Abstract：
:Death receptors are associated with the homeostatic and pathologic induction of cell death. TR3 is a recently characterised member of the death receptor family that is expressed in the adult brain. In order to establish the role of TR3 in acute CNS disease and chronic neurodegeneration, we analysed brain regions from Alzheimer's disease (AD), stroke and neurotrauma patients, using a novel anti-peptide antibody generated to an exposed epitope in the extracellular domain of the receptor. We show a statistically significant increase in TR3 protein levels in AD brain samples but not in stroke, neurotrauma or control samples. The increase observed for TR3 was specific to neurons in regions associated with AD pathology. This is the first report describing the neuron-specific regulation of a death receptor in chronic disease and may indicate that a TR3 receptor-mediated signalling pathway is involved in AD-associated neuronal loss.
journal_name
Brain Resjournal_title
Brain researchauthors
Newman SJ,Bond B,Crook B,Darker J,Edge C,Maycox PRdoi
10.1016/s0006-8993(99)02417-8subject
Has Abstractpub_date
2000-02-28 00:00:00pages
131-40issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(99)02417-8journal_volume
857pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The adrenergic transmitter norepinephrine (NE) dramatically increases the prominence of only two out of the hundreds of [35S]methionine-labeled pineal proteins resolved by two-dimensional polyacrylamide gel electrophoresis (2D-PAGE). One of these regulated proteins is AIP 37/6 (37 kDa, pI approximately 6). The labelin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01412-8
更新日期：1996-03-25 00:00:00
abstract：:Mild NMDA receptor activation is correlated with neuroprotection in models of cerebral ischemia. Neuroprotection with NMDA manifests as a form of ischemic tolerance and involves the induction of cellular stress systems sensitive to disturbances in cellular calcium homeostasis. Unilateral micro-injection of 10, 160 and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.10.014
更新日期：2009-01-09 00:00:00
abstract：:In this study, the effects of chronic morphine administration (20-30 days) on long-term potentiation (LTP) were investigated at the Schaffer collateral-CA1 pyramidal cell synapses of the rat hippocampal slices. Orthodromic population spike (OPS) amplitude and delay (peak latency) were measured as indices of increase i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01148-2
更新日期：1999-01-09 00:00:00
abstract：:We hypothesized that abnormal activity and adrenergic sensitivity in injured dorsal root ganglion (DRG) neurons are due to an intrinsic alteration of the cell body membrane. We investigated the effects of adrenergic stimulus on the activities of Ca2+ and K+ channels of DRG neurons in a rat chronic constriction injury ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01499-7
更新日期：1999-06-19 00:00:00
abstract：:The inhibitory potency of ethanol upon excitatory amino acid induced depolarizations of rat hippocampal CA1 pyramidal cells was assessed in the presence and absence of magnesium (Mg2+) using the grease-gap technique. Ethanol shifted the N-methyl-D-aspartate (NMDA) dose-response curves to the right in a non-parallel ma...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91486-k
更新日期：1991-04-19 00:00:00
abstract：:The immediate-early gene egr-1 has been shown to have an increased expression during long-term potentiation (LTP). High frequency electrical stimulation induces an increase in such expression in the dorsal horn of the spinal cord. However, evidence demonstrating the activation of this gene in the spinal cord and its r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.05.041
更新日期：2010-07-23 00:00:00
abstract：:The patterns of preganglionic projections in the avian sympathetic system are highly specific. Preganglionic axons arising from the T1 spinal segment, for example, project predominantly in the rostral direction, whereas T4 preganglionic axons project predominantly in the caudal direction. Moreover, each ganglion recei...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90149-0
更新日期：1987-03-01 00:00:00
abstract：:The chemokines CCL2 and CCL7 are upregulated in the brain during several neurodegenerative and acute diseases associated with infiltration of peripheral leukocytes. Astrocytes can respond to inflammatory cytokines like IL-1beta and TNF-alpha by producing chemokines. This study aims to test the ability of IL-1beta and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.06.081
更新日期：2009-09-01 00:00:00
abstract：:In larval lamprey 4 weeks after a spinal transection locomotor patterns were usually complete along the body in whole animals. In in vitro preparations locomotor activity was restricted to a few millimeters below the transection. Retrograde labeling indicated that descending axons from a few brainstem neurons had grow...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90252-i
更新日期：1993-01-29 00:00:00
abstract：:p-Chlorophenylalanine was administered to rats to inhibit hepatic phenylalanine hydroxylase activity. Two days later, phenylalanine injection was noted to produce substantial increases in serum phenylalanine levels, and relatively modest increments in serum tyrosine levels. Rats injected with p-chlorophenylalanine 2 d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90777-4
更新日期：1989-10-16 00:00:00
abstract：:We previously described a rat model where the injection of formalin in the tail induced a facilitation of the hindpaw withdrawal reflexes (hyperalgesia). In the present work, after injecting formalin in the tail, we measured the levels of pro-nociceptive mediators tumor necrosis factor-alpha (TNF) and substance P (SP)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.06.007
更新日期：2004-09-03 00:00:00
abstract：:To characterize optical responses (ORs) evoked by white matter (WM) stimulation in slices of rat visual cortex (VC) stained with voltage sensitive dyes, time course of ORs in each layer was investigated by recording ORs with a linearly aligned photodiode array, and the spatial patterns of the ORs at specified time aft...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00767-6
更新日期：1996-10-28 00:00:00
abstract：PURPOSE:Diffusion kurtosis imaging (DKI) is a MRI technique which can measure alterations in the diffusion of water molecules to reflect tissue changes in both white and grey matter. This study evaluated the potential of DKI for the early diagnosis of radiation-induced temporal lobe changes in the grey and white matter...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.07.041
更新日期：2016-10-01 00:00:00
abstract：:Inhibitory GABAergic synaptic transmission in the mammalian hippocampus depends upon a hyperpolarized reversal potential for Cl(-) (ECl). To examine the regulation of ECl hyperpolarization we cultured hippocampal neurons for two weeks in either a low- or a high-concentration of KCl (2.6 or 18.7 mM, respectively). Neur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.02.038
更新日期：2008-04-18 00:00:00
abstract：:The binding of the adenosine receptor agonists, [3H]N-ethylcarboxamidoadenosine (NECA) and [3H]cyclohexyladenosine (CHA) to membrane preparations and to cryostat sections of the rat brain was examined. The xanthine derivative, 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) was ca. 500-fold more effective at A1 than at A2 ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90589-5
更新日期：1986-03-19 00:00:00
abstract：:The effects of axotomy, chemical sympathectomy and preganglionic denervation on the expression of the neuropeptides, pituitary adenylate cyclase-activating peptide (PACAP), galanin (GAL), and the PACAP type 1 receptor in the rat superior cervical ganglion (SCG) were investigated by immunocytochemistry, in situ hybridi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00923-2
更新日期：1997-11-14 00:00:00
abstract：:We have studied the effects of prenatal protein malnutrition on development of the hippocampal and frontal cortical electroencephalographic (EEG) activity. Using power spectral analyses in rats of several age groups we found that protein malnutrition, instituted prenatally and continued postnatally, produces marked al...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90172-5
更新日期：1985-10-01 00:00:00
abstract：:To investigate the reversibility of neuronal functions during deep and mild hypothermia, we have examined changes in membrane properties of pyramidal neurons of the CA3 region of hippocampal slices during cooling and rewarming (8 approximately 37 degrees C) of the perfusion medium. Hypothermia reduced the excitatory p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03285-6
更新日期：2001-03-02 00:00:00
abstract：:Opioid modulation of calcium currents was studied in acutely dissociated rat basal forebrain neurons using the whole cell patch-clamp recording technique. The mu-opioid receptor agonist DAGO reversibly suppressed high-voltage activated calcium currents and slowed their rate of activation, while neither delta- nor kapp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00206-0
更新日期：1997-05-30 00:00:00
abstract：:Sex differences in cocaine's mechanisms of action and behavioral effects have been widely reported. However, little is known about how sex influences intracellular signaling cascades involved with drug-environment associations. We investigated whether ERK/CREB intracellular responses in the mesocorticolimbic circuitry...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.04.060
更新日期：2013-07-03 00:00:00
abstract：:This neuroimaging study investigated the neural mechanisms of the effect of conversation on visual event detection during a driving-like scenario. The static load paradigm, established as predictive of visual reaction time in on-road driving, measured reaction times to visual events while subjects watched a real-world...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.10.002
更新日期：2009-01-28 00:00:00
abstract：:We have recently reported the existence within chick embryo heart cell conditioned medium (HCM) of two distinct and independently assayable factors. One agent, ciliary neuronotrophic factor (CNTF), supports the in vitro survival of 8-day chick embryo ciliary ganglionic (CG) neurons. The other factor, polyornithine-att...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90105-0
更新日期：1981-02-09 00:00:00
abstract：:Spontaneous and hypothalamically induced hippocampal rhythmical slow activity (RSA or theta) was studied acutely in rats anaesthetized with urethane or immobilized with D-tubocurarine. Systematic tracking of microelectrodes showed two foci of hippocampal RSA, one located in the basal part (stratum oriens) of CAl (mean...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90711-3
更新日期：1976-12-17 00:00:00
abstract：:Cerebral autoregulation was tested here in 3- and 18-month-old spontaneously hypertensive rats (SHR) and Wistar Kyoto controls (WKY). Cerebral blood flow (CBF) was measured in each rat using radioactive micropheres under unanesthetized control conditions and after hypotension induced by ganglionic blockade. Under cont...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90454-6
更新日期：1981-06-09 00:00:00
abstract：:Cigarette smoke passed through the nasal cavity of atenolol pre-treated anesthetized spontaneously breathing rabbits caused a bradycardia which was significantly modified by intracisternal application of the 5-HT1A receptor ligands 8-OH-DPAT (50 micrograms.kg-1) and buspirone (200 micrograms.kg-1). 8-OH-DPAT attenuate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91345-s
更新日期：1993-12-03 00:00:00
abstract：:Estrogens exert a wide variety of actions on reproductive and non-reproductive functions. These effects are mediated by slow and long lasting genomic as well as rapid and transient non-genomic mechanisms. Besides the host of studies demonstrating the role of genomic actions at the physiological and behavioral level, m...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2006.07.098
更新日期：2006-12-18 00:00:00
abstract：:In the present study, temporal changes of voltage-gated Ca(2+) channel (VGCC) immunoreactivities were evaluated in the gerbil hippocampus following ischemia. P/Q-type VGCC immunoreactivity was elevated in the hippocampus in the 3 h post-ischemic group. In the 30 min post-ischemic group, N-type VGCC immunoreactivity be...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02283-2
更新日期：2003-04-25 00:00:00
abstract：:The D stereoisomer of dihydroxyphenylalanine (D-DOPA) and its alpha-keto acid metabolite 3,4-dihydroxyphenylpyruvic acid (DHPPA) when infused into the striatum, significantly increased in vivo extracellular dopamine levels. Following D-DOPA administration, the cumulative increase in dopamine levels was 30% of the incr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00116-3
更新日期：1996-04-29 00:00:00
abstract：:Manipulations of either discrete emotions (e.g. happiness) or affective dimensions (e.g. positivity) have a long tradition in emotion research, but interactive effects have never been studied, based on the assumption that the two underlying theories are incompatible. Recent theorizing suggests, however, that the human...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.03.045
更新日期：2014-05-20 00:00:00
abstract：:Concentrations of monoamines and metabolites and uric acid were measured in sequential 15-min microdialysis samples taken from the area of the supraoptic nucleus (SON) in 9 urethane-anaesthetized rats. A decrease in blood pressure of 40 mm Hg was induced by withdrawing 3-4 ml of blood from an indwelling jugular cathet...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91016-5
更新日期：1988-02-09 00:00:00
