Abstract：
:At a physiologically relevant concentration (1.25 microM), aluminum had an activating effect on oligodendrocyte cell cultures, similar to that previously reported for other cell types. G protein-linked signal transduction was stimulated as indicated by enhanced production of IP3, and protein synthesis was increased. At this concentration Al did not promote cell damage but did enhance oxidative effects initiated by reactive oxygen species. Both AlCl(3) and Al transferrin (AlTf) had similar actions at equimolar concentrations. In vivo, physiological Al ion may act by common cellular pathways in diverse cell types. These effects may be relevant to Al toxicological, pharmacological (immunoadjuvant), and physiological effects.
journal_name
Brain Resjournal_title
Brain researchauthors
Golub MS,Zhang W,Keen CL,Goldkorn Tdoi
10.1016/s0006-8993(02)02597-0subject
Has Abstractpub_date
2002-06-21 00:00:00pages
82-90issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899302025970journal_volume
941pub_type
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