Abstract：
:Until now, there has been no effective therapy for chronic sensorineural hearing impairment. This study investigated the role of bone marrow cells (BMCs) in cochlear dysfunction. BALB/c mice (2 months of age), a non-presbycusis-prone mouse strain, were lethally irradiated and then transplanted with BMCs from SAMP1 mice (2 months of age), a presbycusis-prone mouse strain. Acceleration of age-related hearing loss, early degeneration of spiral ganglion cells (SGCs) and impairment of immune function were observed in the recipient mice as well as in the SAMP1 mice. However, no spiral ganglion cells of donor (SAMP1) origin were detected in the recipient mice. These results indicated that accelerated presbycusis, cochlear pathology, and immune dysfunction of SAMP1 mice can be transferred to BALB/c recipient mice using allogeneic bone marrow transplantation (BMT). However, although the BMCs themselves cannot differentiate into the spiral ganglion cells (SGCs), they indirectly cause the degeneration of the SGCs. Further studies into the relationship between the inner ear cells and BMCs are required.
journal_name
Brain Resjournal_title
Brain researchauthors
Baba S,Iwai H,Inaba M,Kawamoto K,Omae M,Yamashita T,Ikehara Sdoi
10.1016/j.brainres.2006.08.074subject
Has Abstractpub_date
2006-11-20 00:00:00pages
93-9issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(06)02597-2journal_volume
1120pub_type
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