Plasma nerve growth factor access to the postnatal central nervous system.

abstract：:38 primary afferents originating from de-efferented cat tibialis anterior muscle spindles were investigated. Ramp-and-hold stretches of the host muscle were performed with a varying amount of muscle pre-stretch while recording the primary afferent discharges. From the discharge responses an interspike interval functio...

journal_title：Brain research

authors： Awiszus F,Schäfer SS

更新日期：1993-05-28 00:00:00

abstract：OBJECTIVE:This study aimed to investigate whether β-amyloid (Aβ) was able to enhance neurocan expression in a Sox9 dependent manner in astrocytes. METHODS AND MATERIALS:Astrocytes were incubated with Aβ at different concentrations, the expression of Sox9 and neurocan was detected by Western blot assay. Meanwhile, the ...

journal_title：Brain research

authors： Yan H,Zhu X,Xie J,Zhao Y,Liu X

更新日期：2016-09-01 00:00:00

abstract：:These studies investigated autoregulation of glucocorticoid receptor (GR) protein expression and activation in rat brain using western blot methodology. By comparing GR immunoblot reactivity present in various tissue subcellular preparations we were able to discriminate between corticosterone-induced changes in GR act...

journal_title：Brain research

authors： Spencer RL,Kalman BA,Cotter CS,Deak T

更新日期：2000-06-23 00:00:00

abstract：:The role of calcium and protein kinases in rhythmic activity induced by muscarinic receptor activation in the CA1 area in rat hippocampal slices was investigated. Extracellular recording showed that carbachol (20 microM) induced synchronized field potential activity with a dominant frequency of 7.39+/-0.68 Hz. Pretrea...

journal_title：Brain research

authors： Alberi S,Boeijinga PH,Raggenbass M,Boddeke HW

更新日期：2000-07-28 00:00:00

abstract：:We studied the short- and long-term epileptogenic effects of massed stimulation (MS) of the piriform cortex. Sprague-Dawley rats with electrodes implanted bilaterally in the anterior piriform cortex and the dorsal and ventral hippocampi underwent MS: electrical stimulation of the left piriform cortex every 5 min for 6...

journal_title：Brain research

authors： Timofeeva OA,Peterson GM

更新日期：1997-04-18 00:00:00

abstract：:It has been suggested that individual predisposition to develop amphetamine self-administration is associated with impairment in corticosteroid negative feedback mechanisms. Since corticosteroid receptors, particularly those in the hippocampus, are involved in corticosterone feedback sensitivity, we examined the relat...

journal_title：Brain research

authors： Maccari S,Piazza PV,Deminière JM,Angelucci L,Simon H,Le Moal M

更新日期：1991-05-10 00:00:00

abstract：:Eleven beta-carbolinium compounds (beta C+s) and MPP+ were stereotaxically injected (40-200 nmol in 5 microliter of vehicle) unilaterally into the substantia nigra of anesthetized adult male Sprague-Dawley rats. The rats were sacrificed after three weeks. The ipsilateral striatum was analyzed for dopamine and DOPAC le...

journal_title：Brain research

authors： Neafsey EJ,Albores R,Gearhart D,Kindel G,Raikoff K,Tamayo F,Collins MA

更新日期：1995-03-27 00:00:00

abstract：:The relative potencies of the stereoisomers of ketamine, N-allylnormetazocine and cyclazocine were determined at mu opiate and sigma opiate/phencyclidine (PCP) receptors in vitro in rat brain homogenates, as well as in a discriminative stimulus behavioral paradigm in rats trained to discriminate PCP from saline. In al...

journal_title：Brain research

authors： Zukin SR,Brady KT,Slifer BL,Balster RL

更新日期：1984-02-27 00:00:00

abstract：:We have sought to determine if changes in arterial and gastric pressure occurred with selective chemical stimulation of the dorsomedial NTS. Substance P (SP) and L-glutamate (L-glu), but not acetylcholine (ACh), elicited a dose-dependent decrease in tonic gastric pressure and inhibited gastric phasic activity. As prev...

journal_title：Brain research

authors： Spencer SE,Talman WT

更新日期：1986-10-22 00:00:00

abstract：:Visual spatial orienting of attention towards exogenous cues has been one of the attentional functions considered to be spared in ADHD. Here we present a design in which 60 (30 ADHD) children, age: 10.9±1.4, were asked to covertly orient their attention to one or two (out of four) cued locations, and search for a targ...

journal_title：Brain research

authors： Ortega R,López V,Carrasco X,Anllo-Vento L,Aboitiz F

更新日期：2013-02-01 00:00:00

abstract：:Measurements of extracellular Ca2+ and K+ activities [( Ca2+]o, [K+]o) in the superfused cat carotid body in vitro with triple-barrelled ion-selective electrodes have shown that hypoxia induced a decrease in [Ca2+]o of 0.035 +/- 0.17 mM (mean +/- S.D.; n = 17) and a biphasic change in [K+]o which consisted of an incre...

journal_title：Brain research

authors： Delpiano MA,Acker H

更新日期：1989-03-20 00:00:00

abstract：:Previously brain norepinephrine (NE) neurons in the locus coeruleus (LC) have been shown to respond profoundly to external, environmental stimuli and are thought to be involved in behavioral functions such as vigilance, alarm and anxiety reactions to novel and, especially, threatening stimuli. Here we have used electr...

journal_title：Brain research

authors： Elam M,Thorén P,Svensson TH

更新日期：1986-06-04 00:00:00

abstract：:Transplanted embryonic stem (ES) cells can be integrated into the retinas of adult mice as well-differentiated neuronal cells. However, the integrated ES cells also have a tumorigenic effect just because they have the ability for multipotential differentiation to various types of tissues. Thus, control of neoplastic p...

journal_title：Brain research

authors： Hara A,Niwa M,Kumada M,Aoki H,Kunisada T,Oyama T,Yamamoto T,Kozawa O,Mori H

更新日期：2006-04-26 00:00:00

abstract：:Motoneurons in the lumbar spinal cord of chick embryos 6 days old, the age when their cell death starts, were labeled in vivo by retrograde axonal transport of horseradish peroxidase (HRP) and then cultured as cord fragments or isolated cells. In Eagle's minimum essential medium with no additives, spinal cord cells su...

journal_title：Brain research

authors： Tanaka H,Obata K

更新日期：1983-09-01 00:00:00

abstract：:Anorexia nervosa is associated with vasopressin, oxytocin and serotonin abnormalities. Because of the relationship between exercise and anorexia nervosa, we explored the weight-loss syndrome produced by wheel running in food-deprived rats. Its effects on regional vasopressin and oxytocin concentrations were determined...

journal_title：Brain research

authors： Aravich PF,Rieg TS,Ahmed I,Lauterio TJ

更新日期：1993-05-28 00:00:00

abstract：:Postsynaptic potentials were evoked in neostriatal neurons by stimulation of the ipsilateral and contralateral medial agranular frontal cortical field (AGm) in the rat. This cortical region is known to project bilaterally to the dorsal lateral head of the caudate-putamen of rats. Ipsilateral stimulation of AGm should ...

journal_title：Brain research

authors： Wilson CJ

更新日期：1986-03-05 00:00:00

abstract：:The present study was undertaken in order to study the rate of maturation of the cochlear action potential sensitivity, latency, and tuning curves for various stimulus frequencies and to correlate the development of latency and frequency selectivity with threshold development. This study showed a two-stage model of ma...

journal_title：Brain research

authors： Puel JL,Uziel A

更新日期：1987-12-15 00:00:00

abstract：:A novel gold phosphate complex called Black-Gold II with improved myelin staining properties has been developed. It differs from its predecessor, Black-Gold, in that it is highly water soluble at room temperature. This unique physical property confers a number of advantages for the high resolution staining of myelinat...

journal_title：Brain research

authors： Schmued L,Bowyer J,Cozart M,Heard D,Binienda Z,Paule M

更新日期：2008-09-10 00:00:00

abstract：:Serotonin (5HT) is thought to reset the biological clock in the suprachiasmatic nuclei (SCN) in vitro through a postsynaptic 5HT-1a receptor. Thus we examined 5HT receptor gene expression in the SCN by in situ hybridization. On film autoradiograms, 5HT-1c receptor mRNA showed intense SCN hybridization, while 5HT-1b re...

journal_title：Brain research

authors： Roca AL,Weaver DR,Reppert SM

更新日期：1993-04-09 00:00:00

abstract：:The hypoalgesic effects of lesions in the rat spinal trigeminal complex at the levels of subnucleus interpolaris and caudal subnucleus oralis were investigated. Lesions of the trigeminal tract, nucleus, or adjacent reticular formation resulted in significant elevations in escape latencies to noxious thermal stimulatio...

journal_title：Brain research

authors： Pickoff-Matuk JF,Rosenfeld JP,Broton JG

更新日期：1986-09-24 00:00:00

abstract：:The distinction between neural mechanisms of explicit and implicit expressions of memory has been well studied at the retrieval stage, but less at encoding. In addition, dissociations obtained in many studies are complicated by methodological difficulties in obtaining process-pure measures of different types of memory...

journal_title：Brain research

authors： Meng Y,Ye X,Gonsalves BD

更新日期：2014-10-17 00:00:00

abstract：:The localization of the glycine cleavage system was examined in the rat brain by immunohistochemistry using an antibody to P-protein (a constituent of the system). In all sites studied, the enzyme was confined to the astrocytes. The intensity of astrocyte staining varied in different brain regions, with the strongest ...

journal_title：Brain research

authors： Sato K,Yoshida S,Fujiwara K,Tada K,Tohyama M

更新日期：1991-12-13 00:00:00

abstract：:Murine urocortin 3 (mUcn 3), a member of the corticotropin releasing factor (CRF) peptide family, was recently identified. Of known agonists, this neuropeptide displays the highest degree of selectivity in binding to the CRF(2) receptor. These experiments sought to test the hypothesis that CRF(2) receptors have a role...

journal_title：Brain research

authors： Valdez GR,Zorrilla EP,Rivier J,Vale WW,Koob GF

更新日期：2003-08-08 00:00:00

abstract：:Although there are several reports on the alteration of intracellular signal transduction during heat shock in somatic cells, the long term effects of heat shock on neuronal cells remain unknown. In this report, we investigated cyclic AMP (cAMP) accumulation and the expression of heat shock proteins following heat sho...

journal_title：Brain research

authors： Zensho H,Nishida A,Shimizu M,Uchitomi Y,Yamawaki S

更新日期：1998-04-20 00:00:00

abstract：:The opiate antagonist, naloxone, produces dose-dependent biphasic changes in clinical pain. The mechanism of the analgesia produced by low dose naloxone is unknown. To study the analgesic effect of naloxone, we have used a programmable infusion pump, which eliminates placebo-induced endorphin-mediated analgesia, to ad...

journal_title：Brain research

authors： Levine JD,Gordon NC

更新日期：1986-02-19 00:00:00

abstract：:Amyloid beta-protein (A beta) is the major protein of cerebrovascular and plaque amyloid in Alzheimer's disease (AD). Extensive evidence has demonstrated abnormal protein phosphorylation in this disease. We investigated the effect of synthetic A beta with the amino-acid sequence corresponding to cerebrovascular A beta...

journal_title：Brain research

authors： Chauhan A,Chauhan VP,Murakami N,Brockerhoff H,Wisniewski HM

更新日期：1993-11-26 00:00:00

abstract：:The effects of acute ethanol exposure of chick spinal cord neurons were studied in tissue culture, using whole-cell voltage-clamp techniques. Results indicate that ethanol produces a persistent increase in the sensitivity of spinal neurons to GABA and glycine, with no change in input resistance or resting membrane pot...

journal_title：Brain research

authors： Celentano JJ,Gibbs TT,Farb DH

更新日期：1988-07-12 00:00:00

abstract：:At a physiologically relevant concentration (1.25 microM), aluminum had an activating effect on oligodendrocyte cell cultures, similar to that previously reported for other cell types. G protein-linked signal transduction was stimulated as indicated by enhanced production of IP3, and protein synthesis was increased. A...

journal_title：Brain research

authors： Golub MS,Zhang W,Keen CL,Goldkorn T

更新日期：2002-06-21 00:00:00

abstract：:The dopamine transporter from rat caudate-putamen was photolabeled with [125I]DEEP as previously described. Treatment of photolabeled membranes with neuraminidase and N-glycanase reduced the molecular weight of the [125I]DEEP photolabeled dopamine transporter complex, whereas treatment with alpha-mannosidase had no ef...

journal_title：Brain research

authors： Lew R,Grigoriadis D,Wilson A,Boja JW,Simantov R,Kuhar MJ

更新日期：1991-01-25 00:00:00

abstract：:Protein phosphatases (PPs) regulate many substrates implicated in learning and memory. Conditioned taste aversion (CTA) learning, in which animals associate a novel taste paired with a toxin and subsequently avoid the taste, is dependent on several serine/threonine phosphatase substrates and the PP1-binding protein sp...

journal_title：Brain research

authors： Oberbeck DL,McCormack S,Houpt TA

更新日期：2010-08-12 00:00:00