Abstract：
:The hippocampus is involved in key neuronal circuits that underlie cognition, memory, and anxiety, and it is increasingly recognized as a vulnerable structure that contributes to the pathogenesis of HIV-associated neurocognitive disorder (HAND). However, the mechanisms responsible for hippocampal dysfunction in neuroHIV remain unknown. The present study used HIV transgenic (Tg) rats and patch-clamp electrophysiological techniques to study the effects of the chronic low-level expression of HIV proteins on hippocampal CA1 pyramidal neurons. The dorsal and ventral areas of the hippocampus are involved in different neurocircuits and thus were evaluated separately. We found a significant decrease in the intrinsic excitability of CA1 neurons in the dorsal hippocampus in HIV Tg rats by comparing neuronal spiking induced by current step injections and by dynamic clamp to simulate neuronal spiking activity. The decrease in excitability in the dorsal hippocampus was accompanied by a higher rate of excitatory postsynaptic currents (EPSCs), whereas CA1 pyramidal neurons in the ventral hippocampus in HIV Tg rats had higher EPSC amplitudes. We also observed a reduction of hyperpolarization-activated nonspecific cationic current (Ih) in both the dorsal and ventral hippocampus. Neurotoxic HIV proteins have been shown to increase neuronal excitation. The lower excitability of CA1 pyramidal neurons that was observed herein may represent maladaptive homeostatic plasticity that seeks to stabilize baseline neuronal firing activity but may disrupt neural network function and contribute to HIV-associated neuropsychological disorders, such as HAND and depression.
journal_name
Brain Resjournal_title
Brain researchauthors
Sokolova IV,Szucs A,Sanna PPdoi
10.1016/j.brainres.2019.146431subject
Has Abstractpub_date
2019-12-01 00:00:00pages
146431eissn
0006-8993issn
1872-6240pii
S0006-8993(19)30485-8journal_volume
1724pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Following the administration of horseradish peroxidase (HRP) in the middle or lower cervical cord segments of neonatal (1-10 days), developing (15-20 days) and mature (2-4 months) albino rats, labeled pyramidal neurons were found in layer V of the cerebral cortex. They formed one continuous band of labeled neurons in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91327-6
更新日期：1983-04-11 00:00:00
abstract：:The convulsant compounds bicuculline (BICUC) and penicillin (PCN) are antagonists of GABA-mediated synaptic inhibition. In addition, we have shown that BICUC and PCN produced membrane depolarization of mouse spinal cord neurons in primary dissociated cell culture by blocking a potassium conductance, a non-synaptic dir...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90609-6
更新日期：1982-01-28 00:00:00
abstract：:Cytochrome P45011B1 (11 beta-hydroxylase) was detected in the brain of male rats by in situ hybridization methods. Normal Sprague-Dawley rats were compared to the transgenic strain TGR(mRen2)27, characterized by the expression of the murine Ren-2d renin gene and the development of severe hypertension. Specific ribopro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00540-9
更新日期：1996-09-09 00:00:00
abstract：:Practical utilization of in vivo electrochemistry for brain studies has been impeded by difficulties with specificity and quantitative measurements. Studies in brain slices combined with similar data from intact animals have provided important new information on the nature of the electrochemical studies. Using the enz...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90901-0
更新日期：1983-10-24 00:00:00
abstract：:We examined the brain uptake of prostaglandin D2 after its i.v. administration to mice. The determination of this prostaglandin in tissues was performed by a sensitive and rapid radioimmunoassay after purification of the prostaglandin by high-performance liquid chromatography. When 1.0 mg/kg of prostaglandin D2 was in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91079-6
更新日期：1986-10-22 00:00:00
abstract：:This study investigates the effects of levetiracetam (LEV) on the functional and structural properties of blood-brain barrier (BBB) in pentylenetetrazole (PTZ)-kindled rats with cortical dysplasia (CD). Pregnant rats were exposed to 145 cGy of gamma-irradiation on embryonic day 17. In offsprings, kindling was induced ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.05.033
更新日期：2009-07-24 00:00:00
abstract：:Axotomy produced an increase in the spike width and a decrease in amplitude of the afterhyperpolarization which followed the action potential in C-cells of bullfrog sympathetic ganglia. Although no change in B-cell conduction velocity was noted, C-cell conduction velocity increased significantly and approached that of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(87)80044-6
更新日期：1987-04-28 00:00:00
abstract：:We used double-barreled pH-sensitive microelectrodes to study the mechanisms by which the intracellular pH is regulated in the connective glial cells of the medicinal leech. The experiments indicate that a Cl(-)- and HCO3(-)-dependent mechanism mediates some recovery from intracellular alkalosis even in the absence of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91144-4
更新日期：1994-11-28 00:00:00
abstract：:In the present study we investigated whether nitroflurbiprofen (NFP) or nitro-aspirin can reduce the inflammatory response induced by continuous infusion of lipopolysaccharide (LPS) into the fourth ventricular space of the rat's brain for 30 days. The chronic LPS infusion produced an extensive inflammation that was pa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01081-6
更新日期：1999-01-02 00:00:00
abstract：:Met-enkephalin-like immunoreactive material (ME-LI) in the neurointermediate lobe of rat pituitary was dramatically altered by the long-term administration of drugs altering dopamine receptor activity. Treatment with the dopamine receptor antagonist haloperidol resulted in significant increases of ME-LI and treatment ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90586-4
更新日期：1985-05-13 00:00:00
abstract：:Partial, unilateral olfactory nerve section was performed in mice, and the behavior of the olfactory marker protein (OMP) studied, after this experimental manipulation, with the peroxidase--antiperoxidase method. The protein, which in normal mice is present only in mature olfactory sensory neurons, after unilateral le...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90162-1
更新日期：1981-03-30 00:00:00
abstract：:An in vitro method was developed to separately visualize dopaminergic, noradrenergic and serotoninergic terminals in the cerebral, hippocampal and cerebellar cortices of the rat, by means of the glyoxylic histochemical fluorescence method. Animals were pretreated with alpha-methylparatyrosine to deplete catecholamine ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90770-9
更新日期：1978-05-19 00:00:00
abstract：:Following the implantation of cobalt-gelatine pellets into the frontal cortex, epileptiform spikes in both primary and secondary foci developed and reached a peak between 7-12 days post implantation. Histological examination showed a necrotic lesion with terminal and fibre degeneration in brain areas connected with th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90288-7
更新日期：1975-07-25 00:00:00
abstract：:The cisternal spinal fluid (CF), plasma, and brain stem concentrations of 6 amino acids were measured in suckling rats between birth and one months of age. Each of the amino acids studied had its distinctive maturational pattern of CF concentration. Presumably these amino acids have separate mechanisms of transport fr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90098-1
更新日期：1977-01-01 00:00:00
abstract：:A study was made of the effects of electrochemically stimulating (ECS) and destroying the midbrain dorsal and median raphe nuclei on the estrogen-progesterone- (EP) induced surge of pituitary LH release in ovariectomized rats. ECS and lesions were produced simultaneously with anodal direct current through a chronicall...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90006-8
更新日期：1981-08-03 00:00:00
abstract：:Visual pathways (optic disc, optic nerve and pretectal regions) were electrically stimulated and evoked potentials were explored throughout the inferior olive in the anesthetized rat. Responsive areas were identified as the caudal half of the dorsal cap, nucleus beta and the most caudal region of subnucleus c of the m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91060-7
更新日期：1986-03-12 00:00:00
abstract：BACKGROUND:Previous experimental work using in situ zymography has shown very early increased plasminogen activation in ischemic regions after 3 h of ischemia with and without reperfusion. The objective of the present study was to evaluate the time course and extent of plasminogen activation in long-term permanent foca...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02769-4
更新日期：2000-11-03 00:00:00
abstract：:Antibodies to dopamine beta-hydroxylase (anti-D beta H) were taken up by noradrenergic nerve terminals in the iris following attachment to D beta H, and were transported back to, and accumulated in, the superior cervical ganglion (SCG). Concurrent, or prior destruction of noradrenergic terminals with 6-hydroxydopamine...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91097-7
更新日期：1984-06-03 00:00:00
abstract：:Using a combination of in situ hybridization and immunohistochemistry, the development of somatostatin (SS)-containing neurons and fibers was examined in the rat dorsal hippocampus and dentate gyrus. The major development of this hippocampal peptidergic system occurs postnatally. At postnatal day 1 (P1), neurons conta...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90013-2
更新日期：1988-05-01 00:00:00
abstract：:The retinohypothalamic tract, a monosynaptic retinal projection to the suprachiasmatic nucleus (SCN), is the path by which light entrains the circadian system to the external photoperiod. Serotonergic neurons in the mesencephalic median raphe nucleus (MnR) also give rise to a major SCN afferent projection. The present...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.02.083
更新日期：2005-05-17 00:00:00
abstract：:Distribution of prolactin-releasing peptide-like immunoreactivity (PrRP-LI) was investigated in the rat medulla with the use of a rabbit polyclonal antiserum against the human PrRP-31 peptide. PrRP-positive neurons were noted mainly in two areas of the caudal medulla: ventrolateral reticular formation and commissural ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01153-1
更新日期：1999-03-20 00:00:00
abstract：:Kindling is an experimental model for epilepsy in which repeated stimuli induce longer electrographic seizures and eventually cause behavioral convulsions. Although kindling has some features that are similar to chronic human epilepsy, it is not known whether this process plays a role in the development of chronic sei...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91071-y
更新日期：1993-10-22 00:00:00
abstract：:This study deals with the synaptology, morphologically identified postsynaptic targets, and origin of somatostatin (SOM) fibers in the rat lateral septal area (LSA) with special reference to those forming pericellular baskets. Septal vibratome sections were immunostained for SOM-14 in 3 experimental groups: control an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91743-k
更新日期：1991-11-22 00:00:00
abstract：:In acute cats deeply anesthetized with Nembutal, monosynaptic excitatory postsynaptic potentials (EPSPs) triggered by stimulation of the ventrolateral (VL) thalamic nucleus and the pes pedunculus were recorded in large pyramidal tract cells (PT cells). Deep anesthesia, low intensities of stimulation and an averaging t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90598-5
更新日期：1979-01-05 00:00:00
abstract：:Serotoninergic transmission is implicated in the photic and non-photic regulation of circadian rhythms. 5-HT (1-100 microM), carboxamidotryptamine (5-CT 0.1-10 microM) and (+)-8-hydroxy-dipropylaminotetraline (8-OH-DPAT, 1-30 microM) dose-dependently activated an outward current (5-100 pA) in 30% of neurons voltage-cl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02294-0
更新日期：2000-06-02 00:00:00
abstract：:Double-pulse stimulation of the perforant path input to the dentate gyrus was used in the following experiments to produce paired pulse depression in that site. This effect provided an estimate of GABA-mediated recurrent inhibition. The depression was enhanced by drugs that facilitate or mimic GABA action and attenuat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90909-5
更新日期：1983-10-24 00:00:00
abstract：:A motor disorder similar to idiopathic Parkinson's Disease develops in rhesus monkeys after several daily repeated doses of N-methyl-4-phenyl, 1,2,3,6-tetrahydropyridine (MPTP). The concentrations of peptides derived from proenkephalin A, proenkephalin B, substance P and somatostatin were measured by specific radioimm...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90133-1
更新日期：1984-11-26 00:00:00
abstract：:Using a double-labeling method that combines retrograde tracing and immunocytochemistry, we demonstrated the presence of a hippocampofugal gamma-aminobutyric acid (GABA)-like immunoreactive (GABA-LI) neuron system in the rat. As a preliminary experiment, knife-cut of the dorsal fornix was made and it resulted in a rem...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90757-8
更新日期：1987-04-14 00:00:00
abstract：:Variables influencing decision-making in real settings, as in the case of voting decisions, are uncontrollable and in many times even unknown to the experimenter. In this case, the experimenter has to study the intention to decide (vote) as close as possible in time to the moment of the real decision (election day). H...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.06.046
更新日期：2010-09-10 00:00:00
abstract：:Experiments were carried out on hippocampal slices from rats pretreated with a unilateral intraventricular injection of kainic acid. The kainic acid produced a lesion of the CA3 area in the hippocampus ipsilateral to the site of injection. The resulting neuroanatomically modified hippocampal slices allowed the indepen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90570-x
更新日期：1983-08-08 00:00:00
