Abstract:
:Current responses to acetylcholine (ACh) and to suberyldicholine (D-6) applied from the double-barrelled ionophoretic micropipette were studied in two identified neurones (LPed-2 and LPed-3) isolated from the left ganglion of pulmonate mollusc, Planorbarius corneus. Experiments made with K2SO4-filled microelectrodes show that in LPed-2 neurone two kinds of cholinoreceptors are involved in the rapid phase of ACh response one of which induces chloride conductance and the other, sodium conductance. The Cl-dependent component can be separated from the cationic one by C-6 whereas the cationic component can be separated from the Cl--dependent one by furosemide. Cl- conductance can be induced selectively by D-6. In the LPed-3 neurone only Cl- conductance increases during rapid phase of ACh response. The reversal potential of Cl--dependent responses was found to be more negative than the resting potential in experiments made with K2SO4-filled microelectrodes but less negative than the resting potential in the case of KCl-filled microelectrodes. This difference seems to be due to the artificial increase of intracellular chloride concentration.
journal_name
Brain Resjournal_title
Brain researchauthors
Katchman AN,Zeimal EVdoi
10.1016/0006-8993(82)91232-xsubject
Has Abstractpub_date
1982-06-03 00:00:00pages
95-103issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(82)91232-Xjournal_volume
241pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The effects of alpha-bungarotoxin from Bungarus multicinctus and Bungarus caeruleus were studied on three types of cholinergic response in Aplysia central neurones. These responses are the result of three distinct changes in ionic permeability: selective increases in permeabiliyt to Na, Cl and K, respectively. It was ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90142-6
更新日期:1976-05-14 00:00:00
abstract::The ultrastructural morphology and synaptic associations between enkephalin-containing neurons and sensory afferents was examined in the caudalis portion of rat spinal trigeminal complex, the region corresponding to Rexed's layer II of the dorsal horn. Specific antiserum to Met5-enkephalin was localized by the peroxid...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90580-7
更新日期:1982-09-30 00:00:00
abstract::The present experiments showed that there is a cortico-thalamo-cortical projection system in the cat, which originates from the primary visual cortex, relayed by the lateral part of the lateral posterior nucleus of the thalamus, and reaching the medial bank of the lateral suprasylvian visual area. This finding suggest...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90323-4
更新日期:1990-02-12 00:00:00
abstract::The administration of alpha 2-adrenoreceptor antagonists SKF 64139 or SKF 72223 (TIQ derivatives) elicits an increase in striatal DOPA synthesis. The findings that the enhanced DOPA synthesis is reversed by pretreatment of the animals with clonidine or with the D beta H inhibitor FLA-63 suggest that action of the TIQ ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90427-3
更新日期:1981-12-28 00:00:00
abstract::Synaptic activation of the neurosecretory cells within the glandular lobe of the corpus cardiacum of locusts results in the release of bioassayable adipokinetic hormones and an elevation in cAMP. The effectiveness of several putative aminergic neurotransmitters in mimicking these actions of the natural transmitter, an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90116-6
更新日期:1983-12-12 00:00:00
abstract::We have examined, at the light microscope level, putative direct synaptic interconnections, via motor axon collaterals, between type-identified triceps surae alpha-motoneurons labeled by intracellular injection of HRP. The results indicate that monosynaptic recurrent contacts can occur between synergist motoneurons (i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90937-5
更新日期:1984-08-06 00:00:00
abstract::Horseradish peroxidase was injected intracellularly into motoneurons responding to cutaneous stimulation of the central foot pad of the hind limb in cats. Three motoneurons were selected for detailed analysis: two excited by foot pad stimulation, and one postsynaptically inhibited by such stimulation. The overall leng...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90669-2
更新日期:1982-12-16 00:00:00
abstract::We previously showed indirectly that the increase in diacylglycerol (DAG) levels caused by exposing differentiating PC12 cells to nerve growth factor (NGF) must derive mainly from de novo synthesis and, to a lesser and transient extent, from the hydrolysis of [3H]phosphatidylinositol (PI). To explore further the bioch...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01280-3
更新日期:1999-02-13 00:00:00
abstract::Astrocytes associated with beta-amyloid (Aβ)-deposited senile plaques are a common neuropathological feature of Alzheimer's disease (AD). There is little doubt that the association of Aβ with the major component in the central nervous system cells significantly influences disease progression, however, the molecular me...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.12.062
更新日期:2012-03-02 00:00:00
abstract::The effect of bilateral lesion of the accessory olfactory bulb (AOB) on the mating-induced enhancement of sexual receptivity was investigated in ovariectomized (OVX) female rats. Lesions of the AOB significantly reduced the lordosis-to-mount (L/M) ratio in mating tests conducted 20 to 50 days after the lesion but L/M ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90902-4
更新日期:1994-04-11 00:00:00
abstract::The effect of aging on the properties of N-methyl-D-aspartate (NMDA) receptors in the forebrain of female NMRI mice was investigated using the antagonist [3H]MK-801 as radioligand. Compared to young (3 months) mice, aged (20 months) mice showed changes of the properties of the NMDA receptor at three different levels: ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90892-d
更新日期:1992-07-03 00:00:00
abstract::Tissue damage induces acute pain but also long-term central modifications that can affect the behavioral and neuronal responses to a second painful stimulus. To study the effects of female gonadal hormones on the responses to repetition of a nociceptive stimulus, we subjected adult female rats to the formalin test. Th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.05.089
更新日期:2006-08-23 00:00:00
abstract::Systemic administration of the protein synthesis inhibitor, cycloheximide, induced both phase advances and phase delays in the circadian rhythm of wheel-running activity in hamsters (Mesocricetus auratus) maintained in constant darkness or constant light. The magnitude and direction of the phase shifts were dependent ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91053-6
更新日期:1989-09-04 00:00:00
abstract::Nociceptin/orphanin FQ is an endogenous neuropeptide that plays important roles in several physiological functions including pain, anxiety, locomotion, learning, and memory. We previously reported that low doses of nociceptin improved the scopolamine-induced impairment of learning and memory in the passive avoidance t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.12.008
更新日期:2008-02-21 00:00:00
abstract::The pedunculopontine nucleus (PPN), the cholinergic arm of the reticular activating system (RAS), is known to modulate waking and rapid eye movement (REM) sleep. REM sleep decreases between 10 and 30 days postnatally in the rat, with the majority occurring between 12 and 21 days. We investigated the possibility that c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.10.046
更新日期:2007-01-19 00:00:00
abstract::The sympathetic preganglionic neurons in the spinal cord receive dense serotonergic (5-HT) and catecholaminergic (CA) afferent inputs from the descending supraspinal pathways. In the rat spinal cord, the levels of these biogenic amines and their receptors are low at birth, but undergo rapid ontogenetic increases in th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(85)90231-7
更新日期:1985-03-01 00:00:00
abstract::The protective effect of mild hypothermia was studied in rodent models of both permanent and transient focal cerebral ischemia. In Expt. 1, Wistar rats were exposed to 6 h permanent ischemia by bilateral occlusion of both common carotid arteries and right middle cerebral artery. In Expt. 2, animals were exposed to 3 h...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91428-h
更新日期:1992-07-31 00:00:00
abstract::In vitro evidence indicates that norepinephrine release in the mammalian hippocampus is modulated by glutamate receptors. With the use of microdialysis, we have now evaluated the role of ionotropic glutamate receptors in the regulation of hippocampal norepinephrine output in vivo. Stimulation of N-methyl-D-aspartate (...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.02.065
更新日期:2011-04-22 00:00:00
abstract::Studies with radioactive antipyrene and deoxyglucose indicated that both blood flow and metabolism are enhanced in the goldfish optic tectum following a brief visual stimulation. It is concluded that the brain of cold-blooded animals demonstrates regionally regulated physiological alterations, previously reported only...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90195-1
更新日期:1979-01-26 00:00:00
abstract::Zinc ions seem to be important to several neurological functions and have been connected to the pathophysiology of epilepsy, neuronal cell death after seizure or stroke, and Alzheimer's disease. Both epilepsy and Alzheimer's disease are clinical conditions believed to involve the olfactory bulb. The mammalian olfactor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03544-8
更新日期:2002-11-29 00:00:00
abstract::We have previously used organotypic cultures to study mechanisms regulating phenotypic expression of neurotransmitter characters in the brain. Our previous work indicated that nerve growth factor (NGF) specifically increased the activity of choline acetyltransferase (CAT) in striatal cholinergic interneurons. In the p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91136-x
更新日期:1987-06-02 00:00:00
abstract::We observed temporal changes in NACP (precursor protein of non-Abeta component of Alzheimer's disease amyloid), a presynaptic protein a.k. a. alpha-synuclein, in the hippocampus after 5 min ischemia. Intense NACP immunoreactivity was seen transiently around cerebral blood vessels in the CA1 subfield on day 4, and NACP...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00033-x
更新日期:1998-03-30 00:00:00
abstract::Seventy-nine single units were recorded with glass micropipettes applied onto taste pores of the anterior portion of the tongue in anesthetized hamsters. The receptive field of each recorded unit was located by iontophoretic stimulation applying either anodal or cathodal current (1-20 microA) to a non-stimulating solu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90643-P
更新日期:1990-04-02 00:00:00
abstract::The optic nerve of anesthetized cats was completely cut and the autologous sciatic nerve was transplanted. Sixty days later some populations of retinal ganglion cells were shown to regenerate the axon with retrograde HRP labeling. We verified that ganglion cells that had projected to the lateral geniculate nucleus (LG...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91253-w
更新日期:1991-09-27 00:00:00
abstract::Endogenous long-duration burst-organizing potentials (driver potentials, DPs) generated by neurons in the lobster cardiac ganglion play a critical role in the ability of the system to generate rhythmic bursts of nerve impulses. The DPs are normally terminated by a voltage-dependent potassium current, but when this is ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90854-g
更新日期:1993-04-23 00:00:00
abstract::Kappa opioid receptors (KORs) were immunocytochemically localized at four different levels of the spinal cord of normally-cycling female rats in estrus or diestrus. KOR labeling was primarily observed in fine processes and a few neuronal cell bodies in the superficial dorsal horn and the dorsolateral funiculus. Quanti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02515-x
更新日期:2001-06-29 00:00:00
abstract::The main purpose of the present study was to determine whether specific regions of the mouse brain exhibit different age-related changes in oxidative stress, as indicated by glutathione redox state and the level of protein-glutathionyl mixed disulfides. Comparison of 3- and 21-month-old mice indicated an age-related d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.10.040
更新日期:2007-01-05 00:00:00
abstract:BACKGROUND:Intermittent hypoxia during sleep (IH), as occurs in sleep disordered breathing (SDB), induces spatial learning deficits associated with regulation of transcription factors associated with learning and memory in the hippocampal CA1 region in rats. high fat refined carbohydrate diet (HF/RC) can induce similar...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.03.046
更新日期:2006-05-23 00:00:00
abstract::The effects of the imidazothienodiazepinone Ro 19-4603 were investigated in mice. Ro 19-4603 (0.03-0.3 mg/kg) caused a dose-related reduction in seizure threshold to i.v. bicuculline. Doses of 0.1-3 mg/kg induced seizures in some but not all mice, consistent with its suggested action as a partial benzodiazepine recept...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90551-9
更新日期:1989-03-13 00:00:00
abstract::Astrocytes provide structural, trophic and metabolic support to neurons and modulate synaptic activity. Under physiological conditions, neuronal-derived nitric oxide (NO) plays an important role in the modulation of a variety of central nervous system (CNS) functions. NO, although short lived, can travel sufficient di...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.06.026
更新日期:2004-09-10 00:00:00