Abstract：
:Preparations of lysed synaptosomes exhibit a high affinity Ca2+/Mg2+ ATPase and ATP-dependent Ca2+ accumulation activity, with a Km for Ca2+ congruent to 0.5 microM, close to the cytosolic concentration of Ca2+. When these membrane suspensions were incubated with cholinergic agonists muscarine or oxotremorine (1-20 microM), both Ca2+/Mg2+ ATPase and ATP-dependent CA2+ uptake were inhibited in a concentration-dependent fashion. Atropine alone (0.5-1.0 microM) had no effect on either enzyme or uptake activity, but significantly inhibited the actions of both muscarine and oxotremorine. No significant effects by cholinergic agonists or antagonists were seen on fast or slow phase voltage-dependent Ca2+ channels or Na+-Ca2+ exchange. These results suggest that activation of presynaptic muscarinic receptors produce inhibition of two processes required for the buffering of optimal free Ca2+ by the nerve terminal. Activation of presynaptic muscarinic receptors have been reported to reduce the release of ACh from nerve terminals. Alterations in intracellular free Ca2+ may contribute to a reduction in transmitter (ACh) release seen following activation of cholinergic receptors.
journal_name
Brain Resjournal_title
Brain researchauthors
Ross DH,Shreeve SM,Hamilton MGdoi
10.1016/0006-8993(85)90510-4subject
Has Abstractpub_date
1985-03-11 00:00:00pages
39-47issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(85)90510-4journal_volume
329pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Flexion movements induced by cortical stimulation and the associated postural adjustments in bilaterally pyramidotomised cats have been studied by means of an apparatus which measures separately the changes of force under each limb in the upright position of the animal. The results show: (1) The general motor behaviou...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90586-3
更新日期：1978-06-23 00:00:00
abstract：:An interesting feature of the kindling phenomenon relates to the finding that kindling established in one region of the brain may reduce the number of stimulations required to establish the phenomenon in a second region. It has been proposed that this 'transfer' phenomenon reflects the extent to which seizures arising...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00779-8
更新日期：1997-10-10 00:00:00
abstract：:Brief force perturbations were applied 30-120 ms prior to onset of step-tracking forearm movements by normal humans. The perturbations altered the first agonist burst of the movement-related triphasic EMG pattern. Perturbations opposing the movement resulted in an increase in the magnitude of the late part of the firs...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91224-5
更新日期：1981-09-14 00:00:00
abstract：:We investigated the effects of neonatal optic nerve transection on cortical acetylcholinesterase (AChE) activity in hooded rats during postnatal development and following behavioral manipulation after weaning. AChE reaction product was quantified on digitized images of histochemically stained sections in layer IV of p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.12.080
更新日期：2007-03-30 00:00:00
abstract：:A method for selectively labeling the CNS neurons that give rise to zinc-containing axonal boutons is described. Focal intracerebral infusions of selenium anions are used to produce a precipitate (presumably ZnSe) in zinc-containing axonal boutons at the injection site, and within 24-48 h, the precipitate is transport...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90607-d
更新日期：1990-05-07 00:00:00
abstract：:Hypothalamus and frontal cortex beta-adrenergic receptors, as measured by [125I]cyanopindolol binding, were investigated in male rats both after 4 days of acute starvation and after 2 weeks of semistarvation with dietary manipulation. Moreover, to test whether lymphocyte beta 2-adrenergic receptors can be used as a ma...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91519-3
更新日期：1988-03-01 00:00:00
abstract：:The herpes virus suis has been used as a tracer for the pathways in the central nervous system of the rat. The viruses have been inoculated in various peripheral structures innervated by the trigeminal nerve, namely in the cornea by instillation or scarification, in the anterior chamber of the eye by injection and als...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90850-8
更新日期：1983-08-29 00:00:00
abstract：:Nerve growth factor (NGF) and neurotrophin-3 (NT-3) are target-derived proteins that regulate innervating sympathetic neurons. Here, we used western blot analysis to investigate changes in NGF and NT-3 protein in several peripheral tissues following loss of sympathetic input. Following removal of the superior cervical...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.01.099
更新日期：2007-05-04 00:00:00
abstract：:The present study was carried out in order to determine whether angiotensin II (ANG II) exerts its stimulatory effect on plasma concentration of arginine vasopressin (AVP) and adrenocorticotrophic hormone (ACTH) by interacting with a (gamma-aminobutyric acid) GABAergic pathway. For this purpose, the effect of the GABA...
journal_title：Brain research
pub_type： 临床试验,杂志文章
doi：10.1016/0006-8993(89)90100-5
更新日期：1989-07-03 00:00:00
abstract：:Beta-amyloid(1-42) peptide (betaAP) was injected into the right nucleus basalis magnocellularis (nbm) of rats. After a 14-day survival time, the acetylcholinesterase and choline acetyltransferase activities and the number of muscarinic receptors were found biochemically to be significantly reduced in the ipsilateral f...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00823-9
更新日期：1995-10-09 00:00:00
abstract：:Injury to the central or peripheral nervous systems leads to the loss of cognitive and/or sensorimotor capabilities that still lack an effective treatment. Although injury to the nervous system involves multiple and complex molecular factors, alteration to protein homeostasis is emerging as a relevant pathological mec...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2016.04.053
更新日期：2016-10-01 00:00:00
abstract：:Kallikrein hydrolyzes various biologically active peptides, other than kininogens, such as vasoactive intestinal polypeptide (VIP), in vitro. Since kallikrein and VIP have been immunohistochemically shown to be present in the perivascular areas of the pineal gland, this study was designed to determine their topographi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00174-7
更新日期：1998-06-29 00:00:00
abstract：:Nerve cell dissociated from the cerebral cortex of mice were co-cultured with isolated pancreatic islets of Langerhans. After two weeks of co-culture, numerous axons had invaded the islets and differentiated nerve endings were closely juxtaposed to the endocrine islet cells. In contrast, no remnants of nerve cells wer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(81)90115-2
更新日期：1981-04-01 00:00:00
abstract：:The effect of high concentrations of L-ascorbic acid on the in vivo and in vitro growth of human neuroblastoma has been investigated. Directly implemented into cell culture it decreased the DNA, RNA and protein synthesis, and mitosis of neuroblastoma cells, without affecting normal neuronal cells. In vivo treatment of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91139-4
更新日期：1985-09-09 00:00:00
abstract：:Abnormally hyperphosphorylated tau is the major protein component of neurofibrillary tangles, the characteristic lesion of Alzheimer's disease (AD). Protein phosphatases (PP) type 1 (PP-1), type 2A (PP-2A) and type 2B (PP-2B) appear to be involved in the regulation of tau phosphorylation. The incidence of neurofibrill...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00904-3
更新日期：1996-11-25 00:00:00
abstract：:These experiments were conducted in order to better understand the role of catecholaminergic neurons in intracranial self-stimulation behaviour (ICSS) elicited from the lateral hypothalamus (LH). Two strains of mice which differ in their ICSS rate and their thresholds were studied. In a first time, we compared the cat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90341-4
更新日期：1983-04-18 00:00:00
abstract：:When N-methyl-D,L-aspartic acid was injected into the A5 catecholamine cell group of the rat, a dose-dependent decrease in blood pressure and heart rate was obtained. These cardiovascular changes were subsequently blocked by the (-) and (+) isomers of the aspartate receptor blocker 2-amino-5-phosphonovalerate (2-amino...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90076-2
更新日期：1982-10-14 00:00:00
abstract：:The role of central delta-opioid receptors in the mediation of opioid reinforcement and endogenous reward processes was examined using a non-biased place-preference conditioning procedure. Intracerebroventricular (i.c.v.) administration of the selective delta-receptor agonist, [D-Pen2, D-Pen5]-enkephalin (DPDPE, 10.0-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91667-2
更新日期：1987-12-15 00:00:00
abstract：:Oxytocin properties have been studied in different experimental models in order to obtain evidence for its analgesic properties. The analgesic effect of an oxytocinergic pathway descending from the hypothalamus reaching the dorsal horn of the spinal cord has been studied. In anesthetized rats, we recorded single units...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.01.050
更新日期：2006-04-07 00:00:00
abstract：:The present study focuses on the myelination of rat septohippocampal fibres that are known to originate from GABAergic parvalbumin-containing, fast-firing, fast-conducting neurons and from cholinergic slow-firing, slow-conducting neurons. With the combined immunofluorescence for parvalbumin/myelin basic protein and ch...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02653-6
更新日期：2000-09-29 00:00:00
abstract：:Individuals are found to have better recall for self-referent information than other types of information. However, attribution research has shown that self-reference is highly correlated with emotional valence. The present study attempted to identify and separate the processing of self-reference and emotional valence...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.03.049
更新日期：2007-06-04 00:00:00
abstract：:The contribution of the pedunculopontine nucleus to exploratory locomotion was investigated in rats. Locomotor activity recorded in a standard open-field apparatus was increased more than two-fold when wooden panels were inserted. This novelty-elicited locomotion was reduced significantly when procaine was injected bi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90584-2
更新日期：1989-04-24 00:00:00
abstract：:Endogenous gamma-aminobutyric acid (GABA) release from the rat medial preoptic area (MPOA) was measured in an in vitro slice technique with sensitive HPLC analysis. Oestrogen is demonstrated to increase GABA activity in the ovariectomised, oestrogen-primed (OVX-EB) rat prior to the luteinising hormone (LH) surge compa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91295-x
更新日期：1989-05-01 00:00:00
abstract：:A role for altered iron metabolism in the pathogenesis of Alzheimer's disease has been suggested by several reports associating the cardinal neuropathologic lesions with markers of free radical-induced damage and redox-active iron. We hypothesized that the abnormal distribution of iron in Alzheimer brain might result ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00002-x
更新日期：1998-03-30 00:00:00
abstract：:Trophic effects of neurturin, a member of the glial cell line-derived neurotrophic factor-family, have been demonstrated on mesencephalic dopaminergic neurons, suggesting its therapeutic potential for Parkinson's disease. This study was designed to test the neuroprotective and regenerative effects of an intrastriatal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02934-7
更新日期：2002-08-30 00:00:00
abstract：:Neurotrophins play a crucial role in the regulation of survival and the maintenance of specific functions for various populations of neurons. Neurotrophin-4 (NT-4) is most abundant in skeletal muscle, and is thought to promote sciatic nerve sprouting, inhibit agrin-induced acetylcholine receptor (AChR) clustering, evo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02288-0
更新日期：2001-07-13 00:00:00
abstract：:Prolonged electrical stimulation of the perforant pathway in the rat evokes epileptiform discharges in dentate granule cells and irreversibly damages hilar neurons. In this in vivo study, we demonstrate that similar perforant path stimulation in C57Bl/6 mice causes the same pattern of hippocampal neuron loss. Therefor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.02.055
更新日期：2006-04-26 00:00:00
abstract：:Transfer learning is an immanent feature of perceptual learning. Yet, despite the increasingly widespread application of transcranial direct current stimulation (tDCS) to study learning, transfer effects in response to tDCS have not been studied. Therefore, the present study investigated the transfer of tactile acuity...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.03.031
更新日期：2018-06-15 00:00:00
abstract：:Pouch young opossums aged from 5 to 34 days underwent unilateral eye enucleation and the projection from the remaining eye to the superior colliculus (SC) was explored at maturity by anatomical and physiological methods. The results were compared to data from normal or adult enucleated animals. Analysis of the experim...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90236-1
更新日期：1986-06-01 00:00:00
abstract：:Phenoxybenzamine can selectively eliminate the s-IPSP, in the presence of anti-cholinesterases that enhance s-IPSP and s-EPSP; and the alpha 2-antagonist, yohimbine, can partially but consistently depress s-IPSP selectively. The results provide positive pharmacological support for the monoaminergic nature of the trans...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90321-3
更新日期：1982-06-24 00:00:00
