Abstract：
:Distribution and time course of the occurrence of "dark" neurons were compared with the EEG activity and behavior of rats during 4-aminopyridine (4-AP) induced epileptic seizures. A crystal of the K(+) channel blocker 4-AP (0.5 mg/kg) was placed onto the exposed parieto-occipital cortex of Halothane-anesthetized rats for 40 min. Thereafter, the anesthesia was discontinued and the behavioral signs of the epileptic seizure activity were observed. The presence of "dark" neurons was demonstrated by the sensitive silver method of Gallyas in rats sacrificed at 0, 3 and 6 h after the end of the 4-AP crystal application. The EEG activity was recorded in the rats with longer survival times. The EEG analysis revealed the generalization of the epileptic seizures. We found that the formation of "dark" neurons in the hippocampus and the pontine reticular formation paralleled the generalization of the seizures.
journal_name
Brain Resjournal_title
Brain researchauthors
Baracskay P,Szepesi Z,Orbán G,Juhász G,Czurkó Adoi
10.1016/j.brainres.2008.06.044subject
Has Abstractpub_date
2008-09-04 00:00:00pages
217-28eissn
0006-8993issn
1872-6240pii
S0006-8993(08)01480-7journal_volume
1228pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:An analysis of cellular kinetics during closure of the cranial neural folds in the C57BL mouse at 8 and 9 days gestations was obtained by means of tritiated thymidine autoradiography. At 8 days the short generation time (7.5 h) and high labeling index (61.4%) are evidence of intensive proliferative activity occurring ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(81)90049-3
更新日期：1981-10-01 00:00:00
abstract：:Dorsal root ganglion (DRG) neurons from rat embryos were explanted either alone or with the attached spinal cord (SC). Neuritic processes were mapped out histologically using an intracellular iontophoretic HRP method. Computer reconstructions and morphometric parameters allowed a comparative quantitative analysis of t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90871-6
更新日期：1992-07-03 00:00:00
abstract：:The cholinergic neurotoxin, AF64A-picrylsulfonate, was unilaterally infused into the dorsal hippocampus of Wistar rats (2 nmol/2 microliters/4 min; A 6.2, Ls 1.5, H 6.5, Paxinos and Watson). After 19 days the for immunohistochemical staining of choline acetyltransferase (ChAT). Morphometry and counting of ChAT-immunor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91125-x
更新日期：1986-04-02 00:00:00
abstract：:The effect of suprachiasmatic nucleus (SCN) ablation on rhythms in brain neurotransmitter receptors was studied. In control animals, the rhythms in the number of alpha-adrenergic and benzodiazepine receptors were circadian, whereas the rhythms in beta-adrenergic and acetylcholine receptors were ultradian. SCN ablation...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91533-1
更新日期：1985-02-18 00:00:00
abstract：:The Harderian gland of birds, a major lacrimal gland, contains a large population of lymphoid cells that produce IgA, a significant component of tears. Using histochemical techniques, we have examined the innervation of the gland. There was an extensive acetylcholine-esterase positive fiber network throughout the glan...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91331-9
更新日期：1985-02-25 00:00:00
abstract：:We examined the effects of early epileptiform activity on development of visuocortical receptive fields in the rabbit. Aqueous penicillin was injected twice a day into a cannula implanted over the monocular area of one visual cortex. Drug administration was begun on postnatal day 8-9 and continued until postnatal day ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(81)90113-9
更新日期：1981-04-01 00:00:00
abstract：:Transfer learning is an immanent feature of perceptual learning. Yet, despite the increasingly widespread application of transcranial direct current stimulation (tDCS) to study learning, transfer effects in response to tDCS have not been studied. Therefore, the present study investigated the transfer of tactile acuity...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.03.031
更新日期：2018-06-15 00:00:00
abstract：:Plectin is associated with intermediate filaments, such as glial fibrillary acidic protein (GFAP) and vimentin, which have an important role in the glial reactions after lesions. The present study investigates the plectin immunoreactivity following stab wounds in the cortex and the underlying white matter of adult rat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02399-9
更新日期：2000-02-28 00:00:00
abstract：:An in vitro method has been developed to determine quantitatively the permeability of the perineurium to radiotracers at room temperature. The permeability to [14C]sucrose of the isolated perineurium of the sciatic nerve of the frog, Rana pipiens, was measured at rest length, when the perineurium was stretched and aft...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90244-0
更新日期：1979-09-21 00:00:00
abstract：:A major effect of volatile anesthetics is to reduce excitatory synaptic transmission. In the present study the stimulated release of glutamate under the influence of increasing concentrations of isoflurane was studied in vitro by utilizing hippocampal slices from Wistar rats. Ca(2+)-dependent release was calculated by...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91282-3
更新日期：1994-11-14 00:00:00
abstract：:Near-infrared spectroscopy (NIRS) enables noninvasive measurement of concentration changes of oxy- and deoxy-hemoglobin. The present study investigated cerebral representations of motion illusion by NIRS and examined several experimental procedures to determine an efficient procedure that can shorten the experimental ...
journal_title：Brain research
pub_type： 临床试验,杂志文章
doi：10.1016/j.brainres.2005.11.050
更新日期：2006-03-10 00:00:00
abstract：:Attachment, growth and morphological differentiation of isolated adult rat oligodendrocytes cultured on a naturally produced basement membrane-like extracellular matrix (ECM) occurred much faster than on poly-L-lysine (PLL) coated tissue culture dishes. In each individual trial the cells cultured on ECM exhibited, wit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91049-1
更新日期：1983-05-09 00:00:00
abstract：:Neonatal destruction of nigrostriatal dopamine neurons by cerebroventricular injection of 6-hydroxydopamine (6-OHDA) results in a serotonin (5-HT) hyperinnervation of the rostral neostriatum in adult rat. Quantitative ligand-binding autoradiography was used to compare the density of various 5-HT receptor subtypes in t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90995-y
更新日期：1993-03-26 00:00:00
abstract：:Tourette syndrome (TS) is a childhood-onset tic disorder associated with abnormal development of brain networks involved in the sensory and motor processing. An involvement of immune mechanisms in its pathophysiology has been proposed. Animal models based on active immunization with bacterial or viral mimics, direct i...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2014.04.027
更新日期：2015-08-18 00:00:00
abstract：:The functional organization of projections from the cerebellar subcortical nuclei to the motor cortex through the nucleus ventralis lateralis (VL) of the thalamus was studied using tungsten microelectrodes for stimulation and recordings in acute and chronic cats. The following results were obtained. (1) Microstimulati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90510-7
更新日期：1975-11-07 00:00:00
abstract：:Long-term potentiation (LTP) is a form of synaptic plasticity that may underlie learning and memory. The experiments reported here demonstrate that cocaine blocks the induction of LTP at the excitatory synapses in the CA1 region of the hippocampus, but does not appear to do so by blocking NMDA receptors or channels. O...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91466-6
更新日期：1993-04-16 00:00:00
abstract：:Given that relatively little is known regarding the central control of brown adipose tissue (BAT)-mediated thermogenesis the present study assessed whether the direct pharmacological stimulation of beta- or alpha-adrenergic receptors located on the brown adipocytes would result in a typical thermogenic response follow...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91482-g
更新日期：1991-04-19 00:00:00
abstract：:The primary objective of this study was to test the hypothesis that intravenous administration of autologous bone marrow cells could improve functional recovery after middle cerebral artery occlusion (MCAO) for 45 min in the rat and to determine specific time windows for efficacy. Mononuclear cells from autologous bon...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.09.084
更新日期：2004-05-08 00:00:00
abstract：:To verify whether microtubules are involved in the mechanism of axoplasmic transport in vivo, [3H]leucine was injected into ventral horns of rats, and 3 h later Ca2+ or other drugs injected into sciatic nerves. The injection of 50-200 mM Ca2+, raising intra-axoplasmic Ca2+ levels, blocked transport above the intraneur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90514-7
更新日期：1986-03-26 00:00:00
abstract：:Using a double-label immunofluorescence method, we analyzed the time course of the appearance of Fos and Jun in the nuclei of supraoptic nucleus (SON) neurons following intraperitoneal injection of hypertonic saline. Fos and Jun immunostaining appeared within 30 min, peaked at 90-120 min, and disappeared 4-5 h later. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01216-4
更新日期：1997-01-23 00:00:00
abstract：:Acupuncture is widely used to relieve pain; however, the mechanism underlying electroacupuncture analgesia (EAA) during inflammatory pain is unclear. We investigated whether endogenous peripheral opioid receptors participated in EAA during hyperalgesia elicited by carrageenan-induced inflammation. Moreover, we investi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.08.014
更新日期：2010-10-08 00:00:00
abstract：:Microtubule-associated protein 1B (MAP1B) is expressed at high levels during development of the nervous system and is localized primarily in neurons while specific phosphorylated isoforms of MAP1B are localized exclusively in growing axons. The levels of MAP1B are down regulated in most regions of the adult CNS, but r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01148-8
更新日期：1999-03-27 00:00:00
abstract：:The chemokines CCL2 and CCL7 are upregulated in the brain during several neurodegenerative and acute diseases associated with infiltration of peripheral leukocytes. Astrocytes can respond to inflammatory cytokines like IL-1beta and TNF-alpha by producing chemokines. This study aims to test the ability of IL-1beta and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.06.081
更新日期：2009-09-01 00:00:00
abstract：:Several studies have demonstrated that the blood-brain barrier (BBB) (dynamic cellular complex composed by brain capillary endothelial cells (BCECs) and surrounded by astrocytic end feet and pericytes) regulates the exchanges of amyloid β (Aβ) peptide between the blood and the brain. Deregulation of these exchanges se...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.10.047
更新日期：2015-01-12 00:00:00
abstract：:The subfornical organ (SFO), a neuroendocrine structure implicated in saltwater homeostasis, contains secretory structures histochemically similar to those in the neurohypophysis. Because of these morphological similarities, we compared levels of vasopressin (vp) in the SFO area and the adjacent hippocampal commissure...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90458-4
更新日期：1978-01-27 00:00:00
abstract：:While much has been elucidated about the hypothalamic controls of energy balance, the epidemic of obesity continues to escalate. Recent work has suggested that extra-hypothalamic central nervous system structures may play a previously un-appreciated role in the control of ingestive behavior and body weight regulation....
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2010.06.009
更新日期：2010-09-02 00:00:00
abstract：:The effects of brain and meningeal extracts from chick embryos on the proliferation of cultured neuroblasts from chick embryo cerebral hemispheres were studied. Morphological observations, counts of the cultured neurons, determination of DNA and protein contents as well as [3H]thymidine incorporation measurements were...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(81)90073-0
更新日期：1981-06-01 00:00:00
abstract：:Ventilation is peripherally controlled by afferent activity arising from the peripheral chemoreceptors. In the rat, chemosensory activity is conveyed to the central nervous system through axons of neurons located in the nodose-petrosal-jugular-complex. These neurons have distinct electrophysiological properties, inclu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.08.027
更新日期：2016-10-15 00:00:00
abstract：:Coupling between lumbar motoneurons in the isolated frog spinal cord was studied by using intracellular recordings and intracellular injections of Lucifer Yellow CH. Physiological studies revealed intra- and intersegmental, short latency electrical interactions between many motoneurons. Injections of Lucifer Yellow in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90721-7
更新日期：1983-09-12 00:00:00
abstract：:Evidence exists that repeated injections of melatonin in rather large doses inhibit sexual performance in male rats. In contrast, systemic injection of small doses of this hormone stimulates sexual activity of normal male rats. In these experiments, systemic acute administration of melatonin in small doses (10-100 mic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02715-3
更新日期：2000-09-29 00:00:00
