Abstract:
:Near-total dopamine-depleting brain lesions produced in 3-day-old rats by intracerebroventricular injection of the neurotoxin 6-hydroxydopamine led to pronounced increases in striatal serotonin (5-HT) and 5-hydroxyindoleacetic acid contents 1-8 months later. This effect was associated with an increase in in vitro high affinity 5-HT uptake, suggesting that proliferation of new serotonergic terminals had occurred within the striatum. No such effect was obtained when comparable brain lesions were produced in adult rats.
journal_name
Brain Resjournal_title
Brain researchauthors
Stachowiak MK,Bruno JP,Snyder AM,Stricker EM,Zigmond MJdoi
10.1016/0006-8993(84)90665-6subject
Has Abstractpub_date
1984-01-16 00:00:00pages
164-7issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(84)90665-6journal_volume
291pub_type
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