Kinetics of potassium movement in norman cortex.

abstract：:Anesthetized Sprague-Dawley rats fitted with intracerebroventricular (i.c.v.) cannulas were infused with one of the aminopeptidase inhibitors, amastatin or bestatin, over a 5-min period. After infusion, 1-2 X 10(6) cpm of [125I]angiotensin II ([125I]AII) or [125I]angiotensin III ([125I]AIII) was injected through the s...

journal_title：Brain research

authors： Dewey AL,Wright JW,Hanesworth JM,Harding JW

更新日期：1988-05-17 00:00:00

abstract：:This paper describes an electrochemical method for the detection of dopamine and serotonin in vitro. Dopamine and serotonin can be distinguished from each other without interference from metabolites. 3-4-dihydroxyphenylacetic acid and 5-hydroxyindoleacetic acid. The method also provides selective differentiation of do...

journal_title：Brain research

authors： Broderick PA

更新日期：1989-08-21 00:00:00

abstract：:The effect of the non-competitive N-methyl-D-aspartate antagonist MK-801 on the early development of kindling-induced potentiation was examined in the rabbit hippocampal dentate gyrus. MK-801 (0.5 mg/kg) was administered 2 h before each daily kindling stimulation was applied to the perforant path. This treatment conti...

journal_title：Brain research

authors： Robinson GB

更新日期：1991-10-18 00:00:00

abstract：:Rats were administered haloperidol (0.5 mg/kg/day) for 21 days. Twenty percent of locus coeruleus (LC) neurons recorded were not spontaneously active, while no such neuron was observed in control animals. A further 22% of neurons (spontaneously active) had rates greater than 2 standard deviations from the mean of LC c...

journal_title：Brain research

authors： Dinan TG,Aston-Jones G

更新日期：1985-01-28 00:00:00

abstract：:Intracellular recordings were obtained from CA1 pyramidal neurons in obliquely cut in vitro hippocampal slices. Recurrent IPSPs were elicited by antidromic stimulation of alvear fibers. The mechanisms by which IPSPs depress pyramidal cell excitability were investigated. Recurrent IPSPs could be reversed in sign by sma...

journal_title：Brain research

authors： Dingledine R,Langmoen IA

更新日期：1980-03-10 00:00:00

abstract：:Cognitive impairment is a prevalent non-motor feature of Parkinson's disease (PD) which can present even in early stages of the disease. Impairments in executive processing and working memory (WM) are common and have been attributed, in part, to abnormalities within the dorsolateral prefrontal cortex (DLPFC) and broad...

journal_title：Brain research

authors： Hill AT,McModie S,Fung W,Hoy KE,Chung SW,Bertram KL

更新日期：2020-01-01 00:00:00

abstract：:We investigated c-Met expression in cultured astrocytes and their regulation by cytokines. Immunocytochemistry revealed that c-Met was expressed in cultured astrocytes. Western blotting revealed that acidic and basic fibroblast growth factor (FGF) enhanced and hepatocyte growth factor (HGF) reduced c-Met expression. R...

journal_title：Brain research

authors： Shimazaki K,Yoshida K,Hirose Y,Ishimori H,Katayama M,Kawase T

更新日期：2003-02-07 00:00:00

abstract：:Dissociated Muller (glial) cells from the neotenous tiger salamander retina respond electrogenically and rheogenically to three putative catecholamine (CA) neurotransmitters, epinephrine, norepinephrine and dopamine. All 3 CAs stimulate a net inward current and an increase in input resistance (Rn). The Muller cell res...

journal_title：Brain research

authors： Henshel DS,Miller RF

更新日期：1992-03-20 00:00:00

abstract：:The implantation of dopamine-rich mesencephalic grafts into the 6-hydroxydopamine (6-OHDA)-lesioned neostriatum of rats was accompanied by marked hyperinnervation by serotonin (5-HT) fibers. The purpose of this study was to examine the possibility that the graft-derived 5-HT hyperinnervation is governed by target-rela...

journal_title：Brain research

authors： Takeuchi Y,Sawada T,Blunt S,Jenner P,Marsden CD

更新日期：1992-10-02 00:00:00

abstract：:Swelling of glial and nerve cells is characteristic of brain damage in cerebral ischemia or trauma. The therapeutical efficiency of inhibition of Cl(-)-transport by a novel antagonist, the diuretic torasemide, on cytotoxic swelling of glial cells from lactacidosis, or glutamate was analyzed. Lactacidosis and the inter...

journal_title：Brain research

authors： Staub F,Peters J,Kempski O,Schneider GH,Schürer L,Baethmann A

更新日期：1993-04-30 00:00:00

abstract：:As an approach to understanding why central neurons fail to regenerate, we have studied the response to proximal axotomy of transcallosal neurons of the cerebral cortex of the mouse. Anatomical studies have indicated only very slight regenerative responses by this population of cortical neurons. To further examine the...

journal_title：Brain research

authors： Elliott EJ,Parks DA,Fishman PS

更新日期：1997-05-02 00:00:00

abstract：:In rats with unilateral 6-hydroxydopamine lesions of the substantia nigra, a specific D1 dopamine receptor agonist, SKF 38393A, at a dose that does not itself produce turning, significantly increased the contralateral rotation observed following a low dose of the specific D2 agonist LY 171555. Doses of SKF 38393A or t...

journal_title：Brain research

authors： Robertson GS,Robertson HA

更新日期：1986-10-08 00:00:00

abstract：:Previous research has demonstrated that diabetes induces learning and memory deficits. However, the mechanism of memory impairment induced by diabetes is poorly understood. The present study investigated the effect of streptozotocin (STZ)-induced diabetes on spatial learning and memory using the Morris Water Maze. The...

journal_title：Brain research

authors： Ye L,Wang F,Yang RH

更新日期：2011-09-09 00:00:00

abstract：:Little is known about the movement of 5-aminolevulinic acid (delta-aminolevulinic acid; ALA) between blood and brain. This is despite the fact that increases in brain ALA may be involved in generating the neuropsychiatric symptoms in porphyrias and that systemic administration of ALA is currently being used to delinea...

journal_title：Brain research

authors： Ennis SR,Novotny A,Xiang J,Shakui P,Masada T,Stummer W,Smith DE,Keep RF

更新日期：2003-01-10 00:00:00

abstract：:The effects of pituitary adenylate cyclase activating polypeptides (PACAPs: PACAP27, PACAP38) on glutamate-induced neurotoxicity were examined using cultured retinal neurons obtained from 3- to 5-day old Wistar rats. Cell viability was evaluated by double staining with fluorescein diacetate and propidium iodide. Effec...

journal_title：Brain research

authors： Shoge K,Mishima HK,Saitoh T,Ishihara K,Tamura Y,Shiomi H,Sasa M

更新日期：1999-08-21 00:00:00

abstract：:Production of inflammatory cytokines, including tumor necrosis factor (TNF), interleukin-1 (IL-1) and interleukin-6 (IL-6), in the brain is increased in various diseases. To investigate the relationships between the effect of overproduction of IL-6 in the brain on central and peripheral production of TNF, IL-1 beta an...

journal_title：Brain research

authors： Di Santo E,Alonzi T,Fattori E,Poli V,Ciliberto G,Sironi M,Gnocchi P,Ricciardi-Castagnoli P,Ghezzi P

更新日期：1996-11-18 00:00:00

abstract：:Effects of taurine on endogenous aspartic acid (Asp), glutamic acid (Glu) and gamma-aminobutyric acid (GABA) release has been investigated using synaptosomes prepared from rat cerebral cortex. Although basal release of these amino acids was not affected, taurine inhibited KCl (30 mM)-evoked overflow of Asp, Glu and GA...

journal_title：Brain research

authors： Kamisaki Y,Maeda K,Ishimura M,Omura H,Itoh T

更新日期：1993-11-12 00:00:00

abstract：:The effects of diethyldithiocarbamate (DDC) and DDC plus glutamate on mesencephalic cell cultures were investigated. DDC 10 microM was toxic for cell cultures as assessed by observation under a phase-contrast microscope and the drop in [3H]dopamine uptake. Moreover, DDC 1 microM greatly potentiated cell death induced ...

journal_title：Brain research

authors： Vaglini F,Pardini C,Maggio R,Corsini GU

更新日期：1995-03-13 00:00:00

abstract：:Ventilation is peripherally controlled by afferent activity arising from the peripheral chemoreceptors. In the rat, chemosensory activity is conveyed to the central nervous system through axons of neurons located in the nodose-petrosal-jugular-complex. These neurons have distinct electrophysiological properties, inclu...

journal_title：Brain research

authors： Alcayaga J,Oyarce MP,Del Rio R

更新日期：2016-10-15 00:00:00

abstract：:Possible involvement of the amygdaloid input in long-term potentiation (LTP) in the medial perforant path-dentate gyrus granule cell synapses in vivo was investigated by evaluating the effects of lesions of the amygdaloid nucleus. The dentate gyrus synaptic potential evoked by low-frequency test stimulation did not ch...

journal_title：Brain research

authors： Ikegaya Y,Saito H,Abe K

更新日期：1994-09-05 00:00:00

abstract：:Behavioral studies have shown that the hyperalgesia arising from inflammatory agents, such as prostaglandin E(2) (PGE(2)), can be antagonized by activators of the ATP-sensitive potassium current (K(ATP)). This observation raises questions as to whether this suppression results from a direct action on sensory neurons a...

journal_title：Brain research

authors： Chi XX,Jiang X,Nicol GD

更新日期：2007-05-11 00:00:00

abstract：:Injection of inositol 1,4,5-trisphosphate (InsP3) into dark-adapted Limulus ventral photoreceptors produces a series of discrete bursts of membrane depolarization. Prior injection of aequorin, a luminescent calcium indicator, reveals that the bursts of depolarization are accompanied by individual bursts of intracellul...

journal_title：Brain research

authors： Corson DW,Fein A

更新日期：1987-10-13 00:00:00

abstract：:The effects of diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), on the fast tetrodotoxin-sensitive (TTX-S) and the slow tetrodotoxin-resistant (TTX-R) sodium currents in rat dorsal root ganglion neurons were investigated using the whole-cell patch-clamp method. Diclofenac suppressed both sodium currents in a...

journal_title：Brain research

authors： Lee HM,Kim HI,Shin YK,Lee CS,Park M,Song JH

更新日期：2003-11-28 00:00:00

abstract：:To test the hypothesis that enkephalins, substance P, bradykinin and angiotensin II could act as neurohumoral modulators of hypothalamic function, these peptides (0.01-20 microgram) were injected into the general circulation of anesthetized rats, and changes in hypothalamo-neurohypophysial activity were determined by ...

journal_title：Brain research

authors： Baertschi AJ,Zingg HH,Dreifuss JJ

更新日期：1981-09-07 00:00:00

abstract：:Rats predisposed to develop diet-induced obesity (DIO) preferentially activate their sympathetic nervous system during intracarotid glucose infusion [B.E. Levin, Intracarotid glucose-induced norepinephrine response and the development of diet-induced obesity, Int. J. Obesity 16 (1992) 451-457.] but their brains are ge...

journal_title：Brain research

authors： Levin BE,Govek EK,Dunn-Meynell AA

更新日期：1998-10-19 00:00:00

abstract：:The present study examined the behavioral effects of dopamine receptor agonists, antagonists, or N-methyl-D-aspartate (NMDA) glutamate receptor antagonist in rats with a unilateral excitotoxic lesion of the globus pallidus (GP). After the unilateral GP lesions were made by injections of the ibotenic acid, drugs were s...

journal_title：Brain research

authors： Miwa H,Nishi K,Fuwa T,Mizuno Y

更新日期：1998-01-19 00:00:00

abstract：:Acute administration of diazepam (2 mg/kg i.p.) to rats decreased the number of head-dips, locomotor activity and the number of rears made in the holeboard apparatus, indicating sedative effects. After daily treatment for 7 days with diazepam (2 mg/kg) tolerance developed to all these behavioural effects, despite seru...

journal_title：Brain research

authors： Fernandes C,File SE,Berry D

更新日期：1996-09-23 00:00:00

abstract：:Given a hypothesised role for CCK in the anterior cingulate cortex (ACC) for the sensation of pain, the aim of the present study was to investigate whether the increased CCK release could be affected by two different analgesic drugs, morphine and the non-selective cyclooxygenase inhibitor diclofenac. Since opioids sti...

journal_title：Brain research

authors： Heilborn U,Rost BR,Arborelius L,Brodin E

更新日期：2007-03-09 00:00:00

abstract：:Isolated neuronal cells dissociated from the brain of embryonic rabbits on the sixteenth day of gestation and of perinatal rats (eighteenth embryonic day, to E18, thirteenth day postnatum, p.n. 13) were selectively cultured using a plasma clot technique. The cells grown were shown to be neurons by means of the neuron-...

journal_title：Brain research

authors： Buse E,Matthaei H

更新日期：1983-04-01 00:00:00

abstract：:Current responses to acetylcholine (ACh) and to suberyldicholine (D-6) applied from the double-barrelled ionophoretic micropipette were studied in two identified neurones (LPed-2 and LPed-3) isolated from the left ganglion of pulmonate mollusc, Planorbarius corneus. Experiments made with K2SO4-filled microelectrodes s...

journal_title：Brain research

authors： Katchman AN,Zeimal EV

更新日期：1982-06-03 00:00:00