Abstract：
:Extracellular field recordings were made in CA1 in the hippocampal explant cultures in oxygenated artificial cerebrospinal fluid. Schaffer collaterals were stimulated with 1-s trains of 60 Hz pulses every 10 min. Seizures were reliably elicited with progressive lengthening over 1-2 h. D-APV, an N-methyl-D-aspartate (NMDA) antagonist, stereoselectively blocked the development of seizures. Thus we have demonstrated that in vitro epileptogenesis occurs in hippocampal explant cultures through NMDA receptor mediated mechanisms.
journal_name
Brain Resjournal_title
Brain researchauthors
Shin C,Tamaki Y,Wilson JT,Butler L,Sakaguchi Tdoi
10.1016/0006-8993(92)91171-asubject
Has Abstractpub_date
1992-08-28 00:00:00pages
129-34issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(92)91171-Ajournal_volume
589pub_type
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