Abstract：
:The specific binding of [3H]kainic acid to hippocampal membranes was examined autoradiographically in rats kindled by tetanic stimulation of the amygdala or angular bundle. One day after the last of 3 class 4-5 kindled seizures, the specific binding of [3H]kainic acid in stratum lucidum of area CA3 was 47-61% less than in electrode-implanted unstimulated controls. Specific binding in the inner third of the dentate molecular layer was reduced to a lesser degree. These observations demonstrate that kainic acid receptors are down-regulated by kindling stimulation.
journal_name
Brain Resjournal_title
Brain researchauthors
Savage DD,Nadler JV,McNamara JOdoi
10.1016/0006-8993(84)90274-9subject
Has Abstractpub_date
1984-12-03 00:00:00pages
128-31issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(84)90274-9journal_volume
323pub_type
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