Abstract：
:The patch-clamp technique was used to characterize the single channel ion currents in primary cultures of rat astrocytes. The most dominant channel type, which was found in over half of the inside-out membrane patches, was a potassium channel. The measured reversal potential was -67 mV, which is close to the calculated Nernst potential for potassium ions (-80 mV). These potassium channels activated with bursts of very brief openings. Once activated the channels did not inactivate. The measured probabilities of the channels to be closed showed at least 3 different modes of channel behaviour: one voltage-independent and two voltage-dependent modes. During each activity-mode a 'main' conductance level plus two other conductance levels were observed. In some recordings a pronounced outward rectification could also be seen.
journal_name
Brain Resjournal_title
Brain researchauthors
Jalonen T,Holopainen Idoi
10.1016/0006-8993(89)90360-0subject
Has Abstractpub_date
1989-04-10 00:00:00pages
177-83issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(89)90360-0journal_volume
484pub_type
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