Abstract：
:The convulsant compounds bicuculline (BICUC) and penicillin (PCN) are antagonists of GABA-mediated synaptic inhibition. In addition, we have shown that BICUC and PCN produced membrane depolarization of mouse spinal cord neurons in primary dissociated cell culture by blocking a potassium conductance, a non-synaptic direct effect. Both compounds also prolonged calcium-dependent action potentials of mouse dorsal root ganglion and spinal cord neurons in cell culture. Thus, BICUC and PCN had both synaptic and non-synaptic actions. The possibility that both synaptic and non-synaptic actions of BICUC and PCN are involved in their convulsant mechanism of action is discussed.
journal_name
Brain Resjournal_title
Brain researchauthors
Heyer EJ,Nowak LM,Macdonald RLdoi
10.1016/0006-8993(82)90609-6subject
Has Abstractpub_date
1982-01-28 00:00:00pages
41-56issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(82)90609-6journal_volume
232pub_type
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