a delay in the neuronal activity of the latter group was observed. A critical period in the development of this nucleus, at about 21 days of age, was also seen in both groups. After this age, the activity levels remained steady.
journal_name
Brain Resjournal_title
Brain researchauthors
González-Pardo H,Gutiérrez-Sánchez JM,Menéndez-Patterson A,Arias JLdoi
10.1016/0006-8993(94)91572-5subject
Has Abstractpub_date
1994-08-15 00:00:00pages
75-80issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(94)91572-5journal_volume
654pub_type
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