Synergistic effects of D1 and D2 dopamine agonists on turning behaviour in rats.

abstract：:Arachidonic acid metabolism in primary cultures of astroglial cells prepared from cerebra of rat embryos was examined. Arachidonic acid was mainly metabolized through the lipoxygenase pathway and the major metabolites formed were 12-hydroxyeicosatetraenoic acid (12-HETE), 11-HETE and 15-HETE. By contrast, in C6 cells,...

journal_title：Brain research

authors： Ishizaki Y,Morita I,Murota S

更新日期：1989-08-07 00:00:00

abstract：:Sequential effects--reduced behavioral interference after incongruent trials-provide a unique opportunity to examine the influence of previous experience on current attentional processing. We conducted a theoretical analysis of performance in the Simon paradigm to distinguish an attention account (conflict adaptation)...

journal_title：Brain research

authors： Chen S,Melara RD

更新日期：2009-11-10 00:00:00

abstract：:The effects of microinjection of alpha-noradrenergic agonists and antagonists in the flocculus on the basic gain and adaptibility of vestibulo-ocular and optokinetic responses were investigated. A complementary, previous investigation had shown that the adaptation, but not the basic performance, of compensatory oculom...

journal_title：Brain research

authors： Tan HS,van Neerven J,Collewijn H,Pompeiano O

更新日期：1991-10-25 00:00:00

abstract：:L-3, 4-Dihydroxyphenylalanine (L-dopa) has been widely used for the treatment of Parkinson's disease (PD), but its pharmacokinetics in the striatum have hardly been investigated, especially in primates. In this study, we examined the concentration of L-dopa in plasma and in the extracellular fluid (ECF) of the striatu...

journal_title：Brain research

authors： Zhang J,Qu FR,Nakatsuka A,Nomura T,Nagai M,Nomoto M

更新日期：2003-12-12 00:00:00

abstract：:Reward deficit, expressed as anhedonia, is one of the major symptoms associated with neuropsychiatric disorders, but the underlying maladaptations have not been understood. Herein, we test the hypothesis that the neuropeptide cocaine- and amphetamine-regulated transcript (CART) may participate in the process. The stud...

journal_title：Brain research

authors： Somalwar AR,Choudhary AG,Balasubramanian N,Sakharkar AJ,Subhedar NK,Kokare DM

更新日期：2020-02-01 00:00:00

abstract：:The projections of serotonin-containing neurons of the midbrain raphe nuclei (nucleus raphe dorsalis, nucleus centralis superior) are studied by analysis of axonal transport of labeled amino acids. These results are correlated with regional alterations of serotonin content following midbrain raphe lesions which produc...

journal_title：Brain research

authors： Halaris AE,Jones BE,Moore RY

更新日期：1976-05-14 00:00:00

abstract：:Bilateral microinjection of kainic acid (30-117 pmol) into the substantia nigra induced convulsive seizures resembling those elicited from limbic system structures. The convulsive seizures, which consisted of facial and forelimb clonus with rearing and falling, developed after a latency of more than 30 min and were pr...

journal_title：Brain research

authors： Maggio R,Liminga U,Gale K

更新日期：1990-10-01 00:00:00

abstract：:Spontaneous alternation which is disrupted by lesion of septal dopaminergic (DA) afferents was chosen as a behavioral marker for the study of functional interactions between DA and noradrenergic (NA) innervation of the lateral septum. Three groups of rats were studied: a solvent group which received only vehicle injec...

journal_title：Brain research

authors： Taghzouti K,Le Moal M,Simon H

更新日期：1991-06-21 00:00:00

abstract：:The ketogenic diet (KD) is a non-pharmacological treatment for specific types of epilepsy. In addition, it has been shown to be effective in mitigating other neurologic disorders. The KD is also effective in reducing body mass, leading to an increase in use by the general population for weight loss. As the popularity ...

journal_title：Brain research

authors： Miles KN,Skelton MR

更新日期：2020-05-01 00:00:00

abstract：:Previous studies have shown that steroid receptor coactivator-1 (SRC-1) is involved in the regulation of Purkinje cell development and motor learning, neural stem cell differentiation and reproductive-related plasticity. It is widely distributed in the adult brain, but the aging-related changes in the brain remain unc...

journal_title：Brain research

authors： Zhang D,Guo Q,Bian C,Zhang J,Lin S,Su B

更新日期：2011-03-25 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is the predominant isoform of cyclooxygenase in brain. COX-2 activity produces oxidative stress and results in the production of prostaglandins that have many injurious effects. COX-2 transcription is induced by synaptic activity; therefore, COX-2 activity could contribute to epileptic neurona...

journal_title：Brain research

authors： Kawaguchi K,Hickey RW,Rose ME,Zhu L,Chen J,Graham SH

更新日期：2005-07-19 00:00:00

abstract：:Chemotherapy is an effective treatment but difficult to tolerate due to side effects like vomiting. Studies on the etiology of chemotherapy-related emesis have implicated brainstem nuclei and the neurotransmitter substance P, among other substrates. Since rodents do not vomit, other species have been necessary as alte...

journal_title：Brain research

authors： Ray AP,Darmani NA

更新日期：2007-07-02 00:00:00

abstract：:Neuropeptide-Y (NPY) cells in the intergeniculate leaflet (IGL) are known to modulate effects of arousal on the mammalian circadian system. However, the route through which this information reaches the IGL has not been established. Here, we provide evidence that the orexins (hypocretins) are uniquely positioned as a p...

journal_title：Brain research

authors： Nixon JP,Smale L

更新日期：2005-08-16 00:00:00

abstract：:Electrical and pharmacological properties of currents induced by compounds having affinities for putative sigma receptors were investigated with NCB20 cells by use of the whole-cell patch-clamp technique. Antipsychotics and naloxone induced inward currents with a decrease in membrane conductance at a holding potential...

journal_title：Brain research

authors： Morio Y,Tanimoto H,Yakushiji T,Morimoto Y

更新日期：1994-02-21 00:00:00

abstract：:The effects of the epileptogenic agent, penicillin, on excitatory and inhibitory postsynaptic potentials (EPSPs and IPSPs) were studied in the hippocampal in vitro slice preparation. The actions of penicillin were compared to those of bicuculline, an antagonist of gamma-aminobutyric acid. Neither substance enhanced mo...

journal_title：Brain research

authors： Schwartzkroin PA,Prince DA

更新日期：1980-02-03 00:00:00

abstract：:The aim of this investigation was to determine the incidence of seizure activity in the acute phase following traumatic brain injury. Compression contusion trauma was produced in the right parietal cortex in 19 artificially ventilated rats. Electroencephalographic recordings were carried out in 17 of the animals for 2...

journal_title：Brain research

authors： Nilsson P,Ronne-Engström E,Flink R,Ungerstedt U,Carlson H,Hillered L

更新日期：1994-02-21 00:00:00

abstract：:Iontophoretic injection of cAMP elicits a slow, transient inward current in identified buccal feeding motoneurons and in the giant cerebral interneuron of the snail, Lymnaea stagnalis. The current is voltage independent, and is abolished in the absence of extracellular Na+. Application of the phosphodiesterase inhibit...

journal_title：Brain research

authors： McCrohan CR,Gillette R

更新日期：1988-01-12 00:00:00

abstract：:Dynamin-1 is a multi-domain GTPase that is crucial for the fission stage of synaptic vesicle recycling and vesicle trafficking. In this study, we constructed prokaryotic expression plasmids for the four functional domains of dynamin-1, which are pGEX-4T-2-PH, pGEX-4T-2-PRD, pGEX-4T-2-GED and pGEX-4T-2-GTPase. Glutathi...

journal_title：Brain research

authors： Zhang C,Omran AG,He F,Deng X,Wu L,Peng J,Yin F

更新日期：2014-01-16 00:00:00

abstract：:A diffusion model is described here, which allows for the estimations of drug concentration changes in porous media, such as in slice tissues of the central nervous system (CNS) bathed in unstirred solutions following abrupt changes of drug concentration. This model may be used for the interpretation of data obtained ...

journal_title：Brain research

authors： Lipinski HG,Bingmann D

更新日期：1987-12-22 00:00:00

abstract：:Echo-planar magnetic resonance imaging (EP-MRI), which is novel variant of MRI, is thought to have antidepressant properties in humans and animal models. Using the forced swimming test (FST), we investigated which monoaminergic system in mice is affected by EP-MRI. The short- and long-term effects of EP-MRI on immobil...

journal_title：Brain research

authors： Aksoz E,Aksoz T,Bilge SS,Ilkaya F,Celik S,Diren HB

更新日期：2008-10-21 00:00:00

abstract：:Outbred rat lines such as Wistar rats are commonly used for models of depressive disorders. Such rats arise from random mating schedules. Hence, genetic drift occurs in outbred populations which could lead to genotypic and phenotypic heterogeneity between rats from different vendors. Additionally, vendor specific rear...

journal_title：Brain research

authors： Theilmann W,Kleimann A,Rhein M,Bleich S,Frieling H,Löscher W,Brandt C

更新日期：2016-07-01 00:00:00

abstract：:Recently it was reported that there is an increase in monoamine oxidase B (MAO-B) activity in post-mortem brains of patients with Alzheimer's disease. It was postulated that this increase in MAO-B activity was due to gliosis associated with neuronal degeneration. The aim of the present investigation was to evaluate th...

journal_title：Brain research

authors： Jossan SS,Hiraga Y,Oreland L

更新日期：1989-01-09 00:00:00

abstract：:Myelin of several Caudata (Urodela) species appears to be unique in the fact that it lacks hydroxycerebrosides and hydroxysulfatides although it contains their non-hydroxy counterparts. Comparison of the nerve conduction velocities in the Urodeles Necturus (salamander) and Notophthalmus (newt) with that in a reptile, ...

journal_title：Brain research

authors： Ki PF,Kishimoto Y,Lattman EE,Stanley EF,Griffin JW

更新日期：1985-10-14 00:00:00

abstract：:Treatment of castrated quail with testosterone (T) reliably activates male copulatory behavior and, at the same time, increases the aromatase activity (AA), the number of aromatase-immunoreactive (ARO-ir) cells and the concentration of aromatase mRNA as measured by RT-PCR in the brain. All these effects can be mimicke...

journal_title：Brain research

authors： Foidart A,Tlemçani O,Harada N,Abe-Dohmae S,Balthazart J

更新日期：1995-12-01 00:00:00

abstract：:The healthy maturation of the brain is one of the intriguing topics that need to be investigated to understand human brain and child development. The present study aimed to investigate the development of memory processes both for auditory and visual memory using electroencephalography (EEG)-Brain Dynamics methodologie...

journal_title：Brain research

authors： Güntekin B,Uzunlar H,Çalışoğlu P,Eroğlu-Ada F,Yıldırım E,Aktürk T,Atay E,Ceran Ö

更新日期：2020-11-15 00:00:00

abstract：:The adaptation to hypoxia and hypercapnia requires the activation of several anatomical structures along the neuraxis. In this study, using Fos immunoreactivity, we sought to map neuronal populations involved in chemoreflex networks activated during the responses to moderate hypoxia (O(2) 11%), and hypercapnia (CO(2) ...

journal_title：Brain research

authors： Berquin P,Bodineau L,Gros F,Larnicol N

更新日期：2000-02-28 00:00:00

abstract：:IgLONs are a family of four GPI-anchored cell adhesion molecules that regulate neurite outgrowth, synaptogenesis and may act as tumour suppressor genes. IgLONs are thought to function as monomers or homodimers and we have proposed that IgLONs also act as heterodimeric complexes termed Dimeric IgLONs or DIgLONs. Here w...

journal_title：Brain research

authors： Akeel M,McNamee CJ,Youssef S,Moss D

更新日期：2011-02-16 00:00:00

abstract：:Transplantation of mesenchymal stem cells (MSCs) prepared from adult bone marrow (BMSCs) has been reported to ameliorate functional deficits in several CNS diseases in experimental animal models. Bone marrow was enriched in MSCs by selecting for plastic-adherent cells that were grown to confluency in appropriate cultu...

journal_title：Brain research

authors： Kim S,Honmou O,Kato K,Nonaka T,Houkin K,Hamada H,Kocsis JD

更新日期：2006-12-06 00:00:00

abstract：:Coated vesicles within dentate gyrus granule cell dendrites were found free in the cytoplasm and also attached to the smooth endoplasmic reticulum and plasmalemma. Coated vesicles began increasing in number 40-48 h following partial dendritic deafferentation. This increase continued up to 15-30 days postlesion, after ...

journal_title：Brain research

authors： McWilliams JR,Lynch G

更新日期：1981-04-27 00:00:00

abstract：:Tetanic stimulation at 50 Hz elicited long-term potentiation (LTP) in the hippocampal CA1 region of 28-day-old control animals. In contrast, no significant potentiation was seen following the same tetanus in animals chronically exposed to 1000 ppm of lead acetate during development. Gender differences were observed in...

journal_title：Brain research

authors： Zaiser AE,Miletic V

更新日期：2000-09-08 00:00:00