Abstract：
:Dopamine neurons are overstimulated by drugs of abuse and suffer molecular alterations that lead to addiction behavior. Nurr1 is a transcription factor crucial for dopamine neurons survival and dopamine production, activating the transcription of key genes like tyrosine hydroxylase (TH). Interestingly, nuclear factor-kappa B (NF-κB) has emerged as a new Nurr1 partner in response to inflammatory stimulus. In this study we evaluated the effects of single and repeated amphetamine administration in the expression of Nurr1 and the NF-κB p65 subunit in the rat ventral tegmental area (VTA). We found that acute amphetamine treatment increased Nurr1, p65 and TH protein levels in the VTA. On the other hand, chronic amphetamine treatment decreased Nurr1 and p65 protein levels, but TH was unchanged. Mammalian reporter assays in cell lines showed that p65 represses Nurr1 transcriptional activity in an artificial promoter driven by Nurr1 response elements and in the native rat TH promoter. These results indicate that Nurr1 and NF-κB p65 factors are involved in the adaptive response of dopamine neurons to psychostimulants and that both transcription factors could be regulating Nurr1-dependent transactivation in the VTA.
journal_name
Brain Resjournal_title
Brain researchauthors
Arredondo C,González M,Andrés ME,Gysling Kdoi
10.1016/j.brainres.2016.09.031subject
Has Abstractpub_date
2016-12-01 00:00:00pages
14-20eissn
0006-8993issn
1872-6240pii
S0006-8993(16)30667-9journal_volume
1652pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The role of thyrotropin releasing hormone (TRH) in the dorsal vagal complex (DVC) in mediating the enhanced gastric contractility induced by glutamate (100 pmol) microinjected into the raphe pallidus (Rpa) was investigated in urethane-anesthetized rats acutely implanted with miniature strain gauge force transducers on...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91035-9
更新日期：1994-02-14 00:00:00
abstract：:A small, unilateral, penetrating wound was placed in the dorsolateral portion of the lumbosacral spinal cord in immature rats. Although this wound did not extend into the central canal area, some cells forming the walls of this canal underwent proliferative activity as demonstrated by [3H]thymidine autoradiography. Th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90783-0
更新日期：1980-11-10 00:00:00
abstract：:We recently reported raphe neurones which frequently fired spikes in short bursts. However, the action potentials were broad and the neurones fired in a slow and regular pattern, suggesting they were an unusual type of 5-hydroxytryptamine (5-HT) neurone. In the present study, we investigated whether these putative bur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00869-4
更新日期：1996-11-18 00:00:00
abstract：:The purpose of this study is to reveal whether the application of immunohistochemical examinations to the peripheral nervous system (PNS) can be a reliable method for the quantitative analysis of the blood-nerve barrier (BNB) and the relationship between restoration of BNB and nerve regeneration. Sciatic nerves in rat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.10.067
更新日期：2004-03-19 00:00:00
abstract：:Qualitative and computer-assisted analyses were performed on Golgi-impregnated neurons which were serially reconstructed in 3 dimensions. Analysis of the temporal pattern of growth indicated that the initial outgrowth, formation of the adult number of dendrites and virtually all dendritic branching occurred in the pre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90192-6
更新日期：1986-01-01 00:00:00
abstract：:The neurotoxic compound 2,5-hexanedione (2,5-HD) causes an axonopathy characterized by the presence of neurofilament (NF)-containing enlargements in the preterminal segments of central and peripheral axons. The 2,5-HD axonopathy is a good model for human acquired and inherited giant axonal neuropathies. Recently, we r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90067-x
更新日期：1989-07-10 00:00:00
abstract：:The cockroach can reduce the amount of sensory activity received by its CNS from the cerci, paired wind-responsive appendages. This reduction is produced by medial displacement of the cerci, a movement the animal performs naturally during flying. We demonstrate here that this sensory reduction significantly reduces ac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91009-8
更新日期：1988-02-09 00:00:00
abstract：:The behavioral effects of lesions of the nucleus basalis magnocellularis (NBM) on two spatial discrimination tasks (place navigation and cross maze) were examined in the rat. These tasks were designed to test reference memory. Lesions by bilateral injection of ibotenic acid into the NBM led to a severe and permanent i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90079-0
更新日期：1988-07-12 00:00:00
abstract：:Opioid modulation of ingestion includes general opioid antagonism of deprivation-induced water intake and intake of sucrose and saccharin solutions. Previous studies using selective subtype antagonists indicated that opioid effects upon deprivation-induced water intake occurred through the mu2 receptor and that opioid...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91274-v
更新日期：1993-08-06 00:00:00
abstract：:Intracisternal (i.c.) administration of the glutamate-receptor antagonist kynurenate to halothane-anesthetized rats (paralyzed, ventilated) produced an initial hypertension associated with an increase in lumbar sympathetic nerve discharge. Kynurenate (i.c.) blocked or greatly reduced all sympathetic reflexes investiga...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91320-0
更新日期：1988-01-12 00:00:00
abstract：:Recent experimental data have shown that hyperbaric oxygen therapy (HBOT) was associated increased Bcl-2 expression at the injury site that correlated with reduced apoptosis. We hypothesized that HBOT mediated enhancement of Bcl-2 expression and increased intracellular oxygen bio-availability may both contribute to pr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.04.078
更新日期：2008-07-24 00:00:00
abstract：:Regeneration of descending supraspinal projections were identified in adult goldfish following administration of HRP to different levels of the spinal cord. While in the untreated normal fish 17 nuclei were shown to project into the spinal cord, only 11 of them seem to have participated in the process of regeneration....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90159-k
更新日期：1993-08-27 00:00:00
abstract：:The linear nucleus (Li) is a prominent cell group in the caudal hindbrain, which was first described in a study of cerebellar afferents in the rat by [Watson, C.R.R., Switzer, R.C. III, 1978. Trigeminal projections to cerebellar tactile areas in the rat origin mainly from N. interpolaris and N. principalis. Neurosci. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.02.068
更新日期：2009-05-19 00:00:00
abstract：:The involvement of bulbospinal pathways in the antinociceptive effect of clomipramine in experimental pain was studied. The antinociceptive effect of the antidepressant (0.5 mg/kg), intravenously injected, was evaluated after a unilateral lesion of the dorsolateral funiculus. The results showed that this effect was su...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00826-c
更新日期：1995-10-16 00:00:00
abstract：:With the aim of determining a possible role of the entorhinal cortex (EC) in the processing of olfactory information, its electrical activity was recorded during different types of odour sampling behaviour. The EC spontaneous field potentials (EEGs) were related to those recorded simultaneously from the more rostrally...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91506-0
更新日期：1989-01-30 00:00:00
abstract：:Recently developed antisera selective for angiotensin Type 2 (AT2) receptors were used to localize AT2 receptors in rat brain by immunohistochemistry. While the results from these experiments were largely consistent with previous autoradiographic and radioligand binding analyses of AT2 receptor populations in brain, t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90794-3
更新日期：1994-10-31 00:00:00
abstract：:The present study was designed to determine the types of acetylcholine receptors involved in the initiation of epileptic seizures from the zona incerta and surrounding structures by cholinergic stimulation in rats. Unilateral intracerebral microinjection of the mixed muscarinic and nicotinic agonist carbachol (3 micro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90017-5
更新日期：1994-04-18 00:00:00
abstract：:Distribution and time course of the occurrence of "dark" neurons were compared with the EEG activity and behavior of rats during 4-aminopyridine (4-AP) induced epileptic seizures. A crystal of the K(+) channel blocker 4-AP (0.5 mg/kg) was placed onto the exposed parieto-occipital cortex of Halothane-anesthetized rats ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.06.044
更新日期：2008-09-04 00:00:00
abstract：:We sought to determine whether the global increase in regional cerebral blood flow (rCBF) produced by electrical stimulation of the rostral cerebellar fastigial nucleus (FN) is a consequence of excitation of intrinsic neurons of the FN or of axons of fibers passing through or projecting into it. Studies were conducted...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90312-0
更新日期：1989-10-23 00:00:00
abstract：:Previous evidence suggests that preterm newborns with intrauterine growth restriction (IUGR) have specific neurostructural and neurodevelopmental anomalies, but it is unknown whether these effects persist in early childhood. We studied a sample of 18 preterm IUGR, 15 preterm AGA - born between 26 and 34 weeks of gesta...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.01.032
更新日期：2011-03-25 00:00:00
abstract：:Dopamine-containing amacrine cells of rhesus monkey were found everywhere outside of the foveola in whole, flat retinas by the formaldehyde-glutaraldehyde fluorescent method. There were about 7500 such cells in a single retina and their density, determined by cell counts and measured by a nearest neighbor method, was ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91174-0
更新日期：1984-11-19 00:00:00
abstract：:The sublaminar binding profiles of (D-Ala-NMe-Phe-Gly-ol)-enkephalin (DAGO), (2-D-penicillamine), 5-D-penicillamine)-enkephalin (DPDPE), and dynorphin A(1-8) (DYN) were studied in the CA1 subfield and dentate gyrus of rat hippocampal formation. Binding was assayed on cryomicrotome sections using coverslip autoradiogra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91215-2
更新日期：1988-09-13 00:00:00
abstract：:The aim of the present study was to determine differences in cortical processing of consonant-vowel syllables and acoustically matched non-speech sounds, as well as novel human and nonhuman sounds. Event-related potentials (ERPs) were recorded to vowel, vowel duration, consonant, syllable intensity, and frequency chan...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.02.052
更新日期：2010-04-23 00:00:00
abstract：:To assess the role of calcitonin gene-related peptide (CGRP) within the trigeminal subnucleus caudalis (Vc) on adrenal and autonomic function, microinjections were directed at different laminae of Vc in chloralose-anesthetized cats. Microinjections of CGRP (5 pmol, 100 nl) into laminae I-II increased significantly the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90713-6
更新日期：1991-08-30 00:00:00
abstract：:We investigated the electrophysiological properties of the area postrema neurons in acutely prepared rat brain slices using the whole-cell patch-clamp technique. Two different types of transient outward potassium current (I(to)), fast and slow, were found in the area postrema. Both the decay time constant and rise tim...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02651-3
更新日期：2002-06-28 00:00:00
abstract：:Parkinson's disease is characterized by a loss of dopaminergic neurons in the substantia nigra and, in the most severe cases, by degeneration of mesopontine cholinergic neurons. In a monkey model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine we report that, despite a severe loss of dop...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90088-5
更新日期：1993-10-08 00:00:00
abstract：:The molecular mechanisms regulating the retrograde axonal transport of nerve growth factor (NGF) are currently unknown. This study identifies some of the signalling events involved. The phosphoinositide 3-kinase (PI3-kinase) inhibitor wortmannin (1 nmol/eye) irreversibly inhibits the amount of 125I-betaNGF retrogradel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00396-5
更新日期：1998-07-06 00:00:00
abstract：:The effects of medial septal lesions on latent inhibition (LI) were assessed in a conditioned taste aversion paradigm. Animals were tested in a LI paradigm 2 weeks after receiving medial septal or sham lesions. The LI paradigm involved a pre-exposure phase in which water-deprived rats were allowed access to either wat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03192-9
更新日期：2001-02-02 00:00:00
abstract：:The ability of heterotopic noxious stimuli to inhibit the activity of dorsal horn convergent neurones was investigated in both intact anesthetized, and spinal unanesthetized rats. Forty-four convergent neurones in lumbar dorsal horn were recognized by their ability to respond to both noxious and non-noxious natural st...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90412-2
更新日期：1983-09-19 00:00:00
abstract：:Frequency modulation (FM) is an important building block of complex sounds that include speech signals. Exploring the neural mechanisms of FM coding with computer modeling could help understand how speech sounds are processed in the brain. Here, we modeled the single unit responses of auditory neurons recorded from th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.04.058
更新日期：2013-11-06 00:00:00
