Abstract：
:L-3, 4-Dihydroxyphenylalanine (L-dopa) has been widely used for the treatment of Parkinson's disease (PD), but its pharmacokinetics in the striatum have hardly been investigated, especially in primates. In this study, we examined the concentration of L-dopa in plasma and in the extracellular fluid (ECF) of the striatum in common marmosets using microdialysis and high-performance liquid chromatography (HPLC) with electrochemical detection. With a clinically therapeutic dosage of L-dopa/benserazide (20/5 mg/kg, p.o.), the t(max) of L-dopa was 30 min in plasma and 60-90 min in ECF of striatum. Mean C(max) was 20.3 microM in plasma and 442.9 nM in ECF of striatum, which is about 2.2% of that in plasma. The L-dopa concentration in ECF is much lower than those previously applied during in vivo studies for L-dopa toxicity.
journal_name
Brain Resjournal_title
Brain researchauthors
Zhang J,Qu FR,Nakatsuka A,Nomura T,Nagai M,Nomoto Mdoi
10.1016/j.brainres.2003.08.065subject
Has Abstractpub_date
2003-12-12 00:00:00pages
54-8issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899303036734journal_volume
993pub_type
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