The shark GABA-benzodiazepine receptor: further evidence for a not so late phylogenetic appearance of the benzodiazepine receptor.

abstract：:Histaminergic neurons of the tuberomammillary nucleus (TMN) are hypothesized to promote wakefulness, but little is known about the activity of these cells during spontaneous behavior. We measured histaminergic neuron activity in the dorsomedial, ventrolateral, and caudal TMN at four different times using Fos and adeno...

journal_title：Brain research

authors： Ko EM,Estabrooke IV,McCarthy M,Scammell TE

更新日期：2003-12-05 00:00:00

abstract：:The effects of microinjection of alpha-noradrenergic agonists and antagonists in the flocculus on the basic gain and adaptibility of vestibulo-ocular and optokinetic responses were investigated. A complementary, previous investigation had shown that the adaptation, but not the basic performance, of compensatory oculom...

journal_title：Brain research

authors： Tan HS,van Neerven J,Collewijn H,Pompeiano O

更新日期：1991-10-25 00:00:00

abstract：:Many phosphorylated extracellular signal-regulated kinase (pERK)-immunoreactive (IR) cells are expressed in the trigeminal spinal subnucleus caudalis (Vc), upper cervical spinal cord (C1-C2), nucleus tractus solitarii (NTS) and paratrigeminal nucleus (Pa5) after capsaicin injection into the whisker pad (WP), masseter ...

journal_title：Brain research

authors： Tsujimura T,Shinoda M,Honda K,Hitomi S,Kiyomoto M,Matsuura S,Katagiri A,Tsuji K,Inoue M,Shiga Y,Iwata K

更新日期：2011-10-12 00:00:00

abstract：:The production and localization of cell-associated forms of beta-amyloid precursor protein (APP) of Alzheimer's disease was investigated in primary cultures of mouse glial cells. In both oligodendrocytes and astrocytes, immunofluorescence staining with an antibody against the carboxy terminus of APP revealed an intens...

journal_title：Brain research

authors： Mizuguchi M,Ikeda K,Kim SU

更新日期：1992-07-03 00:00:00

abstract：:We previously reported that the antinociceptive effect of morphine on the thermal tail withdrawal reflex (tail flick, TF) was reduced in rats that had practiced the TF response prior to morphine administration. This phenomenon, termed behavioral tolerance, was observed even when rats were spinally transected following...

journal_title：Brain research

authors： Advokat C,McInnis C

更新日期：1992-05-22 00:00:00

abstract：:In the present studies we have examined the effects of a new calcium channel blocker, LY393615 ((N-Butyl-[5,5-bis-(4-fluorophenyl)tetrahydrofuran-2-yl]methylamine hydrochloride, NCC1048) in a model of hypoxia-hypoglycaemia in vitro and in a gerbil model of global and in two rat models of focal cerebral ischaemia in vi...

journal_title：Brain research

authors： O'Neill MJ,Hicks CA,Ward MA,Osborne DJ,Wishart G,Mathews KS,McLaughlin DP,Stamford JA,McCarty DR,Patrick KE,Roman C,Fleisch JH,Gilmore J,Boot JR

更新日期：2001-01-05 00:00:00

abstract：:The effect of isradipine, a dihydropyridine calcium antagonist, on morphine-induced place preference and analgesia in rats and mice was studied. Isradipine (0.6-5.0 mg/kg s.c.) inhibited an acquisition of morphine-induced place preference in rats and mice in a dose-related manner. Isradipine did not affect or strength...

journal_title：Brain research

authors： Kuzmin A,Patkina N,Pchelintsev M,Zvartau E

更新日期：1992-10-16 00:00:00

abstract：:We tested the hypothesis that a single systemic injection of 380 mg/kg of the muscarinic agonist pilocarpine would produce more diffuse and severe seizure-induced brain damage than a single injection of lithium (3 mEq/kg) followed 4 h later by < 1/10 the dosage of pilocarpine. The hypothesis was not supported; the pat...

journal_title：Brain research

authors： Bureau YR,Peredery O,Persinger MA

更新日期：1994-06-20 00:00:00

abstract：:The type and cell size of parvalbumin-immunoreactive (PV-Ir) neurones were examined in 14 postmortem brains from elderly control and Alzheimer-type dementia (ATD) patients with the aid of an image analyser. Morphological features of PV-Ir neurones suggested the existence of PV in the non-pyramidal interneurones in the...

journal_title：Brain research

authors： Arai H,Emson PC,Mountjoy CQ,Carassco LH,Heizmann CW

更新日期：1987-08-18 00:00:00

abstract：:We studied the effect of the cortical projection from the basal forebrain on the cerebral cortical metabolism using positron emission tomography (PET) with [(18)F] fluorodeoxyglucose. Unilateral damage of the nucleus basalis magnocellularis (NBM) did not cause a permanent reduction of cortical metabolism: recovery was...

journal_title：Brain research

authors： Katsumi Y,Hanakawa T,Fukuyama H,Hayashi T,Nagahama Y,Yamauchi H,Ouchi Y,Tsukada H,Shibasaki H

更新日期：1999-08-07 00:00:00

abstract：:Levodopa (L-DOPA) is widely used for symptomatic management in Parkinson's disease. We recently showed that (-)-epigallocatechin-3-gallate, a tea polyphenol, not only inhibits L-DOPA methylation, but also protects against oxidative hippocampal neurodegeneration. In the present study, we sought to determine several oth...

journal_title：Brain research

authors： Kang KS,Yamabe N,Wen Y,Fukui M,Zhu BT

更新日期：2013-02-25 00:00:00

abstract：:Experiments were carried out on UC-11MG human astrocytoma cells, a continuous cell line that expresses a broad range of the biochemical and electrophysiological properties found in well-differentiated astrocytes. Because of a number of recent reports that astrocytes may express receptors for a variety of neuro-active ...

journal_title：Brain research

authors： Lucherini MJ,Gruenstein E

更新日期：1992-10-02 00:00:00

abstract：:A pair of neurons exhibiting postinhibitory rebound, if connected through reciprocally inhibitory chemical synapses, will exhibit a stable pattern of alternating bursts. If two such oscillating pairs, of similar but not identical properties are connected by means of an electrical synapse and an inhibitory chemical syn...

journal_title：Brain research

authors： Mulloney B,Perkel DH,Budelli RW

更新日期：1981-12-14 00:00:00

abstract：:To identify parameters of optic tract growth that may be independent of the region of the CNS in which the tract develops, eye primordia of embryonic Rana pipiens were transplanted to a variety of ectopic locations adjacent to the hindbrain and spinal cord. Longitudinal growth direction, cross-sectional growth positio...

journal_title：Brain research

authors： Constantine-Paton M

更新日期：1978-12-08 00:00:00

abstract：:On the first day after hatching 106 domestic chicks were injected with (14-C)uracil and exposed to a yellow or a red rotating flashing light for 72 min. Shortly before they were killed and 115 min after injection they were given a choice between the two lights. Incorporation of the (14-C)uracil into 4 regions of the b...

journal_title：Brain research

authors： Bateson PP,Horn G,Rose SP

更新日期：1975-02-07 00:00:00

abstract：:In rat hippocampal slices, the novel metabotropic glutamate receptor (mGluR) ligand, (1S,1'R,2'R,3'R)-2-(2,3-dicarboxycyclopropyl)glycine (DCG-IV) enhanced the stimulation of polyphosphoinositide (PPI) hydrolysis elicited by quisqualate or by submaximal concentrations of ibotenate or (1S,3R)-1-aminocyclopentane-1,3-di...

journal_title：Brain research

authors： Genazzani AA,L'Episcopo MR,Casabona G,Shinozaki H,Nicoletti F

更新日期：1994-10-03 00:00:00

abstract：:The aim of this work was to characterize the interaction of the Na+-channel toxin, purified from venom of the scorpion Leiurus quinquestriatus, with microtubule proteins in vitro. The toxin enhanced microtubule assembly, causing the formation of microtubule 'bundles'. It interacted with the Na+-channel 270 kDa subunit...

journal_title：Brain research

authors： Hargreaves AJ,Montejo de Garcini E,Avila J

更新日期：1986-07-01 00:00:00

abstract：:Hippocampal neurogenesis plays a very important role in learning and memory functions. In a search for best neurological drugs that protect neuronal cells and stimulate neurogenesis with no side effects, cannabinoids proved to be a strong group of substances having many beneficial properties. The aim of this study was...

journal_title：Brain research

authors： Andres-Mach M,Haratym-Maj A,Zagaja M,Rola R,Maj M,Chrościńska-Krawczyk M,Luszczki JJ

更新日期：2015-10-22 00:00:00

abstract：:Microspectrofluorimetric measurements of excitatory amino acid-evoked rises in intracellular free calcium concentration ([Ca2+]i), electrophysiological measurements of currents through single NMDA receptor-operated ion channels and estimates of cellular viability following NMDA challenge were employed to examine the i...

journal_title：Brain research

authors： Sawyer DC,McLarnon JG,Church J

更新日期：1995-11-06 00:00:00

abstract：:The distribution of retinotectal afferents has been studied by autoradiography in 4 adult cats. The findings suggest that crossed and uncrossed retinal fibers terminate in a striking cluster-and-sheet pattern that varies systematically with respect to the retinotopic map of the colliculus. Following unilateral eye inj...

journal_title：Brain research

authors： Graybiel AM

更新日期：1975-10-10 00:00:00

abstract：:The activities of tyrosine hydroxylase and dopamine-beta-hydroxylase were measured in the medial basal hypothalamus and remaining hyothalamic tissue of female rats at various times during diestrus 2, proestrus and estrus. Tyrosine hydroxylase activity in the medial basal hypothalamus was significantly lower at 12.00 h...

journal_title：Brain research

authors： Carr LA,Voogt JL

更新日期：1980-09-08 00:00:00

abstract：:Adenosine and its agonists exert a depressant effect on neuronal activity by interacting with the adenosine A1 receptor. There is now also evidence for electrophysiological effects mediated by adenosine receptors other than the A1 type, possibly A2 receptors. A1 and A2 receptor-induced changes in the electrical proper...

journal_title：Brain research

authors： Ameri A,Jurna I

更新日期：1991-04-12 00:00:00

abstract：:Cerebrovascular diseases are currently a major global health problem. Considering the limitations of current therapy, the search for new alternatives for the treatment of these diseases is necessary and, in this context, curcumin, a molecule that has neuroprotective properties already described in the literature. A li...

journal_title：Brain research

authors： Marques MS,Cordeiro MF,Marinho MAG,Vian CO,Vaz GR,Alves BS,Jardim RD,Hort MA,Dora CL,Horn AP

更新日期：2020-11-01 00:00:00

abstract：:Choline uptake and ecto-cholinesterase activities have been measured in intact astroblast and neuroblast cultures. The data show that choline uptake is dependent upon the ionic composition of the culture medium and is sensitive to metabolic inhibitors. However, the high concentrations of the inhibitors necessary for t...

journal_title：Brain research

authors： Massarelli R,Stefanovic V,Mandel P

更新日期：1976-08-06 00:00:00

abstract：:This study investigated the long-lasting effects of chronic ethanol consumption on the distribution of Schaffer collateral-commissural (SCH/COM) afferents within stratum radiatum of rat hippocampal CA1. Experimental animals were fed an ethanol-containing liquid diet for 20 weeks but were withdrawn from the special die...

journal_title：Brain research

authors： Abraham WC,Manis PB,Hunter BE,Zornetzer SF,Walker DW

更新日期：1982-04-08 00:00:00

abstract：:It has been demonstrated that castration alters the functioning of the olfactory bulb (OB)-norepinephrine (NE) system. In the present experiment, we examined one of the mechanisms by which castration modulates the OB-NE system by comparing NE uptake activity between intact and castrated male rats as studied using an i...

journal_title：Brain research

authors： Shang Y,Dluzen DE

更新日期：1998-01-01 00:00:00

abstract：:The status of blood-brain barrier (BBB) permeability was investigated in the twitcher, an authentic murine model of globoid cell leukodystrophy (GLD, Krabbe disease) and cuprizone-intoxicated mice. Although extensive demyelination was noted in the CNS of both mice and additionally, macrophage infiltration was pronounc...

journal_title：Brain research

authors： Kondo A,Nakano T,Suzuki K

更新日期：1987-11-03 00:00:00

abstract：:Excitotoxic effects leading to neuronal cell degeneration are often accompanied by a prolonged increase in the intracellular level of Ca(2+) ions and L-glutamate-induced toxicity is assumed to be mediated via a Ca(2+)-dependent mechanism. Due to their buffering properties, EF-hand Ca(2+)-binding proteins (CaBPs) can a...

journal_title：Brain research

authors： D'Orlando C,Celio MR,Schwaller B

更新日期：2002-08-02 00:00:00

abstract：:By ligating specific nerves in the cat, the central processes of the nodose ganglion (NG) cells containing substance P-like immunoreactive materials were shown, immunohistochemically, to run through the cross-anastomosis made between the cranial end of the NG and the caudal end of the superior cervical ganglion (SCG),...

journal_title：Brain research

authors： Hayashi H,Ohsumi K,Fujiwara M,Mizuno N

更新日期：1983-06-27 00:00:00

abstract：:Extracellular action potentials were recorded from 691 neurons in the ventromedial hypothalamus (VMH) of urethane anesthetized female rats under acute and chronic sham-operated and hyperprolactinemic conditions. Hyperprolactinemia was produced by transplanting pituitaries under the kidney capsules. Neuronal excitabili...

journal_title：Brain research

authors： Moss RL,Chan A,Dudley CA

更新日期：1985-11-04 00:00:00