当前位置： SCI文献检索 > BRAIN RESEARCH期刊下所有文献 > Release of angiotensin in the paraventricular nucleus in response to hyperosmotic stimulation in conscious rats: a microdialysis study.

Release of angiotensin in the paraventricular nucleus in response to hyperosmotic stimulation in conscious rats: a microdialysis study.

Abstract：

:Angiotensin peptides are thought to act as neurotransmitters or neuromodulators in central osmoregulation. We tested the hypothesis that angiotensin peptides are released in the paraventricular nucleus (PVN) of the hypothalamus upon local osmotic stimulation. Brain microdialysis and radioimmunoassay (RIA) techniques were used to measure the release of immunoreactive angiotensin II (irANG II) in the PVN following direct stimulation of this area with hyperosmotic solutions. In conscious rats, perfusion of the PVN with 0.3 M and 0.6 M NaCl in artificial cerebrospinal fluid (aCSF) elicited concentration-dependent increases in irANG II release to 5.52 +/- 0.53, (P < 0.01, n = 8) and 9.01 +/- 1.03 pg/100 microliters, (P < 0.001, n = 7), respectively, from basal values of 3.04 +/- 0.46 pg/100 microliters. Local perfusion of the PVN with 1.2 M glucose in aCSF also resulted in an increased release of irANG II from 3.07 +/- 0.87 to 6.24 +/- 0.45 pg/100 microliters (P < 0.05, n = 5). Fractionization of angiotensin peptides by HPLC followed by RIA revealed that ANG II (1-8) and ANG III (2-8) were released in similar amounts in the perfusate collected during 0.6 M NaCl stimulation (4.79 +/- 0.69 and 3.45 +/- 0.76 pg/100 microliters, respectively). Our results show that both, ANG II and ANG III are released in the PVN in response to local hyperosmotic stimulation. They support the concept that angiotensin peptides in the PVN are involved as neurotransmitters in central osmotic control.

journal_name

Brain Res

journal_title

Brain research

authors

Qadri F,Edling O,Wolf A,Gohlke P,Culman J,Unger T

doi

10.1016/0006-8993(94)91215-7

subject

Has Abstract

pub_date

1994-02-21 00:00:00

pages

45-9

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(94)91215-7

journal_volume

637

pub_type

杂志文章

相关文献

BRAIN RESEARCH文献大全
  • Serotonin increases the frequency of light-elicited discrete waves in type-B photoreceptors of Hermissenda.

    abstract：:Serotonin (5-HT) produces both short- and long-term enhancement of generator potentials in identified type B-photoreceptors of Hermissenda. The actions of 5-HT have been shown to modulate both light- and voltage-dependent conductances. To further examine light-dependent processes we studied spontaneous and light-elici...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(93)90969-t

    authors： Crow T,Pengidore T

    更新日期：1993-11-19 00:00:00

  • Behavioral effects of N-desmethylclozapine on locomotor activity and sensorimotor gating function in mice-Possible involvement of muscarinic receptors.

    abstract：:N-desmethylclozapine (NDMC), a major circulating metabolite of the atypical antipsychotic drug, clozapine, and has M(1) muscarinic receptor partial agonistic property. The purpose of the present study was to examine whether in vivo behavioral effects of NDMC were elicited through the activation of muscarinic receptors...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2011.08.056

    authors： Maehara S,Hikichi H,Ohta H

    更新日期：2011-10-18 00:00:00

  • Effects of kainic acid lesions in rat ventral lateral geniculate nucleus upon field potentials of the superior colliculus: correlation between morphological and physiological observations.

    abstract：:Morphological and physiological effects of kainic acid (KA) lesions in rat ventral lateral geniculate nucleus (LGV) were studied 1.5 and 6 h after KA injection. Morphological changes were examined mainly by electron micrographs. At 1.5 h after KA injection dendrites were dilated and some vacuolations occurred in both ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(89)90033-4

    authors： Nagata T,Tsukamoto Y,Matsuno K,Hayashi Y

    更新日期：1989-03-27 00:00:00

  • Immunocytochemical localization of corticotropin releasing factor (CRF) in the rat spinal cord.

    abstract：:The presence of corticotropin releasing factor (CRF)-immunoreactive nerve fibers and cell bodies in the spinal cord is demonstrated. Immunopositive fibers were found in the lateral column of the white matter, in laminae I, V-VII, X, and in the intermediolateral column of the spinal cord. Complete transection of the sp...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(83)91001-6

    authors： Merchenthaler I,Hynes MA,Vigh S,Shally AV,Petrusz P

    更新日期：1983-09-26 00:00:00

  • Injury to the nervous system: A look into the ER.

    abstract：:Injury to the central or peripheral nervous systems leads to the loss of cognitive and/or sensorimotor capabilities that still lack an effective treatment. Although injury to the nervous system involves multiple and complex molecular factors, alteration to protein homeostasis is emerging as a relevant pathological mec...

    journal_title：Brain research

    pub_type： 杂志文章,评审

    doi：10.1016/j.brainres.2016.04.053

    authors： Valenzuela V,Oñate M,Hetz C,Court FA

    更新日期：2016-10-01 00:00:00

  • Inhibition of corticosterone synthesis by Metyrapone decreases cocaine-induced locomotion and relapse of cocaine self-administration.

    abstract：:Several studies have recently shown that basal and stress-induced secretion of corticosterone may enhance vulnerability to drugs of abuse. In this report, we studied the effects of metyrapone, an inhibitor of the synthesis of corticosterone, on cocaine-induced locomotion and on the relapse of cocaine self-administrati...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(09)90034-8

    authors： Piazza PV,Marinelli M,Jodogne C,Deroche V,Rougé-Pont F,Maccari S,Le Moal M,Simon H

    更新日期：1994-09-26 00:00:00

  • Partial depletion of septohippocampal cholinergic cells reduces seizure susceptibility, but does not mitigate hippocampal neurodegeneration in the kainate model of epilepsy.

    abstract：:The brain cholinergic system may undergo structural and functional alterations both in human epilepsy and in respective animal models, but the causal relationships between these alterations and epilepsy remain to be established. In this study, we attempted to examine how the inhibition of epilepsy-related cholinergic ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2019.04.027

    authors： Soares JI,Da Costa C,Ferreira MH,Andrade PA,Maia GH,Lukoyanov NV

    更新日期：2019-08-15 00:00:00

  • Estrogen effects on tyrosine hydroxylase-immunoreactive cells in the ventral mesencephalon of the female rat: further evidence for the two cell hypothesis of dopamine function.

    abstract：:The present study was undertaken to examine the differential effect of estrogen (E) on the expression of tyrosine hydroxylase (TH) in the substantia nigra compacta (SNc) and in two subdivisions of the ventral tegmental area in ovariectomized (ovx) and ovx plus estradiol benzoate (ovx+E)-treated female rats. Cell count...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(00)02323-4

    authors： Zsarnovszky A,Scalise TJ,Horvath TL,Naftolin F

    更新日期：2000-06-23 00:00:00

  • Late post-learning participation of entorhinal cortex in memory processes.

    abstract：:Mice of the BALB/c strain were bilaterally implanted with electrodes in the lateral entorhinal cortex (EC) in order to study the influence of post-trial EC stimulation on memory. The learning task was a food reinforced operant conditioning. At one of several time intervals after a first learning session, the experimen...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(82)91201-x

    authors： Gauthier M,Destrade C,Soumireu-Mourat B

    更新日期：1982-02-11 00:00:00

  • Effects of phencyclidine administration on behavior and brain neurotensin-like immunoreactivity in rats.

    abstract：:The effects of acute and chronic phencyclidine (PCP) administration on neurotensin-like immunoreactivity (NTLI) were investigated in discrete regions of rat brain. Both acute and chronic administration of PCP induced high locomotor activity, stereotypy and ataxia. On PCP administration, NTLI decreased significantly in...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(85)91601-4

    authors： Wachi M,Okuda M,Togashi S,Fuwano S,Miyashita O

    更新日期：1985-05-06 00:00:00

  • Neurodynamics of an election.

    abstract：:Variables influencing decision-making in real settings, as in the case of voting decisions, are uncontrollable and in many times even unknown to the experimenter. In this case, the experimenter has to study the intention to decide (vote) as close as possible in time to the moment of the real decision (election day). H...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2010.06.046

    authors： da Rocha AF,Rocha FT,Burattini MN,Massad E

    更新日期：2010-09-10 00:00:00

  • Kinetics of potassium movement in norman cortex.

    abstract：:Artificial CSF containing 12mEq/1 of potassium (4 times normal concentration) was perfused over the surface of normal neocortex in 10 locally or barbiturate anesthetized cats. Extracellular potassium concentrations ([K+]OS) were measured as a function of time to 8 h and of depth to 3 mm. Analysis of the [K+]O versus d...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(76)90265-1

    authors： Fisher RS,Pedley TA,Prince DA

    更新日期：1976-01-16 00:00:00

  • Contribution of plasma membrane and endoplasmic reticulum Ca(2+)-ATPases to the synaptosomal [Ca2+]i increase during oxidative stress.

    abstract：:In the present study we analyzed the effect of ascorbate (0.8 mM)/Fe2+ (2.5 microM)-induced membrane lipid peroxidation on the levels of intracellular free calcium,[Ca2+]i and on the possible mechanisms involved in the perturbation of intracellular calcium homeostasis during oxidative stress. For this purpose, the inf...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(95)01554-x

    authors： Pereira C,Ferreira C,Carvalho C,Oliveira C

    更新日期：1996-03-25 00:00:00

  • LM and EM immunolocalization of the gap junctional protein connexin 43 in rat brain.

    abstract：:A site-specific antibody against the principal gap junctional protein in heart (connexin 43) was used to determine immunohistochemically the cellular localization of this protein in rat brain. Structures labelled with the antibody included gap junctional membranes between glial, ependymal, pial and arachnoid cells as ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(90)90415-8

    authors： Yamamoto T,Ochalski A,Hertzberg EL,Nagy JI

    更新日期：1990-02-05 00:00:00

  • MP-124, a novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor, ameliorates ischemic brain damage in a non-human primate model.

    abstract：:Overactivation of poly (ADP-ribose) polymerase-1 (PARP-1) in response to DNA damage is considered to play a crucial role in the development of post-ischemic neuronal injury, such as ischemic stroke. The present study was undertaken to clarify the beneficial effects of MP-124, a novel PARP-1 inhibitor, on neurological ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2011.05.069

    authors： Matsuura S,Egi Y,Yuki S,Horikawa T,Satoh H,Akira T

    更新日期：2011-09-02 00:00:00

  • Loss of benefit from estrogen replacement therapy in diabetic ovariectomized female rats subjected to transient forebrain ischemia.

    abstract：:In nondiabetic animals, estrogen has been shown to provide significant neuroprotection in focal and transient forebrain ischemia models. However, that neuroprotection may be diminished or lost in the diabetic. In this study, we compared the level of brain damage in intact, ovariectomized (OVX) and 17beta-estradiol (E(...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(02)03484-4

    authors： Santizo RA,Xu HL,Ye S,Baughman VL,Pelligrino DA

    更新日期：2002-11-22 00:00:00

  • Effect of postnatal light deprivation on the ontogenesis of dopamine neurons in rat retina.

    abstract：:In rats raised from birth under a regular dark-light cycle, retinal dopamine (DA) levels were low at 12 days, increased progressively and steeply at 16, 20, 30 and 60 days and peaked at about 75 days postnatally. Dark-rearing from birth suppressed the magnitude of the normal developmental pattern of DA concentrations ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0165-3806(86)90293-2

    authors： Melamed E,Frucht Y,Vidauri J,Uzzan A,Rosenthal J

    更新日期：1986-05-01 00:00:00

  • The relationship between white matter brain metabolites and cognition in normal aging: the GENIE study.

    abstract：:Magnetic resonance spectroscopy (MRS) has demonstrated age-related changes in brain metabolites that may underlie micro-structural brain changes, but few studies have examined their relationship with cognitive decline. We performed a cross-sectional study of brain metabolism and cognitive function in 82 healthy adults...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2007.06.027

    authors： Charlton RA,McIntyre DJ,Howe FA,Morris RG,Markus HS

    更新日期：2007-08-20 00:00:00

  • The vermal projection of spinocerebellar tracts arising from lower cervical segments in the cat: an anterograde WGA-HRP study.

    abstract：:Following injections of WGA-HRP into lower cervical segments, the distribution of anterograde labeled terminals of spinocerebellar fibers was examined in the vermal cortex of the cat. The labeled terminals were seen in sublobules Ib to VIc, VIIb, VIIIa and VIIIb, and lobule IX. They were present mainly in the medial p...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(85)91261-2

    authors： Matsushita M,Ikeda M,Tanami T

    更新日期：1985-12-23 00:00:00

  • Chronic intracerebral infusions of vasopressin and vasopressin antagonist modulate social recognition in rat.

    abstract：:To assess the role of androgen-dependent brain vasopressinergic transmission in the modulation of social recognition, castrated male rats which are deficient in vasopressin were implanted intracerebroventricularly with an Accurel collodion mini-device containing 10 micrograms vasopressin (AVP) whereas intact male rats...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(92)90480-w

    authors： Bluthé RM,Dantzer R

    更新日期：1992-02-14 00:00:00

  • Quantitative study of the distribution of lithium in the mouse brain for various doses of lithium given to the animal.

    abstract：:Lithium is detected in the mouse brain with the aid of a (n,alpha) nuclear reaction. The resolving power is of a few micron. The detection efficiency is estimated in a first series of experiments with brain sections of progressively increasing thickness. This allows us to make the microlocation of lithium in the brain...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(80)90239-5

    authors： Thellier M,Heurteaux C,Wissocq JC

    更新日期：1980-10-13 00:00:00

  • 5-HT3-like receptors in the rat medial prefrontal cortex: an electrophysiological study.

    abstract：:In this study, we have identified and characterized 5-HT3-like receptors in the rat medial prefrontal cortex (mPFc), an area with a moderate density of 5-HT3 binding sites, using the techniques of single unit recording and microiontophoresis. The microiontophoresis of the 5-HT3 receptor agonist 2-methylserotonin (2-Me...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(91)91316-s

    authors： Ashby CR Jr,Minabe Y,Edwards E,Wang RY

    更新日期：1991-06-07 00:00:00

  • Optical responses evoked by white matter stimulation in rat visual cortical slices and their relation to neural activities.

    abstract：:To characterize optical responses (ORs) evoked by white matter (WM) stimulation in slices of rat visual cortex (VC) stained with voltage sensitive dyes, time course of ORs in each layer was investigated by recording ORs with a linearly aligned photodiode array, and the spatial patterns of the ORs at specified time aft...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(96)00767-6

    authors： Tanifuji M,Yamanaka A,Sunaba R,Terakawa S,Toyama K

    更新日期：1996-10-28 00:00:00

  • Proportion of unmyelinated axons in the rat inferior alveolar nerve and mandibular molar pulps after neonatal administration of capsaicin.

    abstract：:Neonatal rats were given capsaicin subcutaneously. Controls received vehicle only. Six months later the nerve fiber populations in the dorsal root L4, in the inferior alveolar nerve and in mandibular molar pulps were examined by electron microscopy. The proportion of unmyelinated axons was found to be markedly decreas...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(83)91315-x

    authors： Holje L,Hildebrand C,Fried K

    更新日期：1983-04-25 00:00:00

  • The central and peripheral ends of the substance P-containing sensory neurones in the rat trigeminal system.

    abstract：:The distribution of substance P (SP) immunoreactivity in the spinal nucleus of the rat trigeminal nerve and in the skin of the lower lip was examined following (a) unilateral electrolytic lesions of the trigeminal ganglion, (b) trigeminal rhizotomy, and (c) unilateral interruption of the mental nerve, the sensory bran...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(78)91105-8

    authors： Cuello AC,Del Fiacco M,Paxinos G

    更新日期：1978-09-08 00:00:00

  • Short-latency excitation of phrenic motor output mediated by non-NMDA receptors.

    abstract：:This study tested the hypothesis that the short-latency excitation of the phrenic motor output elicited by superior laryngeal nerve (SLN) stimulation requires non-NMDA receptor-mediated neurotransmission in the region of the dorsal respiratory group (DRG) of the adult cat. Injection of the non-NMDA receptor antagonist...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(95)00355-t

    authors： Karius DR,Speck DF

    更新日期：1995-06-05 00:00:00

  • Interaction between spontaneous and electrically induced convulsions and their short- and long-term effects in the abstinence after chronic barbital treatment in the rat.

    abstract：:Male rats were treated with barbital supplied in their drinking water (daily dose around 200 mg/kg) for 50 weeks. When the treatment was stopped (day 0) spontaneous convulsions were monitored for the first 3 days of the abstinence. On day 3 a convulsion was induced by electricity in half of the rats (controls and barb...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(83)90653-4

    authors： Wahlström G

    更新日期：1983-05-05 00:00:00

  • Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120.

    abstract：:Astrocytes and microglia in the spinal cord have recently been reported to contribute to the development of peripheral inflammation-induced exaggerated pain states. Both lowering of thermal pain threshold (thermal hyperalgesia) and lowering of response threshold to light tactile stimuli (mechanical allodynia) have bee...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(00)02050-3

    authors： Milligan ED,Mehmert KK,Hinde JL,Harvey LO,Martin D,Tracey KJ,Maier SF,Watkins LR

    更新日期：2000-04-07 00:00:00

  • Development of receptive field properties in the visual cortex of rabbits subjected to early epileptiform cortical discharges.

    abstract：:We examined the effects of early epileptiform activity on development of visuocortical receptive fields in the rabbit. Aqueous penicillin was injected twice a day into a cannula implanted over the monocular area of one visual cortex. Drug administration was begun on postnatal day 8-9 and continued until postnatal day ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0165-3806(81)90113-9

    authors： Crabtree JW,Chow KL,Ostrach LH,Baumbach HD

    更新日期：1981-04-01 00:00:00

  • Pattern of fos activation in the ventral tegmental area (VTA) of male prairie vole's (Microtus ochrogaster) in response to infant-related stimuli.

    abstract：:Prairie voles are socially monogamous mammals that form pair bonds and display paternal care. This study was focused on the male prairie vole's neuronal responses to infant-related odors. Using the fos protein as a measure of neuronal activation, we examined the brain responses of males to infant-related odors. Prior ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2019.02.023

    authors： Lang DY,Bamshad M,Dorcely R

    更新日期：2019-07-01 00:00:00