Abstract:
:To assess the role of androgen-dependent brain vasopressinergic transmission in the modulation of social recognition, castrated male rats which are deficient in vasopressin were implanted intracerebroventricularly with an Accurel collodion mini-device containing 10 micrograms vasopressin (AVP) whereas intact male rats were implanted with a similar device containing 50 micrograms of 1-deaminopenicillamine 2-O-methyltyrosine arginine vasopressin (dPTyr(Me)AVP), a specific antagonist of the vasopressor like receptors of vasopressin. Control rats in each experimental group were implanted with an Accurel device containing water. Castrated rats treated with AVP explored familiar juvenile conspecifics in the same manner as intact male rats. Conversely, intact male rats treated with dPTyr(Me)AVP explored familiar juveniles in the same manner as castrated male rats. These results confirm the role of androgen-dependent vasopressinergic neurotransmission in social recognition.
journal_name
Brain Resjournal_title
Brain researchauthors
Bluthé RM,Dantzer Rdoi
10.1016/0006-8993(92)90480-wsubject
Has Abstractpub_date
1992-02-14 00:00:00pages
261-4issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(92)90480-Wjournal_volume
572pub_type
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