Abstract:
:Many phosphorylated extracellular signal-regulated kinase (pERK)-immunoreactive (IR) cells are expressed in the trigeminal spinal subnucleus caudalis (Vc), upper cervical spinal cord (C1-C2), nucleus tractus solitarii (NTS) and paratrigeminal nucleus (Pa5) after capsaicin injection into the whisker pad (WP), masseter muscle (MM), digastric muscle (DM) or sternohyoideus muscle (SM). The pERK-IR cells also showed NeuN immunoreactivity, indicating that ERK phosphorylation occurs in neurons. The pERK-IR cells were significantly reduced after intrathecal injection of MEK 1/2 inhibitor PD98059. The pERK-IR cells expressed bilaterally in the Vc and C1-C2 after capsaicin injection into the unilateral DM or SM, whereas unilaterally in the Vc and C1-C2 after unilateral WP or MM injection. After capsaicin injection into the WP or MM, the pERK-IR cell expression in the Vc was restricted rostrocaudally within a narrow area. However, the distribution of pERK-IR cells was more wide spread without a clear peak in the Vc and C1-C2 after capsaicin injection into the DM or SM. In the NTS, the unimodal pERK-IR cell expression peaked at 0-720μm rostral from the obex following capsaicin injection into WP, MM, DM or SM. In the ipsilateral Pa5, many pERK-IR cells were observed following capsaicin injection into the SM. The number of swallows elicited by distilled water administration was significantly smaller after capsaicin injection into the WP, MM or DM but not SM compared to that of vehicle-injected rats. Various noxious inputs due to the masticatory or swallowing-related muscle inflammation may be differentially involved in muscle pain and swallowing reflex activity.
journal_name
Brain Resjournal_title
Brain researchauthors
Tsujimura T,Shinoda M,Honda K,Hitomi S,Kiyomoto M,Matsuura S,Katagiri A,Tsuji K,Inoue M,Shiga Y,Iwata Kdoi
10.1016/j.brainres.2011.08.032subject
Has Abstractpub_date
2011-10-12 00:00:00pages
45-54eissn
0006-8993issn
1872-6240pii
S0006-8993(11)01537-Xjournal_volume
1417pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Acute administration of diazepam (2 mg/kg i.p.) to rats decreased the number of head-dips, locomotor activity and the number of rears made in the holeboard apparatus, indicating sedative effects. After daily treatment for 7 days with diazepam (2 mg/kg) tolerance developed to all these behavioural effects, despite seru...
journal_title:Brain research
pub_type: 杂志文章
doi:
更新日期:1996-09-23 00:00:00
abstract::Glutamate is an excitatory neurotransmitter implicated in the pathogenesis of psychiatric disorders. Glutamate results in the activation of an enzyme called glycogen synthase kinase-3 (GSK-3) acting through N-methyl-d-aspartate (NMDA) receptors. Impaired expression of GSK-3 affects behavior and neurochemicals level in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.10.002
更新日期:2019-02-01 00:00:00
abstract::Light microscopic double labeling immunocytochemistry for vasoactive intestinal peptide (VIP) and gonadotrophin-releasing hormone (GnRH) was carried out on the hypothalami of male and female rats. It was found that the number of VIP boutons that terminate on GnRH neurons and the percentage of GnRH neurons contacted by...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00208-x
更新日期:1998-06-08 00:00:00
abstract::Extracellular action potentials were recorded from 691 neurons in the ventromedial hypothalamus (VMH) of urethane anesthetized female rats under acute and chronic sham-operated and hyperprolactinemic conditions. Hyperprolactinemia was produced by transplanting pituitaries under the kidney capsules. Neuronal excitabili...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90864-9
更新日期:1985-11-04 00:00:00
abstract::Tactile stimulation of the body surface elicited climbing fiber responses in 5% of the 839 Purkinje cells recorded in the caudal posterior vermis (lobules VII-IX) of cats anesthetized with sodium pentobarbital. The cells responsive to tactile stimulation were mainly encountered around the prepyramidal fissure between ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90084-o
更新日期:1990-06-11 00:00:00
abstract::The effect of cerebellar stimulation on the accommodation of the lens was examined in anesthetized cats. An infrared optometer was used to measure the refractive power of the lens during stimulation of the cerebellum. The area giving responses within latencies shorter than 160 msec and amplitudes larger than 0.15 diop...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90334-7
更新日期:1978-09-29 00:00:00
abstract::Migraine headache is proposed to be mediated by nitric oxide (NO). Suitable mechanisms for eliciting increases in brain NO concentration in migraineurs have not yet been identified, although, animal models highlight cortical spreading depression (CSD) as a potential candidate. These studies have focused on CSD-associa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)03191-7
更新日期:2001-02-09 00:00:00
abstract::The N-methyl-D-aspartate (NMDA) subtype of excitatory amino acid receptor is linked to an ion channel that is blocked by the phencyclidine analog N-(1-[thienyl]cyclohexyl)piperidine (TCP). Previous studies have shown that NMDA and glycine act together to increase the access of [3H]TCP to its binding site, presumably b...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90918-2
更新日期:1990-05-21 00:00:00
abstract::We have investigated the influence of central noradrenergic and dopaminergic systems on the susceptibility of rats to seizures in the kainic acid (KA)-model of epilepsy. In the dose range of 0.75 to 10 mg/kg s.c., KA dose-dependently induced characteristic behavioural changes. Partial depletion of noradrenaline (NA) a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90219-9
更新日期:1989-08-28 00:00:00
abstract::Ultrastructural localization of a calcium-binding protein, calretinin, in the cerebellar cortex of the rat was examined with an immunoperoxidase method. The cerebellar lobule V was investigated in detail. In the molecular layer, calretinin immunoreactivity was found in parallel fibers and in their varicosities that fo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90915-a
更新日期:1993-06-11 00:00:00
abstract::The purpose of the present study is to characterize the striatum of the lamprey by immunohistochemical and tracing techniques. Cells immunoreactive for GABA and substance P (SP), and positive for acetylcholinesterase, are present in the lamprey striatum. Immunoreactive (ir) fibers were detected by antisera raised agai...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00701-4
更新日期:1997-08-22 00:00:00
abstract::The purpose of this study was to compare the relative effects of mannitol and hypertonic saline (HTS) on calpain activity, apoptosis and neuroinflammatory response induced by experimental cortical contusion. Four groups of 5 Sprague-Dawley male rats were submitted to focal brain injury produced by exposing the parieta...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.05.045
更新日期:2006-07-26 00:00:00
abstract::The possible involvement of protein kinase A (PKA) in the muscarinic inhibition of the slow afterhyperpolarizing current (IAHP) was investigated in rat hippocampal pyramidal cells. IAHP was recorded using the whole cell method in hippocampal slices, and Rp-cAMPS, a PKA antagonist, was applied intracellularly. The inhi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90096-5
更新日期:1994-05-23 00:00:00
abstract::Cholinergic mechanisms in the septohippocampal pathway contribute to several cognitive functions and impaired cholinergic transmission in this pathway may be related to the memory loss and dementia that accompanies normal aging and Alzheimer's disease and behavioral studies suggest that muscarinic mechanisms in the me...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00729-x
更新日期:1998-09-14 00:00:00
abstract::Atropine (5 nM to 5 muM), but not D-tubocurarine or hexamethonium, enhanced the release of acetylcholine (ACh) from rat brain cortical slices exposed to high K+. The enhancement was dose-dependent, and it could be partially antagonized by oxotremorine (50-500 muM) or by dibutyryl or 8-bromo-cyclic GMP (1 mM), but not ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90836-7
更新日期:1980-01-20 00:00:00
abstract::Effects of inhibition of nitric oxide (NO) synthesis on the cerebrovascular autoregulatory vasodilator response to hypotension were studied in conscious rats. Cerebral blood flow (CBF) was determined with [14C]iodoantipyrine in a saline-treated control group and in three groups following inhibition of NO synthase acti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00129-e
更新日期:1995-04-24 00:00:00
abstract::The accessibility of macromolecules to the postnatal mammalian central nervous system is a subject of controversy and importance. One of the biologically important macromolecules in neural development, nerve growth factor (NGF), is thought to be unable to cross the blood-brain barrier in postnatal mammals. In this stu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91775-n
更新日期:1993-05-14 00:00:00
abstract::Phospholipid extracts from 48 intracranial tumors were analyzed using 31P NMR. Phospholipids commonly identified in the tumor spectra included phosphatidylglycerol (PG), phosphatidic acid (PA), diphosphatidylglycerol (DPG), uncharacterized phospholipid (U), ethanolamine plasmalogen (EPLAS), phosphatidylethanolamine (P...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91041-3
更新日期:1994-06-27 00:00:00
abstract::Murine brain cells differentiated for 19 days in culture before treatment for 5 days with 10 microM diazepam. Radioligand binding to the benzodiazepine receptors on membranes obtained from these cultures was determined by the filtration assay method. Decreased binding was observed in the membranes from treated culture...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90117-8
更新日期:1983-12-12 00:00:00
abstract::Sites which bind oxytocin and vasopressin with high affinity were detected in the brain and upper spinal cord of 12 human subjects, using in vitro light microscopic autoradiography. Tissue sections were incubated with tritiated vasopressin, tritiated oxytocin or an iodinated oxytocin antagonist. The ligand specificity...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90345-v
更新日期:1991-08-02 00:00:00
abstract::The objective of this study was to determine whether the aging process influences the changes in the electrophysiological properties of motoneurons that occur as a consequence of axotomy. Accordingly, using intracellular recording and stimulating techniques, the basic electrical properties of control (unaxotomized) an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90594-y
更新日期:1992-01-20 00:00:00
abstract::The effects of 4 anaesthetics, halothane, alpha-chloralose, chloral hydrate and pentobarbitone, on rat striatal extracellular dihydroxyphenylacetic acid (DOPAC) levels were determined using in vivo voltammetry. Stable baseline levels of DOPAC were maintained under halothane/N2O and alpha-chloralose while the extracell...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90270-2
更新日期:1986-07-30 00:00:00
abstract::The block of the transient outward K-current, I(K(A)) by 4-aminopyridine (4-AP) and blood-depressing substances (BDS) was investigated in identified Helix pomatia neurons (LPa3) using the two microelectrode voltage-clamp technique. The present study shows that 4-AP inhibits I(K(A)) in snail neurons in a voltage- and c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03351-0
更新日期:2002-02-15 00:00:00
abstract::Tumor necrosis factor-alpha (TNFalpha) affects several CNS functions such as regulation of sleep, body temperature, and feeding during pathology. There is also evidence for TNFalpha involvement in physiological sleep regulation, e.g., TNFalpha induces sleep and brain levels of TNFalpha increase during prolonged wakefu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.06.044
更新日期:2005-08-16 00:00:00
abstract::Effects of systemic administration of a single dose (50 mg/kg) of ethosuximide (ESM) on extracellularly recorded thalamic (nucleus centralis lateralis, CL; nucleus reticularis, RE) and cortical neurons and on cortical EEG activity of acute cats, have been studied. In intact animals ESM led to: (a) desynchronization of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90280-1
更新日期:1989-09-18 00:00:00
abstract::Weaver mutant mice alternated above chance levels but less often than normal mice in a 2-trial spontaneous alternation test. When the inter-trial (or retention) interval was manipulated, the weaver mutants alternated above chance levels only at the shortest (15 s) but not at the longest (4 or 5 min) intervals, contrar...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91265-5
更新日期:1986-11-19 00:00:00
abstract::Previous studies showed that electroacupuncture (EA) significantly attenuates inflammatory hyperalgesia in a complete Freund's adjuvant (CFA)-induced inflammatory pain rat model. The present study demonstrates that pretreatment with Derm-sap, a selective toxin for neurons that contain mu opioid receptor (MOR), specifi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.05.008
更新日期:2005-06-28 00:00:00
abstract::Rats were given sham, cortical, or hippocampal lesions and sacrificed 7 or 28 days following surgery. Levels of norepinephrine, dopamine, and the major dopamine metabolites, 3,4-dihydroxyphenylacetic acid and homovanillic acid (HVA), were assayed in 3 brain regions. At day 7 there was a decrease in dopamine utilizatio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90996-9
更新日期:1982-12-02 00:00:00
abstract::The peak-to-peak amplitude of temporal middle latency response (MLR) of the guinea pig, evoked by a click in the contralateral ear, according to the recording side, is increased with the presence of continuous white noise (CWN) in the ipsilateral ear and this specialty is defined as the white noise enhancement (WNE). ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.05.015
更新日期:2004-08-13 00:00:00
abstract::GABA levels, high affinity GABA uptake and glutamic acid decarboxylase levels are reduced in rat ventroanterolateral thalamic nucleus after destruction of the entopeduncular nucleus with kainic acid. This is strong evidence that GABA is an entopedunculothalamic neurotransmitter. The striatoentopeduncular pathway is al...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90693-4
更新日期:1981-02-23 00:00:00