Abstract：
:To determine the presence and distribution of cerebrovascular Abeta production we investigated amyloid beta precursor protein (AbetaPP)-mRNA expression by RNA in situ hybridization in patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type, Alzheimer disease and controls. In all subjects, AbetaPP-mRNA was expressed in endothelial cells, smooth muscle cells, adventitial cells and brain pericytes and/or perivascular cells. Meningeal cells also expressed AbetaPP-mRNA. AbetaPP was detected in endothelial cells, smooth muscle cells and adventitial cells. The demonstration of AbetaPP-mRNA at all vascular sites where amyloid formation can occur supports an important contribution of locally derived Abeta to cerebrovascular amyloidosis.
journal_name
Brain Resjournal_title
Brain researchauthors
Natté R,de Boer WI,Maat-Schieman ML,Baelde HJ,Vinters HV,Roos RA,van Duinen SGdoi
10.1016/s0006-8993(99)01361-xsubject
Has Abstractpub_date
1999-05-15 00:00:00pages
179-83issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(99)01361-Xjournal_volume
828pub_type
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