Abstract：
:In this study we examined the induction of heme oxygenase-1 (HO-1) in glia in the traumatized rat brain. HO-1 was immunolocalized in fixed sections of brain 3 h to 5 days after injury. Induction of this enzyme in astrocytes, microglia/macrophages, and oligodendrocytes was evaluated using immunofluorescent double labeling with monoclonal antibodies to glial fibrillary acidic protein, complement C3bi receptor, and myelin basic protein. Induction of HO-1 was apparent in the injured hemisphere and cerebellum as early as 24 h postinjury. The protein was likewise noted in similar regions of the brain at 72 h postinjury but appeared to be more widespread in its distribution. At 5 days postinjury, there was a notable decline in the degree of immunostaining for HO-1. HO-1 was typically induced in astrocytes in the cerebral cortex at the site of impact, in the deep cortical layers adjacent to the hemorrhagic lesions, and in the hippocampus. HO-1 was induced in Bergmann glia in the vermis of cerebellum. In addition, HO-1 was also induced in microglia/macrophages scattered throughout the ipsilateral cerebral cortex, cerebellum and subarachnoid space. These findings demonstrate prolonged glial induction of HO-1 in the traumatized brain. Such a response may reflect a protective role of these cells against secondary insults including oxidative stress.
journal_name
Brain Resjournal_title
Brain researchauthors
Fukuda K,Richmon JD,Sato M,Sharp FR,Panter SS,Noble LJdoi
10.1016/0006-8993(96)00680-4subject
Has Abstractpub_date
1996-10-14 00:00:00pages
68-75issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(96)00680-4journal_volume
736pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Amyloid deposition, a histopathological feature of Alzheimer's disease brain, may be the underlying cause of this disease. The isolation of enzymes involved in both the normal and aberrant or alternative processing of the beta-amyloid precursor protein may lead to an understanding of how beta-protein, the major compon...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91279-n
更新日期：1992-09-04 00:00:00
abstract：:We have applied a technique involving multi-channel linear filtering to the problem of sorting and identifying singly unit neuronal activity in records containing several simultaneously active units. The technique is effective even when the waveforms of two or more nerve impulses are superimposed. We have applied it s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90883-5
更新日期：1975-08-22 00:00:00
abstract：:Cholecystokinin-octapeptide-like-immunoreactivity (CCK-8-LI) is demonstrable by the indirect immunofluorescent technique in cerebral cortical neurons cultured from fetal rats. Prominent and widespread staining is seen in widely ramifying cellular processes throughout the cultures. Staining in neuronal cell bodies is e...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91456-2
更新日期：1984-02-13 00:00:00
abstract：:Basic FGF has recently been shown to produce systemic and cerebral vasodilation. To test the hypothesis that bFGF increases regional cortical blood flow (rCBF), rCBF and brain pHi were measured while bFGF or vehicle was superperfused onto the cortex of rabbits. The results of this study demonstrate that topical applic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91167-3
更新日期：1994-11-28 00:00:00
abstract：:Melatonin is a hormone that mostly produced from the pineal gland, and it performs as a strong neuroprotectant to both neuron and glial cells against methamphetamine (METH)-induced neurotoxicity. Recently, it has been found that METH also damages the blood brain barrier (BBB) structure and function. However, the prote...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.08.045
更新日期：2016-11-01 00:00:00
abstract：:Recently, missense mutations in the gene TARDBP encoding TDP-43 have been linked to familial ALS. The discovery of genes encoding these RNA binding proteins, such as TDP-43 and FUS/TLS, raised the notion that altered RNA metabolism is a major factor underlying the pathogenesis of ALS. To begin to unravel how mutations...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2012.04.031
更新日期：2012-06-26 00:00:00
abstract：:The effects of acute opiate receptor stimulation on regional cerebral oxygen consumption and blood flow were examined in 9 regions of the artificially respired, alpha-chloralose-anesthetized cat. Regional cerebral arterial and venous oxygen saturation were examined microspectrophotometrically and regional cerebral blo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91262-9
更新日期：1984-01-23 00:00:00
abstract：:We investigated the responses of putative aortic baroreceptor neurons to mechanical stimulation of their processes. Putative aortic baroreceptor neurons were identified by applying the carbocyanine dye DiI to the adventitia of the aortic arch of anesthetized rats. After at least 1 week, the nodose ganglia were removed...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00153-4
更新日期：1997-05-16 00:00:00
abstract：:Tyrosine hydroxylase phenotype expression was investigated in the catecholaminergic population of the locus coeruleus neurons of two pure inbred mouse strains, Balb/C and C57Black/6. Therefore, we have characterized the precise organization of tyrosine hydroxylase-expressing perikarya population, in control animals an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00074-1
更新日期：1996-05-20 00:00:00
abstract：:The patterns of expression of the Bcl-2, Bax, and Bcl-xL proteins were examined immunocytochemically in rat hippocampus and neocortex after severe hypobaric hypoxia (180 Torr for 3 h) and severe hypoxia preconditioned by intermittent mild hypoxia (360 Torr for 2 h daily, for 3 consecutive days, 24 h prior to severe hy...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.053
更新日期：2006-05-17 00:00:00
abstract：:Death receptors are associated with the homeostatic and pathologic induction of cell death. TR3 is a recently characterised member of the death receptor family that is expressed in the adult brain. In order to establish the role of TR3 in acute CNS disease and chronic neurodegeneration, we analysed brain regions from ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02417-8
更新日期：2000-02-28 00:00:00
abstract：:We have monitored the expression of c-fos protein in the medulla oblongata of the ferret, using immunocytochemistry, to identify the brainstem pathways involved in the mediation of nausea and vomiting caused by the antineoplastic drug cisplatin. Cisplatin administration resulted in c-fos-like immunoreactivity (FLI) in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91654-j
更新日期：1991-11-29 00:00:00
abstract：:The density of protein gene product 9.5- and tyrosine hydroxylase-immunoreactive nerve fibers innervating circumvallate papillae of the tongue was substantially increased in transgenic mice that overexpressed nerve growth factor (NGF) when compared with age-matched controls. The fiber density was age-dependent. Only t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01336-9
更新日期：1996-01-29 00:00:00
abstract：:The nonsteroidal anti-inflammatory drugs are presumed to produce their analgesic effects by inhibiting the cyclooxygenase catalyzed metabolism of arachidonic acid to hyperalgesic prostanoids. This study examined the hyperalgesic effect of a range of prostaglandins. We found, employing the rat paw-withdrawal test, that...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90389-s
更新日期：1990-12-24 00:00:00
abstract：:Ethylcholine aziridinium ion (AF64A) diluted in artificial perilymph, or artificial perilymph alone was infused into the cochlea of chinchillas. After a survival time of 7 days, the cochleas were fixed with aldehydes, post-fixed in osmium and embedded in epoxy resin for light and electron microscopy. The ultrastructur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90889-4
更新日期：1991-03-22 00:00:00
abstract：:Intracellular transport of newly synthesized proteins through organelles in the perikarya of regenerating goldfish retinal ganglion cells was studied using electron microscopic autoradiography. Retinas were removed 14 or 30 days after optic tract cut or sham operation, pulse-labeled in [3H]proline-containing medium fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90832-0
更新日期：1982-05-06 00:00:00
abstract：:Little is known about the cells or mechanisms of O2 chemoreception in vertebrates other than mammals. The purpose of this study, therefore, was to identify O2-sensitive chemoreceptors in a fish. Putative O2-sensitive chemoreceptors were dissociated from the gills of channel catfish, Ictalurus punctatus, and cultured. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.085
更新日期：2006-05-30 00:00:00
abstract：:We investigated the localization of components of translational machinery and their regulators in the postsynaptic region. We examined several components, especially those involved in translational regulation: components of (1) MAPK-Mnk-eIF4E, (2) PI3-kinase-PDK-Akt/PKB-FRAP/mTOR-PHAS/4EBP, (3) p70S6K-S6 ribosomal pro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02523-x
更新日期：2003-05-16 00:00:00
abstract：:The purpose of this study was to investigate morphological characteristics of the synaptic relations of choline acetyltransferase (ChAT)-positive terminals that are made with a variety of post-synaptic profiles in the lateralis medialis-suprageniculate nuclear complex (LM-Sg) using ChAT, gamma-aminobutyric acid (GABA)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01208-5
更新日期：1997-01-30 00:00:00
abstract：:Extracellular recordings were conducted in the paraflocculus of anesthetized Long-Evans pigmented rats to determine how ionotophoresis of norepinephrine (NE) affects the responsiveness of individual Purkinje cells and interneurons to presentations of visual stimuli within their visual receptive fields. Presentations o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91421-c
更新日期：1990-04-30 00:00:00
abstract：:Alterations in neurotrophic signaling pathways may contribute to the changes in the mesolimbic dopamine system induced by chronic morphine exposure. In a rat model of morphine dependence, we previously identified increased levels of phospholipase C gamma-1 (PLCgamma1) immunoreactivity specifically within the ventral t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.04.059
更新日期：2007-07-02 00:00:00
abstract：:Recent research has shown that familiarity contributes to associative memory when the to-be-associated stimuli are unitized during encoding. However, the specific processes underlying familiarity-based recognition of unitized representations are still indefinite. In this study, we present electrophysiologically dissoc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.08.089
更新日期：2010-11-11 00:00:00
abstract：:There is a large body of evidence indicating important interactions between the adenosine and opioid systems in regulating pain at both the spinal and supraspinal level. Mice lacking the mu-opioid receptor (MOR) gene have been successfully developed and the animals show complete loss of analgesic responses to morphine...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02536-2
更新日期：2002-07-05 00:00:00
abstract：:From previous inverse dynamic analyses of human leg extensions, it was hypothesized that the underlying processes for the activation of mono- and biarticular muscles are different; the mono-articular muscles being activated when they shortened, whereas the biarticular muscles appeared responsible for the control of th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01327-3
更新日期：1997-03-21 00:00:00
abstract：:17β-estradiol (E2 or estrogen) is an endogenous steroid hormone that is well known to exert neuroprotection. Along these lines, one mechanism through which E2 protects the hippocampus from cerebral ischemia is by preventing the post-ischemic elevation of Dkk1, a neurodegenerative factor that serves as an antagonist of...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2012.12.015
更新日期：2013-06-13 00:00:00
abstract：:The present study examined the effects of excitotoxins which activate distinct excitatory amino acid (EAA) receptor subtypes on the levels of Methionine-enkephalin-like immunoreactivity (ME-i.r.) in the striatum and globus pallidus, with a view to developing a model of the striatopallidal enkephalin deficit that preva...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90029-b
更新日期：1990-12-17 00:00:00
abstract：:This study examined the involvement of N-methyl-D-aspartate receptors (NMDARs) in experience-dependent synaptic plasticity. Rats chronically received an NMDA receptor antagonist (AP5) or saline (SAL) and were exposed to individual cages (IC) or environmental enrichment (EC). AP5 impaired measures of hippocampal-depend...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02379-9
更新日期：2000-07-14 00:00:00
abstract：:Multiple sclerosis patients typically experience increased pain that is relatively insensitive to opiate treatment. The mechanistic basis for this increased nociception is currently poorly understood. In the present study, we utilized the Theiler's murine encephalomyelitis virus (TMEV) model of MS to examine possible ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.11.034
更新日期：2008-01-29 00:00:00
abstract：:Although there are indications of growth in the size and myelination of the rat corpus callosum during adulthood, it is not known how long this growth continues. In addition, the potential for age-related changes in these measures to affect the sex differences seen in adulthood has not been examined. Here the size of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.01.043
更新日期：2007-04-20 00:00:00
abstract：:The purpose of the current study is to investigate the functional connections between the central histaminergic and cholinergic systems at NTS level in hypotensive condition. Experiments were carried out in male Wistar Albino rats. The hypotension was achieved by withdrawing a total volume of 1.5ml blood/100g bodyweig...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.06.047
更新日期：2016-10-15 00:00:00
