Depression of activities of dorsal horn convergent neurones by propriospinal mechanisms triggered by noxious inputs; comparison with diffuse noxious inhibitory controls (DNIC).

Abstract:

:The ability of heterotopic noxious stimuli to inhibit the activity of dorsal horn convergent neurones was investigated in both intact anesthetized, and spinal unanesthetized rats. Forty-four convergent neurones in lumbar dorsal horn were recognized by their ability to respond to both noxious and non-noxious natural stimuli and by their characteristic responses corresponding to A- and C-fibre activity following electrical stimulation of their cutaneous excitatory receptive fields on the ipsilateral hindpaw. The application of a sustained pinch to the excitatory receptive field resulted in an initial phasic activation of the neurone, which adapted to a stable tonic level of activity (mean 31.8 +/- 2.2 spikes/s). The levels of activity produced in this fashion were not appreciably different between the two types of preparation. In the intact anesthetized rat, the tonic activity produced by the sustained pinch could be strongly depressed by noxious conditioning stimuli applied to various parts of the body for all 10 neurones studied: heating the tail or pinching the contralateral hindpaw, the tail or a forepaw during 30 s each resulted in comparable inhibitions which had mean values in the order of 80% and which were always marked by post-effects lasting for upwards of 30 s. These inhibitory effects have been called Diffuse Noxious Inhibitory Controls (DNIC). In the spinal unanesthetized rat, the tonic activity was depressed to some extent by the same conditioning stimuli, for only 16/34 neurones studied. By comparison with the intact animals these inhibitions were weak, adapted to base-line levels within 30 s and were more marked for conditioning stimuli applied to structures proximal (tail, contralateral hindpaw) to the excitatory receptive field than for stimuli applied more distally (forepaws). The differences between the inhibitions found in the intact and spinal preparations were subsequently confirmed in a series of experiments in which single convergent neurones were studied before and after the pharmacological blocking of the cervical spinal cord in anaesthetized rats. The results in the spinal preparations provide evidence for the existence of some propriospinal modulatory processes, triggered by the onset of noxious stimulation and acting on convergent neurones. These processes appear to be different from those mediating DNIC, which have been shown to involve supraspinal structures, to concern all convergent neurones, to be very potent and associated with long-lasting post-effects whether the conditioning noxious stimuli are applied to parts of the body proximal or distal to the excitatory receptive field.

journal_name

Brain Res

journal_title

Brain research

authors

Cadden SW,Villanueva L,Chitour D,Le Bars D

doi

10.1016/0006-8993(83)90412-2

subject

Has Abstract

pub_date

1983-09-19 00:00:00

pages

1-11

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(83)90412-2

journal_volume

275

pub_type

杂志文章
  • Role of V1a vasopressin receptors in the control of aggression in Syrian hamsters.

    abstract::The present study investigated the hypothesis that social isolation increases aggression by increasing the number of V1a vasopressin receptors in the anterior hypothalamus (AH). Male hamsters were randomly assigned to a group that was allowed to interact with a small nonaggressive hamster three times each week for 3 w...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2005.12.081

    authors: Albers HE,Dean A,Karom MC,Smith D,Huhman KL

    更新日期:2006-02-16 00:00:00

  • Neuromuscular patterns of stereotypic hindlimb behaviors in the first two postnatal months. I. Stepping in normal kittens.

    abstract::Neuromuscular patterns associated with the development of hindlimb stepping behaviors were studied from birth to postnatal day 60 in normal kittens. Hindlimb muscles were chronically implanted with EMG electrodes at birth to characterize interlimb coordination and intralimb synergies during development of overground a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(88)90084-3

    authors: Bradley NS,Smith JL

    更新日期:1988-01-01 00:00:00

  • Electrical stimulation of the posterior insula induces mechanical analgesia in a rodent model of neuropathic pain by modulating GABAergic signaling and activity in the pain circuitry.

    abstract::The insula has emerged as a critical target for electrical stimulation since it influences pathological pain states. We investigated the effects of repetitive electrical stimulation of the insular cortex (ESI) on mechanical nociception, and general locomotor activity in rats subjected to chronic constriction injury (C...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147237

    authors: Alonso-Matielo H,Gonçalves ES,Campos M,Oliveira VRS,Toniolo EF,Alves AS,Lebrun I,de Andrade DC,Teixeira MJ,Britto LRG,Hamani C,Dale CS

    更新日期:2021-01-02 00:00:00

  • Norepinephrine transmitter metabolite induces apoptosis in differentiated rat pheochromocytoma cells.

    abstract::3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the monoamine oxidase A metabolite of norepinephrine and epinephrine. DOPEGAL, but not other metabolites, kills differentiated PC-12 cells. However, the type of DOPEGAL induced cell death, whether necrosis or apoptosis, is not known. To determine the type of cell death tr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00447-2

    authors: Burke WJ,Schmitt CA,Miller C,Li SW

    更新日期:1997-06-20 00:00:00

  • The proportion of neurons in the rat neostriatum that project to the substantia nigra demonstrated using horseradish peroxidase conjugated with wheatgerm agglutinin.

    abstract::Following the injection of small volumes of horseradish peroxidase conjugated with wheatgerm agglutinin into the substantia nigra of the rat, a high proportion of the total neuronal population in parts of the ipsilateral neostriatum was retrogradely labelled with horseradish peroxidase. Quantitative estimates in 1-mic...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)91222-1

    authors: Bolam JP,Powell JF,Totterdell S,Smith AD

    更新日期:1981-09-14 00:00:00

  • Human Thy-1: expression on the cell surface of neuronal and glial cells.

    abstract::The Thy-1 antigen is a cell surface glycoprotein found in neural tissue of all mammalian species so far studied. The distribution and amount of this antigen has been measured on 4 human neuronal and 2 neuroglial cell lines and on fresh tumour cells of neuronal origin. In 3 out of 4 neuronal lines (LAN-1, TR14, CHP 212...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(82)90727-2

    authors: Kemshead JT,Ritter MA,Cotmore SF,Greaves MF

    更新日期:1982-03-25 00:00:00

  • Quantitative analysis of glutathione in rat central nervous system: comparison of GSH in infant brain with that in adult brain.

    abstract::Reduced glutathione (GSH) plays an important role in cellular protection against damage from free radicals and other electrophiles. GSH in the rat central nervous system was quantitatively analyzed. In adult brain, tissue from the cerebellum and cerebrum had higher GSH levels than that from the brainstem and spinal co...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)90178-e

    authors: Kudo H,Kokunai T,Kondoh T,Tamaki N,Matsumoto S

    更新日期:1990-03-19 00:00:00

  • Neurophysiological abnormalities in cultured dorsal root ganglion neurons from the trisomy-16 mouse fetus, a model for Down syndrome.

    abstract::The trisomy-16 mouse is considered to be a model of human trisomy-21 (Down syndrome). We have examined the electrical membrane properties of cultured dorsal root ganglion (DRG) neurons from normal and trisomy-16 fetuses. Trisomy-16 neurons had significantly accelerated rates of action potential depolarization and repo...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)90678-1

    authors: Ault B,Caviedes P,Rapoport SI

    更新日期:1989-04-17 00:00:00

  • Noradrenergic innervation of serotonergic neurons in the dorsal raphe: demonstration by electron microscopic autoradiography.

    abstract::In this study, noradrenergic (NE) terminals in the dorsal raphe were identified by [3H]NE electron microscopic (EM) autoradiography. Lesioning of NE terminals by treatment with the selective catecholamine neurotoxin, 6-hydroxydopamine produced a marked decrease in NE-labelled terminals. [3H]5-HT EM autoradiography of ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)90646-6

    authors: Baraban JM,Aghajanian GK

    更新日期:1981-01-05 00:00:00

  • ERP correlates of the incidental retrieval of emotional information: effects of study-test delay.

    abstract::Prior studies indicate that, in tests of recognition memory, ERPs elicited by correctly recognized test items differ according to whether the items were encoded in an emotionally arousing or an emotionally neutral study context. These prior studies employed only a relatively brief (ca. 10 min) retention interval, howe...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.02.082

    authors: Jaeger A,Johnson JD,Corona M,Rugg MD

    更新日期:2009-05-07 00:00:00

  • Postural change and straining induced by distension of the rectum, vagina and urinary bladder of decerebrate dogs.

    abstract::In decerebrate dogs, stimulation of pelvic afferent fibres and distension of the rectum, vagina and urinary bladder brought about a sustained postural change and rhythmic abdominal compression. The posture, which resulted from flexion of the back and stifle joints, extension of the hip joints and lifting of the tail, ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)90223-4

    authors: Fukuda H,Fukai K

    更新日期:1986-08-20 00:00:00

  • A quantitative electron microscopic study on synapse formation in dissociated fetal rat cerebral cortex in vitro.

    abstract::Occipital cortex of 19-day-old fetal rats was dissociated and cultured in vitro for 2-5 weeks in horse serum supplemented Eagle's MEM. The outgrowing neurons rapidly formed a dense network which started to degenerate after 3 weeks in vitro. By means of electron microscopy the numerical development of 6 different categ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(81)90011-0

    authors: Romijn HJ,Mud MT,Habets AM,Wolters PS

    更新日期:1981-07-01 00:00:00

  • Non-linear kinetics of glutamyl-tRNA synthesis catalyzed by high molecular weight complexes from rat brain neuronal cells but not from glial cells.

    abstract::High molecular weight complexes of aminoacyl-tRNA synthetases isolated from rat brain catalyze the formation of glutamyl-tRNA with an initial lag time of the order of 1 min, as previously reported for the formation of glutamyl-tRNA and glutaminyl-tRNA catalyzed by similar complexes from bovine brain (Vadeboncoeur and ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0169-328x(86)90016-1

    authors: Lacoste L,Hertz L,Lapointe J

    更新日期:1986-07-01 00:00:00

  • Amygdaloid input to transiently tyrosine hydroxylase immunoreactive neurons in the bed nucleus of the stria terminalis of the rat.

    abstract::Several studies have reported transient expression of tyrosine hydroxylase in a subpopulation of neurons in the bed nucleus of stria terminalis of preadolescent rats. The tyrosine hydroxylase immunoreactive (TH) neurons, which are of small to medium size and often display a typical bipolar configuration, are confined ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)01175-7

    authors: Beltramino CA,Forbes MS,Swanson DJ,Alheid GF,Heimer L

    更新日期:1996-01-08 00:00:00

  • Swelling of glial cells in lactacidosis and by glutamate: significance of Cl(-)-transport.

    abstract::Swelling of glial and nerve cells is characteristic of brain damage in cerebral ischemia or trauma. The therapeutical efficiency of inhibition of Cl(-)-transport by a novel antagonist, the diuretic torasemide, on cytotoxic swelling of glial cells from lactacidosis, or glutamate was analyzed. Lactacidosis and the inter...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)91218-h

    authors: Staub F,Peters J,Kempski O,Schneider GH,Schürer L,Baethmann A

    更新日期:1993-04-30 00:00:00

  • The plasma membrane of bulk-isolated mature spinal neurons.

    abstract::Large neuronal perikarya isolated in bulk fractions from adult bovine ventral spinal cord and examined by electron microscopy have discontinuities in their plasma membrane. A systematic investigation of the possible causes of the membrane defects indicates that the act of mechanical dissociation of the neurons from th...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(78)90108-7

    authors: Hester S,Capps-Covey P,McIlwain DL

    更新日期:1978-12-22 00:00:00

  • Decreased neuropeptide-converting enzyme activities in cerebrospinal fluid during acute but not chronic phases of collagen induced arthritis in rats.

    abstract::We investigated the effects of collagen II-induced arthritis on two cerebrospinal fluid (CSF) enzymes converting dynorphin A and substance P (SP), namely dynorphin-converting enzyme (DCE) and substance P endopeptidase (SPE). The products generated by these enzymes are the bioactive fragments Leu-enkephalin-Arg6 and su...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90718-o

    authors: Persson S,Post C,Holmdahl R,Nyberg F

    更新日期:1992-05-29 00:00:00

  • Two types of high voltage-activated calcium channels in SH-SY5Y human neuroblastoma cells.

    abstract::Voltage-activated calcium channel currents were recorded from differentiated human neuroblastoma cells. SK-N-SH-SY5Y (SH-SY5Y) line, using patch-clamp techniques. Experimental solutions were designed to suppress sodium and potassium channel currents, and barium ions were used as the charge carrier. Two distinct types ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)91300-h

    authors: Reuveny E,Narahashi T

    更新日期:1993-02-12 00:00:00

  • Maturational changes of amino acid concentration in cerebrospinal fluid of the rat.

    abstract::The cisternal spinal fluid (CF), plasma, and brain stem concentrations of 6 amino acids were measured in suckling rats between birth and one months of age. Each of the amino acids studied had its distinctive maturational pattern of CF concentration. Presumably these amino acids have separate mechanisms of transport fr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(77)90098-1

    authors: Korobkin RK,Cutler RW

    更新日期:1977-01-01 00:00:00

  • Different expression of ubiquitin C-terminal hydrolase-L1 and αII-spectrin in ischemic and hemorrhagic stroke: Potential biomarkers in diagnosis.

    abstract::The two primary categories of stroke, ischemic and hemorrhagic, both have fundamentally different mechanisms and thus different treatment options. These two stroke categories were applied to rat models to identify potential biomarkers that can distinguish between them. Ischemic stroke was induced by middle cerebral ar...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2013.09.051

    authors: Ren C,Zoltewicz S,Guingab-Cagmat J,Anagli J,Gao M,Hafeez A,Li N,Cao J,Geng X,Kobeissy F,Mondello S,Larner SF,Hayes RL,Ji X,Ding Y

    更新日期:2013-12-02 00:00:00

  • Postsynaptic control of lumbar motoneuron excitability during active sleep in the chronic cat.

    abstract::A correlated intracellular and extracellular study of lumbar motoneuron excitability during sleep and wakefulness was performed in the chronic, unanesthetized, undrugged, normally respiring cat. Experiments were designed to reveal the extent to which hypotonia during active sleep in mammals is dependent on postsynapti...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)90836-2

    authors: Morales F,Chase MH

    更新日期:1981-11-30 00:00:00

  • High fat/refined carbohydrate diet enhances the susceptibility to spatial learning deficits in rats exposed to intermittent hypoxia.

    abstract:BACKGROUND:Intermittent hypoxia during sleep (IH), as occurs in sleep disordered breathing (SDB), induces spatial learning deficits associated with regulation of transcription factors associated with learning and memory in the hippocampal CA1 region in rats. high fat refined carbohydrate diet (HF/RC) can induce similar...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.03.046

    authors: Goldbart AD,Row BW,Kheirandish-Gozal L,Cheng Y,Brittian KR,Gozal D

    更新日期:2006-05-23 00:00:00

  • Corticotropin-releasing factor and systemic capsaicin-sensitive afferents are involved in abdominal surgery-induced Fos expression in the paraventricular nucleus of the hypothalamus.

    abstract::We previously reported that abdominal surgery induces Fos expression in specific hypothalamic and medullary nuclei and also causes gastric stasis. The gastric ileus is reduced by systemic capsaicin and abolished by central injection of corticotropin-releasing factor (CRF) antagonist. We studied the influence of system...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(96)01281-4

    authors: Bonaz B,Taché Y

    更新日期:1997-02-14 00:00:00

  • The tuberal lateral hypothalamus is a major target for GABAA--but not GABAB-mediated control of food intake.

    abstract::The lateral hypothalamus (LH) is a site of integration for control mechanisms of feeding behavior as it has extensive reciprocal connections with multiple intrahypothalamic and extrahypothalamic brain areas. Evidence suggests that blockade of ionotropric gamma-aminobutyric acid (GABA) receptors in the LH elicits eatin...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.05.064

    authors: Turenius CI,Charles JR,Tsai DH,Ebersole PL,Htut MH,Ngo PT,Lara RN,Stanley BG

    更新日期:2009-08-04 00:00:00

  • Dorsal pallidum as a functional motor output of the corpus striatum.

    abstract::A major function of the dopamine in the striatum is to control the activity of its efferent systems which contain primarily GABAergic neurons. Direct intracerebral injections of haloperidol into the corpus striatum impaired the performance of rats trained to depress a lever in a sensitive reaction time task. Rats were...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)90186-8

    authors: Amalric M,Koob GF

    更新日期:1989-04-03 00:00:00

  • Binding sites for 125I ET-1, ET-2, ET-3 and vasoactive intestinal contractor are present in adult rat brain and neurone-enriched primary cultures of embryonic brain cells.

    abstract::Binding sites for iodinated endothelin (ET)-2, ET-3 and vasoactive intestinal contractor (VIC) were visualised in the adult rat brain using quantitative autoradiography and have a similar anatomical distribution to that of ET-1 and sarafotoxin S6b. Highest densities of binding sites for all 5 labelled peptides were pr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90201-6

    authors: Davenport AP,Morton AJ

    更新日期:1991-07-19 00:00:00

  • Selective reinnervation of hippocampal area CA1 and the fascia dentata after destruction of CA3-CA4 afferents with kainic acid.

    abstract::Intraventricular injections of kainic acid were used to destroy the hippocampal CA3-CA4 cells, thus denervating the inner third of the molecular layer of the fascia dentata and stratum radiatum and stratum oriens of area CA1. The responses of intact afferents to such lesions were then examined histologically. The hipp...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(80)90825-2

    authors: Nadler JV,Perry BW,Cotman CW

    更新日期:1980-01-20 00:00:00

  • Neural correlates of successful memory retrieval in aging: Do executive functioning and task difficulty matter?

    abstract::The current experiment aimed to explore age differences in brain activity associated with successful memory retrieval in older adults with different levels of executive functioning, at different levels of task demand. Memory performance and fMRI activity during a recognition task were compared between a young group an...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.10.009

    authors: Angel L,Bastin C,Genon S,Salmon E,Fay S,Balteau E,Maquet P,Luxen A,Isingrini M,Collette F

    更新日期:2016-01-15 00:00:00

  • Heterogeneity of neurons in the crustacean X-organ as revealed by intracellular recording and injection of horseradish peroxidase.

    abstract::The intracellular injection technique of HRP with simultaneous recordings of intracellular potential was applied to the crab X-organ-sinus gland peptidergic neurosecretory neurons. At least two classes of neurons were discriminated from the usual type of neurosecretory neurons morphologically as well as electrophysiol...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)90468-3

    authors: Nagano M

    更新日期:1986-01-08 00:00:00

  • Retina-derived microglial cells induce photoreceptor cell death in vitro.

    abstract::In animals with retinal degeneration, the presence of activated microglial cells in the outer retina during the early stages of injury suggests that they may be involved in the ensuing photoreceptor cell death. In the following study, we investigated the effects of rat retina-derived microglial cells on a photorecepto...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)01625-x

    authors: Roque RS,Rosales AA,Jingjing L,Agarwal N,Al-Ubaidi MR

    更新日期:1999-07-31 00:00:00