Apparent sprouting of striatal serotonergic terminals after dopamine-depleting brain lesions in neonatal rats.

Abstract:

:Near-total dopamine-depleting brain lesions produced in 3-day-old rats by intracerebroventricular injection of the neurotoxin 6-hydroxydopamine led to pronounced increases in striatal serotonin (5-HT) and 5-hydroxyindoleacetic acid contents 1-8 months later. This effect was associated with an increase in in vitro high affinity 5-HT uptake, suggesting that proliferation of new serotonergic terminals had occurred within the striatum. No such effect was obtained when comparable brain lesions were produced in adult rats.

journal_name

Brain Res

journal_title

Brain research

authors

Stachowiak MK,Bruno JP,Snyder AM,Stricker EM,Zigmond MJ

doi

10.1016/0006-8993(84)90665-6

subject

Has Abstract

pub_date

1984-01-16 00:00:00

pages

164-7

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(84)90665-6

journal_volume

291

pub_type

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