NO activates the olfactory cyclic nucleotide-gated conductance independent from cGMP in isolated rat olfactory receptor neurons.

Abstract:

:Nitric oxide (NO) is a putative neuronal messenger in the olfactory epithelium. We analysed the electrical responses of rat olfactory receptor neurones to NO stimulation in the whole-cell patch clamp mode and found that NO activates the cyclic nucleotide-gated conductance, independent from cyclic GMP. As NO may also open calcium-dependent potassium channels and raise cyclic GMP levels, it appears to act as a complex modulator of olfactory receptor neuron physiology in vivo.

journal_name

Brain Res

journal_title

Brain research

authors

Schmachtenberg O,Diaz J,Bacigalupo J

doi

10.1016/s0006-8993(03)02990-1

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

146-50

issue

1

eissn

0006-8993

issn

1872-6240

pii

S0006899303029901

journal_volume

980

pub_type

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