Abstract：
:Intracellular recordings were obtained from CA1 pyramidal neurons in obliquely cut in vitro hippocampal slices. Recurrent IPSPs were elicited by antidromic stimulation of alvear fibers. The mechanisms by which IPSPs depress pyramidal cell excitability were investigated. Recurrent IPSPs could be reversed in sign by small hyperpolarizing currents applied through the recording electrode, indicating an increased membrane conductance. By using an AC bridge circuit it was found that the maximum impedance decrease usually occurred slightly before the peak of the IPSP. Otherwise the time course of the impedance change matched that of the IPSP itself. Inhibitory actions of the conductance increase were studied by adjusting the membrane potential to the IPSP equilibrium potential, thus allowing only the IPSP conductance to play an inhibitory role. Under these conditions non-linear summation of recurrent IPSPs with EPSPs originating in the apical dendrites could be demonstrated only during the initial 15--25 msec ofthe IPSP, which is the period of maximum conductance increase. The inhibition afforded by the hyperpolarization of the recurrent IPSP far outlasts the period of effective EPSP shunting by the inhibitory synaptic currents. The mechanisms of recurrent inhibition in the hippocampus thus appear similar to those operating in spinal motoneuron IPSPs.
journal_name
Brain Resjournal_title
Brain researchauthors
Dingledine R,Langmoen IAdoi
10.1016/0006-8993(80)91068-9subject
Has Abstractpub_date
1980-03-10 00:00:00pages
277-87issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(80)91068-9journal_volume
185pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Propofol (2,6-diisopropylphenol) is an intravenous general anaesthetic which can directly activate and positively modulate the GABAA receptor. The effects of propofol on human recombinant GABAA receptors were studied in Xenopus oocytes expressing either alpha1beta2, alpha1beta2gamma2L, or alpha2beta2gamma2L receptor i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01334-6
更新日期：1998-02-16 00:00:00
abstract：:Using site-specific antibodies, we assessed the effect of aggregation of various length forms of A beta on the immunoreactive profile of the peptides. All of the antibodies tested reacted with monomeric/dimeric forms of A beta 1-42 and its further aggregates. However, antibodies directed against the 1-24 region of A b...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01195-1
更新日期：1995-12-12 00:00:00
abstract：:The GABAB agonist, baclofen, causes a dose-dependent decrease in lordosis, and this effect is attenuated following hypothalamic serotonin, (5-HT) lesions. Baclofen administration is associated with decreased 5-HT activity in the medial preoptic (mPOA) and ventromedial nuclei and enhanced 5-HT activity in the midbrain ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90564-c
更新日期：1991-08-09 00:00:00
abstract：:Previously brain norepinephrine (NE) neurons in the locus coeruleus (LC) have been shown to respond profoundly to external, environmental stimuli and are thought to be involved in behavioral functions such as vigilance, alarm and anxiety reactions to novel and, especially, threatening stimuli. Here we have used electr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90964-9
更新日期：1986-06-04 00:00:00
abstract：:Angiotensin peptides are thought to act as neurotransmitters or neuromodulators in central osmoregulation. We tested the hypothesis that angiotensin peptides are released in the paraventricular nucleus (PVN) of the hypothalamus upon local osmotic stimulation. Brain microdialysis and radioimmunoassay (RIA) techniques w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91215-7
更新日期：1994-02-21 00:00:00
abstract：:To investigate whether a task rule carried over from the preceding trial modifies an early portion of the stimulus-locked lateralized readiness potential (sLRP), participants were asked to perform two different flanker tasks that were switched. One task required a left-hand response for a central letter "H" in a five-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.05.050
更新日期：2010-07-30 00:00:00
abstract：:The discontinuous terminal distributions of thalamo- and nigrostriatal axons were examined in adjacent tissue sections from single cat brains by combined anterograde labeling with tritiated proline autoradiography and wheat germ-horseradish peroxidase histochemistry. Injection of one tracer into the centromedian-paraf...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90287-2
更新日期：1985-05-27 00:00:00
abstract：:The effect of lung inflation on the excitability of inspiratory neurons of the dorsal respiratory group was studied in decerebrate, paralyzed, artificially ventilated cats. Variations in the antidromic latency (AL) were used as a measure of the changes in excitability. The antidromic responses of single cells were rec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91278-3
更新日期：1986-02-26 00:00:00
abstract：:Signal transducer and activator of transcription 3 (STAT3) is a transcription factor abundantly expressed in the postnatal brain that is involved in the differentiation of cultured astrocytes. Thus far, the cellular identity and anatomical distribution of STAT3-expressing cells in the postnatal brain is poorly known. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.04.115
更新日期：2006-07-07 00:00:00
abstract：:Microglial cyclo-oxygenase (COX) expression is considered to be important in the pathogenesis of Alzheimer's disease (AD) and, therefore, constitutes a key target for therapeutic intervention. We investigated the influence of AD plaque associated factors on COX-1 and COX-2 expression and activity in adult human microg...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03164-5
更新日期：2002-10-04 00:00:00
abstract：:The activities of 5'-nucleotidase (EC 3.1.3.5) and of 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNP) (EC 3.1.4.37) were measured in crude membrane preparations from 6 brain regions of hypothyroid rats 31 days and 42 days after conception (8-9 days and 19-20 days after birth respectively) and from normal rats 31, 36...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90185-2
更新日期：1983-04-01 00:00:00
abstract：:Mitochondrial division inhibitor (mdivi-1), a selective inhibitor of a mitochondrial fission protein dynamin-related protein 1 (Drp1), has been shown to exert protective effects in heart and cerebral ischemia-reperfusion models. The present study was designed to investigate the beneficial effects of mdivi-1 against sp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.03.033
更新日期：2015-09-04 00:00:00
abstract：:Following electrophysiological techniques we investigated whether wallerian degeneration of the cat sural nerve may be influenced by (1) its peripheral connection and (2) the distance from the cell body. Distal stumps connected to their innervation sites peripherally showed less degeneration than proximal ones when is...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91332-b
更新日期：1990-08-13 00:00:00
abstract：:Transcription factors of the nuclear factor-kappa B (NF-kappaB) p65/RelA may be involved in neuronal cell death. We examined the involvement of NF-kappaB p65 in N-methyl-D-aspartate (NMDA)-induced upregulation of interleukin (IL)-1beta, a proinflammatory cytokine, and subsequent neurotoxicity in the rat retina. Immuno...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.01.097
更新日期：2007-04-20 00:00:00
abstract：:Environmental risk factors such as stressful experiences have long been recognized to affect seizure susceptibility, but little attention has been paid to the potential effects of improving housing conditions. In this study, we investigated the influence of an enriched environment on epileptogenesis. Epileptic suscept...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03355-3
更新日期：2002-11-08 00:00:00
abstract：:Many of our daily movements use visual information to guide our arms toward objects of interest. Typically, these visually guided movements involve first focusing our gaze on the intended target and then reaching toward the direction of our gaze. The literature on eye-hand coordination provides a great deal of evidenc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.05.057
更新日期：2009-08-11 00:00:00
abstract：:This study examined the effect of feeding either a bland cornstarch-based diet (BCD) or a highly palatable, high fat diet containing sucrose (HPD) on hypothalamic arcuate nucleus (ARC) gene expression for neuropeptide-Y (NPY). Male Sprague-Dawley rats received either BCD ad libitum, HPD ad libitum, HPD pair-fed to the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00755-0
更新日期：1998-09-21 00:00:00
abstract：:The primary olfactory cortex of mouse embryos varying in age from the 13th to the 15th day of gestation is investigated with the aid of several techniques: Nissl and Golgi preparations, autoradiography and electron microscopy. It is observed that the earliest cells to complete their migrations are diffusely scattered ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90641-2
更新日期：1977-03-04 00:00:00
abstract：:We examined the effect of the molarless condition on the dendritic spines of hippocampal pyramidal cells in SAMP8 mice in comparison to its effect on learning ability in a maze test. The molarless condition caused a decrease in the number of the spines of CA1 pyramidal cells only in the aged mice showing a reduced lea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.07.038
更新日期：2005-09-28 00:00:00
abstract：:At various times after spinal nerve injury, dorsal root ganglia (DRGs) from injured segments were removed with attached dorsal roots and spinal nerves. In an in vitro recording chamber, spontaneously active units were recorded from teased dorsal root fascicles. Sustained spontaneous activity could first be recorded at...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02165-4
更新日期：1999-12-04 00:00:00
abstract：:While adult mice receiving picrotoxin (PTX) alone responded with clonic and tonic-clonic seizures, this response was greatly suppressed for mice simultaneously injected with 2,3-butanedione monoxime (BDM). For example, 60% and 10% of the mice convulsed when injected (i.p.) with 3.0 mg/kg PTX alone or PTX plus 205 mg/k...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00175-p
更新日期：1995-04-24 00:00:00
abstract：:NO performs a wide array of cell signaling functions. Neuronal NO synthase (nNOS) immunoreactivity and nicotinamide adenine dinucleotide phosphate diaphorase (NDP) activity, a marker of nNOS, were concentrated at adult rat neuromuscular junctions and persisted in denervated muscle indicating the localization of the en...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00675-0
更新日期：1996-08-19 00:00:00
abstract：:In cats ranging in age from the second week to adult, the postnatal functional development of striate cortical neurons projecting to the superior colliculus (SC) was studied by observing their visual responses, axonal conduction velocities and spontaneous activities. One-hundred-and-fifty-seven cells were identified a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90199-2
更新日期：1983-12-01 00:00:00
abstract：:Calcitonin gene-related peptide (CGRP) and substance P (SP) immunoreactivity was examined in neurons of the monkey trigeminal ganglion. Moreover, CGRP- and SP-positive varicose nerve fibers were found, occasionally forming pericellular arborizations around trigeminal somata, which, at light microscopic level, suggeste...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91337-r
更新日期：1993-12-03 00:00:00
abstract：:Aluminum (Al) concentrations of the rat frontal cortex, parietal cortex, and hippocampus were measured by atomic absorption spectroscopy 16 days after a unilateral intracerebroventricular injection of Na gluconate, Al gluconate, or the cholinotoxin AF64A. A fourth group of rats were injected with AF64A 6 days before i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90946-8
更新日期：1988-03-22 00:00:00
abstract：:To elucidate the intracellular mechanism of seizure discharge, phosphorylation of cellular protein during pentylenetetrazole (PTZ)-induced bursting activity in snail neurons was investigated. PTZ markedly enhanced the phosphorylation of proteins of 34,000 and 50,000 molecular weight. Similar effects were observed by a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91395-8
更新日期：1986-01-01 00:00:00
abstract：:Anorexia nervosa is associated with vasopressin, oxytocin and serotonin abnormalities. Because of the relationship between exercise and anorexia nervosa, we explored the weight-loss syndrome produced by wheel running in food-deprived rats. Its effects on regional vasopressin and oxytocin concentrations were determined...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91659-g
更新日期：1993-05-28 00:00:00
abstract：:By application of the anterograde transport technique of Phaseolus vulgaris leuco-agglutinin the descending autonomic projection of the paraventricular hypothalamic nucleus was investigated. The Phaseolus lectin technique allowed the detection of the cells of origin in the paraventricular PVN, the precise position of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90554-2
更新日期：1985-03-11 00:00:00
abstract：:An analysis of cellular kinetics during closure of the cranial neural folds in the C57BL mouse at 8 and 9 days gestations was obtained by means of tritiated thymidine autoradiography. At 8 days the short generation time (7.5 h) and high labeling index (61.4%) are evidence of intensive proliferative activity occurring ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(81)90049-3
更新日期：1981-10-01 00:00:00
abstract：:The ability of heterotopic noxious stimuli to inhibit the activity of dorsal horn convergent neurones was investigated in both intact anesthetized, and spinal unanesthetized rats. Forty-four convergent neurones in lumbar dorsal horn were recognized by their ability to respond to both noxious and non-noxious natural st...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90412-2
更新日期：1983-09-19 00:00:00
